1,126 research outputs found
Peter H. Schuck. — Suing Government. Citizen Remedies for Official Wrong
No full textCoyle Dauphin Joanne. Peter H. Schuck. — Suing Government. Citizen Remedies for Official Wrong. In: Revue Française d'Etudes Américaines, N°20, mai 1984. Sexualité, érotisme dans la littérature américaine. p. 300
Peter H. Schuck. — Suing Government. Citizen Remedies for Official Wrong
No full textCoyle Dauphin Joanne. Peter H. Schuck. — Suing Government. Citizen Remedies for Official Wrong. In: Revue Française d'Etudes Américaines, N°20, mai 1984. Sexualité, érotisme dans la littérature américaine. p. 300
Replication Data for: Diversity of Short Linear Interaction Motifs in SARS-CoV-2 Nucleocapsid Protein
No full textMolecular mimicry of short linear interaction motifs has emerged as a key mechanism for viral proteins binding host domains and hijacking host cell processes. Here, we examine the role of RNA-virus sequence diversity in the dynamics of the virus-host interface, by analyzing the uniquely vast sequence record of viable SARS-CoV-2 species with focus on the multi-functional nucleocapsid protein. We observe the abundant presentation of motifs encoding several essential host protein interactions, alongside a majority of possibly non-functional and randomly occurring motif sequences absent in subsets of viable virus species. A large number of motifs emerge ex nihilo through transient mutations relative to the ancestral consensus sequence. The observed mutational landscape implies an accessible motif space that spans at least 25% of known eukaryotic motifs. This reveals motif mimicry as a highly dynamic process with the capacity to broadly explore host motifs, allowing the virus to rapidly evolve the virus-host interface
Replication Data for: An automated interface for sedimentation velocity analysis in SEDFIT
No full textThe datasets provide source data for this study. Software can be downloaded from sedfitsedphat.nibib.nih.gov/software. Abstract: Sedimentation velocity analytical ultracentrifugation (SV-AUC) is an indispensable tool for the study of particle size distributions in biopharmaceutical industry, for example, to characterize protein therapeutics and vaccine products. In particular, the diffusion-deconvoluted sedimentation coefficient distribution analysis, in the software SEDFIT, has found widespread applications due to its relatively high resolution and sensitivity. However, a lack of suitable software compatible with Good Manufacturing Practices (GMP) has hampered the use of SV-AUC in this regulatory environment. To address this, we have created an interface for SEDFIT so that it can serve as an automatically spawned module with controlled data input through command line parameters and output of key results in files. The interface can be integrated in custom GMP compatible software, and in scripts that provide documentation and meta-analyses for replicate or related samples, for example, to streamline analysis of large families of experimental data, such as binding isotherm analyses in the study of protein interactions. To test and demonstrate this approach we provide a MATLAB script mlSEDFIT
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Limits Of Law ::Essays On Democratic Governance /
No full textLaw is an increasingly pervasive force in our society. At the same time, however, the obstacles to laws effectiveness are also growing. In The Limits of Law, Yale law professor Peter H. Schuck draws on law, social science, and history to explore this momentous clash between laws compelling promise of ordered liberty and the realistic limits of its capacity to deliver on this promise. Schuck first discusses the constraints within which law must worklaws own complexity, the cultural chasms it must bridge, and the social diversity it must accommodateand proceeds to consider the ways law uses regulatory, legislative, and adjudicatory processes to influence social behavior. He shows how politics shapes regulation, how regulation might incorporate individualized equity, and how it can best be reformed. Turning to legislation, he justifies a strong role for special interest groups, dissects the anatomy of purely symbolic statutes, and defends broad delegations of legislative power to regulatory agencies. On adjudication, Schuck analyzes the courts efforts to advance social justice by controlling federal agencies, constitutionalizing politics, managing mass toxic tort disputes, and reforming public services and institutions. His concluding chapter draws together some general lessons about laws limits and possibilities for improving democratic governance
Appartenance à la société libérale et dévaluation de la citoyenneté américaine
No full textMembership in the liberal polity: the devaluation of American citizenship
Peter H. SCHUCK
National citizenship, which limits legal and political rights, coexists in tension with a liberal ethos, which celebrates universal human rights. In the US, that tension has increasingly been resolved in favor of universal rights. The article explores how that resolution has proceeded. The first three sections of the article emphasize the Supreme Court's expansive interpretations of the equal protection and due process principles, which are embedded in the US Constitution, and the US's increasing weakening of mutual consent as the basis for national membership. These changes, the article argues, have effectively reduced the value of acquiring US citizenship. The final section considers whether this is desirable or not. It condudes that on balance the devaluation of citizenship is a positive development and that citizenship retains significance in a liberal polity, where it can act as a symbolic bridge between parochial loyalties and universist aspirations.L'appartenance à une société politique libérale et la dévaluation de la citoyenneté américaine
Peter H. SCHUCK
La citoyenneté, qui limite les droits politiques et ceux de l'individu en général sont en tension par rapport à l'éthique libérale qui célèbre les droits humains universels. Cet article analyse l'évolution de ce rapport de tension aux Etats-Unis, qui a été de plus en plus favorable aux droits universels. Les trois premières parties montrent comment la Cour Surpéme à interprété de plus en plus largement les principes d'égale protection et de juste traitement, qui sont inscrits dans la constitution américaine, et l'affaiblissement croissant du principe de consentement mutuel, qui est à la base de la citoyenneté américaine. Ces changements ont réduit l'attrait de l'acquisition de la citoyenneté. La dernière partie évalue cette dynamique. On conclut qu'au total, la dévaluation de la citoyenneté est un fait plutôt positif, et qu'elle garde un sens dans une société libérale, car elle peut constituer un pont symbolique entre les loyautés paroissiales et les aspirations universelles.La pertenencia a una sociedad política liberal y la devaluación de la ciudadanía norteamericana
Peter H. SCHUCK
La ciudadanía que limita los derechos políticos y los del individuo en general, está en tensión respecto a la ética liberal que celebra los derechos humanos universales. Este artículo analiza la evolución de esta tensión en Estados-Unidos, que ha sido cada vez más favorable a los derechos universales. Las tres primeras partes muestran como la Corte Suprema intepretó cada vez más ampliamente los principios de igual protección y de justo tratamiento, inscritos en la constitución norteamericana, y el debilitamiento creciente del principio de consentimiento mutuo, base de la ciudadanía norteamericana. La última parte estudia como esos cambios han reducido el atractivo de la adquisición de la ciudadanía. Se concluye que al fin y al cabo, la devaluación de la ciudadanía es un hech más bien positivo y que conserva un sentido en una sociedad liberal, porque puede constituir un puente simbólico entre las lealtades parroquiates y las aspiraciones universales.Schuck Peter H. Appartenance à la société libérale et dévaluation de la citoyenneté américaine. In: Revue européenne des migrations internationales, vol. 6, n°1,1990. L'immigration aux États-Unis. pp. 93-110
Assessing Peter Schuck\u27s Diversity in America: Keeping Government at a Safe Distance - Introduction
No full textPeter Schuck\u27s Diversity In America: Keeping Government at a Safe Distance makes a thoughtful and provocative contribution to debate over the value of diversity in society and how government should regulate it. He argues that while diversity is a valuable resource, government should play a limited role in managing it, protecting diversity where it exists but not actively promoting it. Thus, he supports laws that protect existing or emerging diversity-such as laws against discrimination in education, employment, and housing-while criticizing government policies that seek to create, certify, or cultivate diversity-such as government-mandated affirmative action, diversity visas, and most forms of bilingual education
Lawyers and Policymakers in Government
No full textSchuck discusses the conflicts in policymaking that occurred between the office of the ASPE (Assistant Secretary for Planning and Evaluation) and the Secretary of the Department of Health, Education, and Welfare, Joseph A. Califano. Califano believed that only lawyers were fit policymakers and everyone else was a mere technician
When the Exception Becomes the Rule: Regulatory Equity and the Formulation of Energy Policy Through an Exceptions Process
No full textRegulatory programs exacerbate the inherent conflict between the values associated with rules and with equity. This conflict is especially acute in programs, like petroleum price and allocation regulation, that regulate complex transactions between diverse firms in a volatile market. Professor Schuck examines one technique for achieving regulatory equity-an exceptions process-in that context. After exploring the different limitations of rules and the relationship between regulatory equity and related concepts, including discretion, judicial equity and agency adjudication, Professor Schuck presents four detailed case studies of the exceptions process in petroleum regulation. He demonstrates that the exceptions process did enhance regulatory equity in that program but also jeopardized important administrative law values
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