332 research outputs found
Peter Singer and 'Lives Not Worth Living': Comments on a Flawed Argument From Analogy
No full textThe Australian bioethicist Peter Singer has presented an intriguing
argument for the opinion that it is quite proper (morally) to deem the lives
of certain individuals not worth living and so to kill them. The argument is
based on the alleged analogy between the ordinary clinical judgement that a
life with a broken leg is worse than a life with an intact leg (other things
being equal), and that the broken leg therefore ought to be mended, on the one
hand, and the judgement that the lives of some individuals, for example,
severely disabled infants, are not worth living and therefore ought to be
terminated, on the other. In the present article it is argued that Singer's
argument is flawed, intellectually and/or ethically
Straw Men with Broken Legs: A Response to Per Sundstrom
No full texthttp://dx.doi.org/10.1136/jme.21.2.8
explore, Spring 2016, Vol. 19: Our Future on a Shared Planet
No full textLaudato Si\u27 in Silicon Valley - Cardinal Peter Turkson Climate Resilience, Social Entrepreneurship, and Silicon Valley - Thane Kreiner Environmental Justice, Technology, and Silicon Valley - Kirk Hanson Public Policy and the Environmental Teachings of Pope Francis - Sam Liccardo Social Action and Community in an Integral Ecology - Poncho Guevara Securing the Well-bEing of People and Nature: A Reflection on Laudato Si\u27 - Gretchen Daily Valuing our Common Home - William Sundstrom Laudato Si\u27 and Inclusive Capitalism - John Denniston Leadership Ethics and Laudato Si\u27 - Ann Skeet Multifaith Dialogue on Climate Justice: Principles and Practices Across Traditions - Rev. Sally Bingham, Rabbi Allan Berkowitz, Linda Cutts, Ameena Jandali, Cardinal Peter Turkson 2015-2016 Bannan Institute Lecture Series Thriving Neighbors Initiative 2015-2016 Grant Reports 2016-2018 Bannan Institute: Is there a common good in our common home?https://scholarcommons.scu.edu/explore/1035/thumbnail.jp
Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells
No full textNew neurones are produced in the adult hippocampus throughout life and are necessary for certain types of hippocampal learning. Little, however, is known about the control of hippocampal neurogenesis. We used primary hippocampal cultures from early post-natal rats and neuropeptide Y Y1 receptor knockout mice as well as selective neuropeptide Y receptor antagonists and agonists to demonstrate that neuropeptide Y is proliferative for nestin-positive, sphere-forming hippocampal precursor cells and beta-tubulin-positive neuroblasts and that the neuroproliferative effect of neuropeptide Y is mediated via its Y1 receptor. Immunohistochemistry confirmed Y1 receptor staining on both nestin-positive cells and beta-tubulin-positive cells in culture and short pulse 5-bromo-2-deoxyuridine studies demonstrated that neuropeptide Y has a proliferative effect on both cell types. These studies suggest that the proliferation of hippocampal neuroblasts and precursor cells is increased by neuropeptide Y and, therefore, that hippocampal learning and memory may be modulated by neuropeptide Y-releasing interneurones
A well-conserved Plasmodium falciparum var gene shows an unusual stage-specific transcript pattern
No full textThe var multicopy gene family encodes Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variant antigens, which, through their ability to adhere to a variety of host receptors, are thought to be important virulence factors. The predominant expression of a single cytoadherent PfEMP1 type on an infected red blood cell, and the switching between different PfEMP1 types to evade host protective antibody responses, are processes thought to be controlled at the transcriptional level. Contradictory data have been published on the timing of var gene transcription. Reverse transcription-polymerase chain reaction (RT-PCR) data suggested that transcription of the predominant var gene occurs in the later (pigmented trophozoite) stages, whereas Northern blot data indicated such transcripts only in early (ring) stages. We investigated this discrepancy by Northern blot, with probes covering a diverse var gene repertoire. We confirm that almost all var transcript types were detected only in ring stages. However, one type, the well-conserved varCSA transcript, was present constitutively in different laboratory parasites and does not appear to undergo antigenic variation. Although varCSA has been shown to encode a chondroitin sulphate A (CSA)-binding PfEMP1, we find that the presence of full-length varCSA transcripts does not correlate with the CSA-binding phenotype
Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy
No full textNeurofibrillary tangles (NFTs) are associated with neuronal loss and correlate with cognitive impairment in Alzheimer disease, but how NFTs relate to neuronal death is not clear. We studied cell death in Tg4510 mice that reversibly express P301L mutant human tau and accumulate NFTs using in vivo multiphoton imaging of neurofibrillary pathology, propidium iodide (PI) incorporation into cells, caspase activation, and DNA labeling. We first observed that in live mice, a minority of neurons were labeled with the caspase probe or with PI fluorescence. These markers of cell stress were localized in the same cells and appeared specifically within NFT-bearing neurons. Contrary to expectations, the PI-stained neurons did not die during a day of observation; the presence of Hoechst-positive nuclei in them on the subsequent day indicated that the NFT-associated membrane disruption, as suggested by PI staining, and caspase activation do not lead to immediate death of neurons in this tauopathy model. This unique combination of in vivo multiphoton imaging with markers of cell death and pathological alteration is a powerful tool for investigating neuronal damage associated with neurofibrillary pathology
Palaces for the People: How the Historical Development of Organizational Culture in American Public Libraries Aids Librarians in Navigating Growing Politicization
No full textAs a cornerstone of American democracy, public libraries in the US play an essential role in facilitating the freedom of access to information and community engagement. However, since 2020, American public libraries have experienced a rise in politicized attacks by conservatives in an effort to radically alter library collections and programming through book challenges and protests. Against the backdrop of democratic backsliding, the politicization of public libraries becomes especially concerning given their democratic role. Yet, public librarians have boldly stood up to these anti-democratic efforts. This thesis provides an explanation for why public librarians have been successful and forceful in responding to such threats: public libraries’ democratic, resilient, and unwavering organizational culture. Specifically, the cultural tenets of professional ethics, intellectual freedom, and inclusivity, which have developed since the establishment of American public libraries to become central components of libraries’ organizational culture, have made public librarians successful.
The thesis first explores how each of these three tenets of public librarianship have been established over the course of its history to become the deeply ingrained cultural values that they are today. The thesis then uses Pella Public Library in Pella, Iowa as a case study to demonstrate how, when combined, professional ethics, intellectual freedom, and inclusivity have aided public libraries in successfully responding to politicization by creating a resilient, unwavering, and democratic organizational culture. To analyze public libraries’ organizational culture, Edgar and Peter Schein’s framework of cultural analysis is employed to evaluate culture at three levels: artifact, espoused values, and underlying assumptions
The economic impacts of Oregon's south coast restoration industry
No full textThis archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF cover (viewed on December 24, 2013)Includes bibliographical references (pages 40-41)This research was made possible with support from The Freshwater Trust and the Wild Rivers Coast AllianceMode of access: Internet from the Oregon Government Publications Collection
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