624 research outputs found
Gene set analysis for interpreting genetic studies
No full textInterpretation of genome-wide association study (GWAS) results is lacking behind the discovery of new genetic associations. Consequently, there is an urgent need for data-driven methods for interpreting genetic association studies. Gene set analysis (GSA) can identify aetiologic pathways and functional annotations and may hence point towards novel biological insights. However, despite the growing availability of GSA tools, the sizeable amount of variants identified for a vast number of complex traits, and many irrefutably trait-associated gene sets, the gap between discovery and interpretation remains. More efficient interpretation requires more complete and consistent gene set representations of biological pathways, phenotypes and functional annotations. In this review, I examine different types of gene sets, discuss how inconsistencies in gene set definitions impact GSA, describe how GSA has helped to elucidate biology and outline potential future directions.</p
Tuning Transitions in Rotating Rayleigh-Bénard Turbulence
No full textRayleigh-Bénard convection is a canonical system for the investigation of buoyancy-driven natural convection phenomena which abound in nature and technology. Under the influence of rotation and depending on the system parameters, the flow exhibits different regimes with disparate heat transfer characteristics even in the turbulent state. The present study attempts to tune the transitions between these regimes and thus control the heat transfer in practical applications. In particular, we explore the effect of addition of neutrally-buoyant thermally-conducting particles to the fluid. Following an experimental approach, we study the flow structure and heat transfer as functions of particle concentration and system parameters
John Wesley and Methodist music in the eighteenth century : principles and practice
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
Influence of Cation (RE = Sc, Y, Gd) and O/H Anion Ratio on the Photochromic Properties of REO<sub>x</sub>H<sub>3-2x</sub> Thin Films
No full textRare-earth oxyhydride REOxH3-2x thin films prepared by air-oxidation of reactively sputtered REH2 dihydrides show a color-neutral, reversible photochromic effect at ambient conditions. The present work shows that the O/H anion ratio, as well as the choice of the cation, allow to largely tune the extent of the optical change and its speed. The bleaching time, in particular, can be reduced by an order of magnitude by increasing the O/H ratio, indirectly defined by the deposition pressure of the parent REH2. The influence of the cation (RE = Sc, Y, Gd) under comparable deposition conditions is discussed. Our data suggest that REs of a larger ionic radius form oxyhydrides with a larger optical contrast and faster bleaching speed, hinting to a dependency of the photochromic mechanism on the anion site-hopping.ChemE/Materials for Energy Conversion and StorageRST/Fundamental Aspects of Materials and EnergyChemE/Chemical Engineerin
Genetic mapping of etiologic brain cell types for obesity
No full textThe underlying cell types mediating predisposition to obesity remain largely obscure. Here, we integrated recently published single-cell RNA-sequencing (scRNA-seq) data from 727 peripheral and nervous system cell types spanning 17 mouse organs with body mass index (BMI) genome-wide association study (GWAS) data from >457,000 individuals. Developing a novel strategy for integrating scRNA-seq data with GWAS data, we identified 26, exclusively neuronal, cell types from the hypothalamus, subthalamus, midbrain, hippocampus, thalamus, cortex, pons, medulla, pallidum that were significantly enriched for BMI heritability (p</p
MetaRanker 2.0: a web server for prioritization of genetic variation data
No full textMetaRanker 2.0 is a web server for prioritization of common and rare frequency genetic variation data. Based on heterogeneous data sets including genetic association data, protein–protein interactions, large-scale text-mining data, copy number variation data and gene expression experiments, MetaRanker 2.0 prioritizes the protein-coding part of the human genome to shortlist candidate genes for targeted follow-up studies. MetaRanker 2.0 is made freely available at www.cbs.dtu.dk/services/MetaRanker-2.0
Derogation on the EU Nitrates Directive: does it make a difference?
No full textThe paper discusses an ex ante evaluation of the derogation on the Nitrates Directive for Flanders, Belgium, which is a case of intensive but highly productive livestock areas. The aim is to develop an accurate simulation model to detect small differences in manure surpluses caused by changes of manure production and/or utilization. The system of models consists of various modules to fine tune the calculations of manure production, fertilizing behaviour and manure allocation and disposal on and off farm. The results show that derogation may cause the existing manure surpluses to expire, if only nitrogen limits are considered and no transactions costs are taken into account. When also phosphate fertilization limits are considered, the increase in manuring possibilities is much lower than expected. Ongoing research focuses on the marginal shifts in manure surplus at farm level and possible effects of transactions costs.Nitrates Directive, derogation, modelling, Environmental Economics and Policy, Livestock Production/Industries,
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