1,721,077 research outputs found
Studio degli effetti degli anticorpi monoclonali anti GXM per l'ottimizzazione della terapia della criptococcosi e valutazione del possibile utilizzo di farmaci inibitori delle proteasi, quali l'Indinavir, come anti-fungini.
No full text
Gray phenotype: enhanced fitness strategy for Candida dubliniensis
Full text linkIn this study Yue H. et al described for the first time the gray phenotype and tristable white-gray-opaque transitions in Candida dubliniensis. Here we discuss some intriguing aspects related to this virulence trait of Candida dubliniensis in comparison to Candida albicans and within the wider and complex phenotypic switch phenomenon so typical of the virulence program of these opportunistic pathogenic fungi. In particular, the relationship between the presence of gray phenotype and prevalence of Candida dubliniensis in the oral cavity of HIV-positive subjects is pointed out
Experimental models of vaginal candidiasis and inflammation
No full textThere are at least two factors that play a key role in vulvovaginal candidiasis: the massive infiltration of neutrophils and extensive presence of hyphae in the vagina. Thus it is conceivable that the dynamic of inflammatory response
starts with adherence of Candida to epithelial cells followed by release of S100A and inflammasome activation with IL-1β production and subsequent further increase of PMN migration and activation
Functional defect of natural immune system in an apparent immunocompetent patient with pulmonary cryptococcosis
No full textWe report a case of pulmonary cryptococcosis in a 21-year-old Italian female smoker with no apparent immune disorder. In this study we demonstrated that: (i) patient's neutrophils and monocytes manifested a significant reduction of killing activity against Cryptococcus neoformans as well as Candida albicans; (ii) the suppression was more pronounced in monocytes than in neutrophils; (iii) neutrophils and monocytes showed a significant impairment of TNF-alpha, IL-1beta, and nitric oxide production. These results suggest that the apparent immunocompetent host with pulmonary cryptococcosis could have specific defects in natural immune system mechanisms
Functional defect of natural immune system in an apparent immunocompetent patient with pulmonary cryptococcosis: Case Report.
No full textWe report a case of pulmonary cryptococcosis in a 21-year-old Italian female smoker with no apparent immune disorder. In this study we demonstrated that: (i) patient's neutrophils and monocytes manifested a significant reduction of killing activity against Cryptococcus neoformans as well as Candida albicans; (ii) the suppression was more pronounced in monocytes than in neutrophils; (iii) neutrophils and monocytes showed a significant impairment of TNF-alpha, IL-1beta, and nitric oxide production. These results suggest that the apparent immunocompetent host with pulmonary cryptococcosis could have specific defects in natural immune system mechanisms
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