407 research outputs found
Prediction of and strategies for the prevention of juvenile diabetes
No full textDr Peter G Colman$AUD 141,216.42NHMRC Project GrantsStandard Project Gran
sj-docx-1-dst-10.1177_19322968221079867 – Supplemental material for A Long-Term Evaluation of Facebook for Recruitment and Retention in the ENDIA Type 1 Diabetes Pregnancy-Birth Cohort Study
No full textSupplemental material, sj-docx-1-dst-10.1177_19322968221079867 for A Long-Term Evaluation of Facebook for Recruitment and Retention in the ENDIA Type 1 Diabetes Pregnancy-Birth Cohort Study by Kelly J. McGorm, James D. Brown, Rebecca L. Thomson, Helena Oakey, Belinda Moore, Alexandra Hendry, Peter G. Colman, Maria E. Craig, Elizabeth A. Davis, Mark Harris, Leonard C. Harrison, Aveni Haynes, Georgia Soldatos, Peter Vuillermin, John M. Wentworth, Jennifer J. Couper and Megan A. S. Penno in Journal of Diabetes Science and Technology</p
A prozone phenomenon interferes in islet cell antibody detection: Direct comparison of two methods in subjects at risk of diabetes and in insulin dependent diabetics at onset
No full textA recent international workshop documented marked interlaboratory variation in end point titers of standard islet cell antibody (ICA) positive sera. End titers were lower using a modified assay which utilizes fluorescein labeled protein A (ICA-pA) rather than fluoresceinated anti-IgG (ICA-IgG) to detect antibody binding to islets. In this study we sought to compare directly two ICA assays with respect to future development of IDDM. Sera were obtained from 26 prospectively evaluated high risk subjects identified by family screening or history of transient hyperglycemia and 12 normal controls. As expected, end point titers for ICA positive sera were 10 times greater using the ICA-IgG assay than with the ICA-pA assay. However, despite higher end point titers, the ICA-IgG assay failed to detect more 'prediabetics' and showed a prozone effect. Fourteen subjects were positive at a 1:2 dilution using the ICA-pA assay. Only 10 of these 14 were positive at a 1:2 dilution using the ICA-IgG assay but all became positive at greater sera dilutions. No normal controls were positive using either assay. A similar prozone was observed with anti-islet monoclonal antibodies A2B5 and 4F2. Sera from 14 long-standing IDDM patients (where titers of ICA may have decreased relative to time of onset of diabetes) which were negative using ICA-pA were also assayed using ICA-IgG. Five sera positive for ICA-IgG but negative for ICA-pA were identified. In addition two sera in which a prozone effect was seen with ICA-pA were identified. Our studies suggest that both diluted and undiluted sera should be assayed in order to avoid false negatives using either assay although an interfering prozone occurs more often with the ICA-IgG assay. © 1988
Contracting arrangements in agribusiness procurement practices in South Africa
No full textContracting arrangements in agribusiness procurement practices in South AfricaProcurement, contracting, agro-processing,
Complex scale-free networks with tunable power-law exponent and clustering
No full textThis article is made available through the Brunel Open Access Publishing Fund. It is distributed under a Creative Commons License (http://creativecommons.org/licenses/by/3.0/). Copyright @ 2013 Elsevier B.V.We introduce a network evolution process motivated by the network of citations in the scientific literature. In each iteration of the process a node is born and directed links are created from the new node to a set of target nodes already in the network. This set includes mm “ambassador” nodes and ll of each ambassador’s descendants where mm and ll are random variables selected from any choice of distributions plpl and qmqm. The process mimics the tendency of authors to cite varying numbers of papers included in the bibliographies of the other papers they cite. We show that the degree distributions of the networks generated after a large number of iterations are scale-free and derive an expression for the power-law exponent. In a particular case of the model where the number of ambassadors is always the constant mm and the number of selected descendants from each ambassador is the constant ll, the power-law exponent is (2l+1)/l(2l+1)/l. For this example we derive expressions for the degree distribution and clustering coefficient in terms of ll and mm. We conclude that the proposed model can be tuned to have the same power law exponent and clustering coefficient of a broad range of the scale-free distributions that have been studied empirically.EPSR
A treatise on chemistry /
No full textVols. 1-2: New ed. completely rev. by Sir H. E. Roscoe, assisted by Drs. H. G. Colman and A. Harden.I. The non-metallic elements. [3d ed.] 1895.--II. The metals [3d ed.] 1898.--III. The chemistry of the hydrocarbons and their derivatives, or Organic chemistry: pt. I, 1888; pt. II [2d ed.] 1887; pt. III 1887; pt. IV 1888; pt. V, 1889; pt. VI, 1892.Mode of access: Internet
Gut Virome Dynamics during Pregnancy in Mothers with Type 1 Diabetes
No full textSession LB-192 - Late Breaking Poster SessionKi Wook Kim, Digby W. Allen, Thomas Briese, Chi Nam Pang, Komal Jain, Jessica L. Horton, Sonia R. Isaacs, Marc R. Wilkins, Jennifer Couper, Megan A.S. Penno, Leonard C. Harrison, Grant Morahan, Mark Harris, Andrew M. Cotterill, Claire Morbey, Simon C. Barry, Aveni Haynes, Elizabeth Davis, Peter Colman, Lynne Giles, Jodie Dodd, John Wentworth, Richard Sinnott, Tony A. Papenfuss, Peter Vuillermin, W. Ian Lipkin, William D. Rawlinson, Maria E. Crai
Assay for cytoplasmic islet cell antibodies using two-color immunofluorescence and rat pancreas
No full textRadical Reversals: Commerce and Natural Rights in John Thelwall's Farce _Inkle and Yarico, or Ingratitude Rewarded_ (1787)
No full textIn the early months of 1787, young John Thelwall (1761-1834) submitted the manuscript of a two-act farce to George Colman, the well-known playwright and manager of the Haymarket Theatre. A sharp satire of British commercial spirit, institutions and urban culture, the play was silently dismissed, and only returned to its author in 1814. Its tremendously popular subject, however, was reshaped into one of the most successful comic operas of its time, _Inkle and Yarico_, which was penned by the manager’s son, George Colman the Younger, and premiered on August 4 of that same year at Haymarket. In this essay, I will consider how Thelwall’s brief and incisive play encapsulates John Thelwall’s radical politics, exposing the inconsistencies underlying British mercantile ethos, and questioning its very foundations
Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes
No full textMembers of ENDIA Study Group: Peter Baghurst, Simon Barry, Jodie Dodd, Maria Makrides for the University of Adelaide.BACKGROUND The incidence of type 1 diabetes has increased worldwide, particularly in younger children and those with lower genetic susceptibility. These observations suggest factors in the modern environment promote pancreatic islet autoimmunity and destruction of insulin-producing beta cells. The Environmental Determinants of Islet Autoimmunity (ENDIA) Study is investigating candidate environmental exposures and gene-environment interactions that may contribute to the development of islet autoimmunity and type 1 diabetes. METHODS/DESIGN ENDIA is the only prospective pregnancy/birth cohort study in the Southern Hemisphere investigating the determinants of type 1 diabetes in at-risk children. The study will recruit 1,400 unborn infants or infants less than six months of age with a first-degree relative (i.e. mother, father or sibling) with type 1 diabetes, across five Australian states. Pregnant mothers/infants will be followed prospectively from early pregnancy through childhood to investigate relationships between genotype, the development of islet autoimmunity (and subsequently type 1 diabetes), and prenatal and postnatal environmental factors. ENDIA will evaluate the microbiome, nutrition, bodyweight/composition, metabolome-lipidome, insulin resistance, innate and adaptive immune function and viral infections. A systems biology approach will be used to integrate these data. Investigation will be by 3-monthly assessments of the mother during pregnancy, then 3-monthly assessments of the child until 24 months of age and 6-monthly thereafter. The primary outcome measure is persistent islet autoimmunity, defined as the presence of autoantibodies to one or more islet autoantigens on consecutive tests. DISCUSSION Defining gene-environment interactions that initiate and/or promote destruction of the insulin-producing beta cells in early life will inform approaches to primary prevention of type 1 diabetes. The strength of ENDIA is the prospective, comprehensive and frequent systems-wide profiling from early pregnancy through to early childhood, to capture dynamic environmental exposures that may shape the development of islet autoimmunity. TRIAL REGISTRATION Australia New Zealand Clinical Trials Registry ACTRN12613000794707.Megan AS Penno, Jennifer J Couper, Maria E Craig, Peter G Colman, William D Rawlinson, Andrew M Cotterill, Timothy W Jones, Leonard C Harrison and ENDIA Study Grou
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