656 research outputs found
Out There 3
No full textContributors: Henry Kanabus, Ted Berrigan, Bob Rosenthal, Andrei Codrescu, Neil Hackman, Tom Veitch, Barry Schecter, Steve Levine, Bernadette Mayer, Simon Schuchat, John Weiners, Peter Kostakis, Rochelle Kraut,https://neiudc.neiu.edu/outthere/1002/thumbnail.jp
Out There 1
No full textContributors: Peter Kostakis, Alice Notley, Neil Hackman, Tom Mandel, Maxine Chernoff, Bob Rosenthal, Alan Axelrod, Simon Schuchat, Daniel Cleary, Ted Berrigan, Art Lange, Bill Knott, Richard Friedman, Shelley Kraut, Laura Lasworthhttps://neiudc.neiu.edu/outthere/1000/thumbnail.jp
Out There 2
No full textContributors: Curtis Faville, George Mattingly, Bob Rosenthal, Anne Waldman, Paul Hoover, Tom Raworth, Allan Kornblum, Richard Friedman, Gerard Malanga, Steve Toth, Neil Hackman, Peter Kostakis, Don Cameron, Sheila Heldenbrand, Gail Angellhttps://neiudc.neiu.edu/outthere/1001/thumbnail.jp
Speaking of Books… Connecting with Faculty through a Campus Author Series
No full textA faculty author speaker series is an effective way to build bridges between academic librarians and the teaching faculty, as well as raise the profile of the university library. To explore the challenges and rewards of hosting such a series, this article presents a history of the series “Speaking of Books… Conversations with Campus Authors” at the University of Maryland. It discusses the details of planning and executing author events, in the hope that others can use this information to host their own lecture series. Finally, it presents a few ideas for future directions of the faculty author series.https://southernlibrarianship.icaap.org/content/v10n01/hackman_t01.htm
Speaking of Books... Connecting with Faculty through a Campus Author Series
No full textA faculty author speaker series is an effective way to build bridges between academic librarians and the teaching faculty, as well as raise the profile of the university library. To explore the challenges and rewards of hosting such a series, this article presents a history of the series "Speaking of Books… Conversations with Campus Authors" at the University of Maryland. It discusses the details of planning and executing author events, in the hope that others can use this information to host their own lecture series. Finally, it presents a few ideas for future directions of the faculty author series
HPRT mutational spectra and microsatellite DNA instability in HNPCC and lung cancer patients
No full textThe, general aims of this work have been to explore the use of microsatellite DNA length variation and mutational spectra of the hypoxanthine guanine phosphoribosyltransferase (HPRT) locus in T-cells as tools for a better understanding of human somatic mutagenesis in vivo. In particular (a) how inherited mismatch repair (MMR) deficiency may affect the stability of microsatellite DNA and the mutational spectrum at the HPRT locus, and (b) how the mutational spectrum at the HPRT locus is influenced by smoking, and by predisposition to lung cancer among never smokers. Microsatellite DNA length variation (MSDLV) was studied in DNA from T-cell clones and peripheral blood lymphocytes, using suitable markers for PCR analysis and polyacrylamide gel electrophoresis. T-cell cloning in medium containing 6-thioguanine was used to select for HPRT mutant clones, and the mutations were further classified and characterised by PCR-based methods and DNA sequencing.The background frequency of MSDLV in peripheral lymphocytes was determined using three microsatellite markers (D2S123, D9S180, D10S197). 3 out of 1028 alleles studied in T-cell clones of normal healthy subjects, showed altered microsatellite size compared to other clones from the same individual. Thus the background MSDLV was estimated to 2.9 x 10-3. We then analysed the MSDLV and HPRT mutant frequency (MF) in a breast cancer patient belonging to a hereditary nonpolyposis colorectal carcinoma (HNPCC) family, with two different mutations in her hMLH1 genes. This compound heterozygote showed a frequency of microsatellite length variation of 18.9 % per allele, which was 50 times higher than the background frequency. The HPRT MF of 34.5 x 10-6 was elevated 2-3 times compared to controls. The HPRT mutational spectrum of this patient was significantly different from normal, with a shift from base pair substitutions towards frameshifts, especially + 1bp insertions, and deletions. Also two new basepair mutations not reported earlier were seen and two of the clones studied had two mutations each, which is very unusual. We concluded that the patient was likely to have a mild MMR deficiency in her somatic cells due to the mutations in both of her hMLH1 genes, and that this was the cause of her microsatellite instability (MSI), increased HPRT MF and abnormal HPRT mutational spectrum. The HPRT mutational spectrum was studied in 73 T-cell clones each from smoking and nonsmoking lung cancer patients. The proportions of different types of mutations, were not significantly different between smokers and nonsmokers, although the smokers had less deletions. The distribution of basepair substitutions was nonrandom, with clustering at previously identified hotspots at positions 143, 197 and 617 of the HPRT coding sequence. One additional hotspot at position 606 was observed, in smokers only. The frequency of GC>TA transversions (13%) was higher in smokers than in nonsmokers (6%). Conversely smokers had a lower frequency of GC>AT transitions (24 %) than nonsmokers (35 %).We concluded that there was a minor effect of smoking on the HPRT mutational spectra, with a trend for increase of GC>TA transversions and decrease of GC>AT transitions, in the smokers compared to the nonsmokers. This is consistent with the in vitro mutagenicity of benzo(a)pyrene, one of the prominent carcinogens of tobacco smoke. In conclusion, these results show that analysis of HPRT mutations may contribute to the understanding of somatic mutagenesis in vivo, and that the mutational spectrum at the HPRT locus may reflect abnormalities of repair and extensive environmental exposure, such as tobacco smoking.List of scientific papersI. Hackman P, Gabbani G, Österholm AM, Hellgren D, Lambert B. (1995). Spontaneous length variation in microsatellite DNA from human T-cell clones. Genes Chromosomes Cancer. 14(3):215-219. https://pubmed.ncbi.nlm.nih.gov/8589039II. Hackman P, Tannergård P, Osei-Mensa S, Chen J, Kane MF, Kolodner R, Lambert B, Hellgren D, Lindblom A. (1997). A human compound heterozygote for two MLH1 missense mutations. Nat Genet. 17(2):135-136. https://pubmed.ncbi.nlm.nih.gov/9326924III. Hackman P, Lindblom A, Nyström M, Marra G, Nicolova T, Lambert B (2000). Compound hMlH1 heterozygosity associated with abnormal spectrum of somatic mutations in a breast cancer patient belonging to a HNPCC family. [Manuscript]IV. Hackman P, Hou SM, Nyberg F, Pershagen G, Lambert B (2000). Mutational spectra at the Hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus in T-lymphocytes of non-smoking and smoking lung cancer patients. Mutat Res. 468(1):45-61. https://pubmed.ncbi.nlm.nih.gov/10863157</p
Looking for Genres on the World Wide Web: Content Analysis of American Author Web Sites
No full textPoster and handouts for presentation at American Library Association Annual Conference, Chicago, July 11, 2009.This project entails content analysis of 200 websites for authors commonly taught in university-level American literature survey courses. Using a faceted classification scheme to categorize site content, the researchers explore the extent to which consistency has developed in the scope and content of Web sites for authors in the canon of American literature. The goal is to identify both the full range of unique content on these Web sites and, within that range, the core content elements that comprise the “American Author Web Site” genre. The authors also gathered biographical details on each author, to consider the question of whether Web site content varies by an author’s gender or racial background. Ultimately, the goal is to identify a set of common and/or “best” practices for content and organization of author Web sites that will assist both undergraduate students and advanced researchers looking for author information on the Web, as well as site designers hoping to create quality resources for these users. In the choice of subject, size of the sample, and novelty of the approach, this promises to be a unique project that will interest librarians, web developers, and literature researchers alike.https://drum.lib.umd.edu/handle/1903/941
Speaking of Books... Connecting with Faculty through a Campus Author Series
No full textJuried Paper presented at American Library Association Annual Conference in Chicago, July 12, 2009Academic librarians are continually seeking new and effective ways to work more closely with teaching faculty. Despite our best efforts, there often remains a gap between the two. Since 2006, librarians at the University of Maryland Libraries have been attempting to bridge this gap through a faculty speaker series entitled “Speaking of Books… Conversations with Campus Authors.” This series has allowed a group of librarians to work closely with individual faculty members to provide a forum for great scholarship on campus and to foster the image of the UM Libraries as a place where teaching and learning take place every day. To explore the challenges and rewards of hosting a faculty author lecture series, this presentation will begin with a brief history of the “Speaking of Books” series at the University of Maryland. It will then discuss some of the details of planning and executing author events, in the hopes that others can use this information as a primer for how to host their own lecture series. Finally, it will present a few ideas for future directions of such a series.https://drum.lib.umd.edu/handle/1903/941
Looking for Genres on the World Wide Web: Content Analysis of American Author Web Sites
No full textPoster and handouts for presentation at American Library Association Annual Conference, Chicago, July 11, 2009.This project entails content analysis of 200 websites for authors commonly taught in university-level American literature survey courses. Using a faceted classification scheme to categorize site content, the researchers explore the extent to which consistency has developed in the scope and content of Web sites for authors in the canon of American literature. The goal is to identify both the full range of unique content on these Web sites and, within that range, the core content elements that comprise the “American Author Web Site” genre. The authors also gathered biographical details on each author, to consider the question of whether Web site content varies by an author’s gender or racial background. Ultimately, the goal is to identify a set of common and/or “best” practices for content and organization of author Web sites that will assist both undergraduate students and advanced researchers looking for author information on the Web, as well as site designers hoping to create quality resources for these users. In the choice of subject, size of the sample, and novelty of the approach, this promises to be a unique project that will interest librarians, web developers, and literature researchers alike.Library Faculty Research Fun
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