276 research outputs found
Taking refugees for a ride? : the politics of refugee return in Afghanistan
No full textDavid Turton and Peter MarsdenParallel als Buch-Ausg. erschiene
The establishment of a world heritage area
No full text[Extract] Tropical rainforest was often seen as a barrier to progress in northern Queensland and the descriptive terminology used most frequently reflected that (scrub, jungle; see Stork and Turton, Chapter 1, this volume). Clearing the scrub to develop agriculture was a principal task of the early European settlers (see Turton, Chapter 5, this volume), as was the continuing attempt to remove the timber resources. The notion that the rainforest might need protecting from the impacts of human activity was quite weird until very recent times. In a historical review of attitudes towards rainforest in northern Queensland, Valentine (1980) documented numerous antagonistic and utilitarian views from explorers, settlers and government agencies. Indigenous Australians appreciated the qualities of tropical rainforests, which were integral to their culture, economy and society. The wider community has also seen the development of a much more positive view about tropical rainforests over time. One of the first to advocate its protection was John Busst, a local Bingal Bay resident who is best known for his work to save the Great Barrier Reef. He also formed the Rainforest Protection Society in 1962 and was at that time thought somewhat quirky for these ideas. His perspicacity is now acknowledged
Taking refugees for a ride? : the politics of refugee return in Afghanistan / David Turton and Peter Marsden
No full textParallel als Buch-Ausg. erschiene
Mutations within the transcription factor PROP1 are rare in a cohort of patients with sporadic combined pituitary hormone deficiency (CPHD)
No full textThe definitive version is available at www.blackwell-synergy.comObjective Mutations within the pituitary-specific paired-like homeobox gene PROP1 have been described in 50–100% of patients with familial combined pituitary hormone deficiency (CPHD). We screened a cohort of sporadic (n = 189) and familial (n = 44) patients with hypopituitarism (153 CPHD and 80 isolated hormone deficiencies) for mutations within the coding sequence of PROP1. Design and patients Patients with congenital hypopituitarism were recruited from the London Centre for Paediatric Endocrinology as well as several national and international centres. The pituitary phenotype ranged from isolated growth hormone deficiency (IGHD) to panhypopituitarism. Clinical data, including endocrine and neuro-radiological studies were obtained from patient records, and DNA was collected and screened for mutations within PROP1 using PCR and single-stranded conformation polymorphism (SSCP) analysis. Positive results on SSCP were sequenced directly. Results The prevalence of PROP1 mutations in unselected sporadic cases of hypopituitarism was lower (1·1%) than in familial cases (29·5%). PROP1 mutations can be associated with a highly variable phenotype, and both pituitary hypoplasia and pituitary hyperplasia. We describe the waxing and waning of a pituitary mass over 20 months in association with a PROP1 mutation that is predicted to lead to complete loss of function. Additionally, we have identified a possible founder mutation in CPHD patients from the Indian subcontinent. Conclusions PROP1 mutations are rare in sporadic cases of CPHD, although the prevalence rises if there is a positive family history or if the patients are carefully selected with respect to the endocrine and neuroradiological phenotype. There is considerable phenotypic variability in families with the same mutation, indicating the role of other genetic or environmental factors on phenotypic expression. Finally, the pituitary enlargement that is observed in patients with PROP1 mutations can wax and wane in size before eventual involution.James P. G. Turton, Ameeta Mehta, Jamal Raza, Kathryn S. Woods, Tiulpakov, Anatoly,Joseph Cassar, Paul Q. Thomas, Marumudi Eunice, Ariachery C Ammini, Pierre M. Bouloux, Jerzy Starzyk, Peter C. Hindmarsh and Mehul T. Dattan
Muscle Wasting in Critical Care
No full text<p>SPSS files of the data collected from patients taking part in the muscle wasting in critical care study.</p>
Ode: to the judge
No full text1 sheet ([2] pages) : illustrations ; 34 x 18 cm. "A striking and forceful poem with an obvious reference to Lloyd Kenyon, first Baron Kenyon (1732-1802), Lord Chief Justice, in the satirical headline illustration. Kenyon was a forceful advocate against 'seditious libel', something of a 1790's phenomenon. The gist of the contents is to comment on the state of the law and its administrators and indeed the poem cites several cases: Tom Llyod—publishing a satiric squib held to be seditious in 1792; Reverend William Winterbotham—charged for seditious words uttered in two exquisitely written sermons in 1793."— John Turton Antiquarian Books. http://morris.law.yale.edu/record=b170080
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