118,007 research outputs found

    The Levi Perryman Collection, 1873-1921

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    Lease and long form, from E. W. Powell and Bob Perryman to E. L. Clark and Kate Clarke. The Clark's signed to lease two lots in Hagerman, Chaves County, Territory of New Mexico. The rent was set at $35.00 per month

    The Levi Perryman Collection, 1873-1921

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    Tax receipt for $108.90 to Levi Perryman for 1910 taxes he paid: William Linn (57 2/5 acres), A Morris (160 acres), AG. Perryman (540 acres), W.T. Williams (160 acres), L Perryman (90 7/80), Seth Cary (66 2/5), L Perryman (27 and 67 acres), E Henwoods (160 acres), L Perryman (30 acres), ET Railroad Company (20 acres), H Haddon (240 acres)

    The Levi Perryman Collection, 1873-1921

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    Letter from L. K. McCaffey, real estate, to Bob Perryman stating that an abstract of his lot in Fruitland is enclosed

    The Relaxed Complex Method: Accommodating Receptor Flexibility for Drug Design with an Improved Scoring Scheme

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    An extension of the new computational methodology for drug design, the " relaxed complex" method (J.-H. Lin, A. L. Perryman, J. R. Schames, and J. A. McCammon, Journal of the American Chemical Society, 2002, vol. 24, pp. 5632-5633), which accommodates receptor flexibility, is described. This relaxed complex method recognizes that ligand may bind to conformations that occur only rarely in the dynamics of the receptor. We have shown that the ligand-enzyme binding modes are very sensitive to the enzyme conformations, and our approach is capable of finding the best ligand enzyme complexes. Rapid docking serves as an efficient initial filtering method to screen a myriad of docking modes to a limited set, and it is then followed by more accurate scoring with the MM/PBSA (Molecular Mechanics/Poisson Boltzmann Surface Area) approach to find the best ligand - receptor complexes. The MM/PBSA scorings consistently indicate that the calculated binding modes that are most similar to those observed in the x- ray crystallographic complexes are the ones with the lowest free energies

    The Levi Perryman Collection, 1873-1921

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    Envelope for letter from G.L. Arledge to Levi Perryman for tax receipts
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