188,635 research outputs found
Device for mHealth
No full textNowadays, wearable technology is the most promising and market growing technology. Wearable can be considered the winning card up to the mHealth sleeve. Despite mHealth born around the 2000s, only in the last lustrum, it has seen a massive diffusion both for monitoring and diagnosis. Moreover, many existing devices and products have been equipped with data transmission technologies in order to improve the capability of communicating data over the Internet by means of mobile devices (smartphone or tablet) or direct connection. Data transmission allow for communicating health data directly to physicians. This permits to monitor the patient from a distance directly from home, increasing their life quality and, in the meantime, decreasing the welfare costs. This chapter wants to be a compendium of the existing solution in term of wearable, but also non-wearable devices for mobile health. The last paragraph of the chapter reports current and future development of wearable devices, with invisible technology, smart garments, and Wearable 2.0
Antitumor Platinum(II) Hybrid Compounds Based on a Glucosylglycerol Scaffold
No full textPlatinum(II) drugs such as cisplatin, carboplatin and oxaliplatin are antineoplastic drugs
clinically available for the treatment of different kinds of cancers, including ovarian
carcinoma. However, their use is limited by the occurrence of severe systemic side effects and
resistance [1, 2]. For these reasons, the development of new platinum-based compounds
endowed with higher selectivity against cancer cells and able to overcome resistance is an
active research field. A promising strategy to pursuit these goals is the design of hybrid
platinum(II) compounds bearing bioactive ligands able to selectively target cancer cells,
improve the platinum-mediated antitumor activity and/or overcome resistance by interacting
with selected targets known for their involvement in cancer resistance [3]. In this context, due
to its peculiar structure, 2-O-β-D-glucosylglycerol (a natural compound named Lilioside B)
[4] could be efficiently used at the same time as the complexing agent of platinum(II) and as
the point of attachment of cancer involved bioactive compounds. Thus, the present
communication will show some preliminary results on the synthesis and cytotoxicity data, on
ovarian cancer cells, of a water soluble platinum(II) hybrid compound in which, similarly to
carboplatin, a properly modified 2-O-β-D-glucosylglycerol is able to complex platinum(II).
References
1. Khoury, A.; Deo, K.M.; Aldrich-Wright, J.R. J. Inorg. Biochem., 2020, 207, 111070.
2. Rottenberg, S., Disler, C., & Perego, P. Nature reviews. Cancer, 2021, 21, 37.
3. Zuccolo, M,; Arrighetti, N.; Perego, P.; Colombo, D. Curr. Med. Chem., 2022, 29, 2566.
4. Kaneda, M.; Mizutani, K.; Takahashi, Y.; Kurono, G.; Nishikawa, Y. Tetrahedron Lett., 1974, 15,
3937
Foreword to the Special issue: Challenges in Computational Mechanics
No full textForeword to the special issue of Computational Mechanics containing a selection of papers presented during a Workshop entitled “ Challenges in Computational Mechanics ” (Chairmen O. Allix, U. Perego and N. Moes), held at the ENS de Cachan in May 2006, in honor of Pierre Ladevèze on the occasion of his 60th birthday.
The contributions in this special issue are mainly focused on the themes: verification of computations and model validation; development of advanced material models
A Cannibalistic Approach to Grand Canonical Crystal Growth
No full textCanonical molecular dynamics simulations of crystal growth from solution suffer from severe finite-size effects. As the crystal grows, the solute molecules are drawn from the solution to the crystal, leading to a continuous drop in the solution concentration. This is in contrast to experiments in which the crystal grows at an approximately constant supersaturation of a bulk solution. Recently, Perego et al. [J. Chem. Phys. 2015, 142, 144113] showed that in a periodic setup in which the crystal is represented as a slab, the concentration in the vicinity of the two surfaces can be kept constant while the molecules are drawn from a part of the solution that acts as a molecular reservoir. This method is quite effective in studying crystallization under controlled supersaturation conditions. However, once the reservoir is depleted, the constant supersaturation conditions cannot be maintained. We propose a variant of this method to tackle this depletion problem by simultaneously dissolving one side of the crystal while letting the other side grow. A continuous supply of particles to the solution due to the crystal dissolution maintains a steady solution concentration and avoids reservoir depletion. In this way, a constant supersaturation condition can be maintained for as long as necessary. We have applied this method to study the growth and dissolution of urea crystal from water solution under constant supersaturation and undersaturation conditions, respectively. The computed growth and dissolution rates are in good agreement with those obtained in previous studies
Efficiency of Different Ultrasonic Surface Waves for Subsurface Flaws Detection
No full textPlate-like structures, laminates and composites are becoming increasingly common in civil engineering, aerospace, ground transportation, etc. They are often over-designed to compensate for a lack of efficient techniques for testing the initial integrity of the mechanical structures and/or for a reliable monitoring of damage and ageing.</p
Full-stack User-Centered Approach for Wearable technology design
No full textWearables are easing the transition towards a personalized medicine, bringing healthcare to anyone, anytime and anywhere by removing locational, time and other restraints, while increasing its coverage, customization and quality.
For wearable devices, the human factors are essential in all the phases; from conception to subsequent design development. Current solutions are cumbersome and, despite they are designed according to standardized guidelines, they are developed for skilled users (physicians or engineers), without taking into consideration the real actors who will use and wear them: the patients.
This paper aims to describe a new full-stack approach integrating design and technology requirements for the development of wearable systems, and applying this for a new system dedicated to rehabilitation, based on a modular textile sensing platform fitting to different users and applications
Recensione a RILA – Rassegna italiana di linguistica applicata, Num. 35, vol. 1-2, Gennaio-Agosto 2003 [Numero monografico “Il Lexical Approach: una proposta utile?”], in SILTA – Studi Italiani di Linguistica Teorica e Applicata, 33 (3)
No full textRecensione a RILA – Rassegna italiana di linguistica applicata, Num. 35, vol. 1-2, Gennaio-Agosto 2003 [Numero monografico “Il Lexical Approach: una proposta utile?”], in SILTA – Studi Italiani di Linguistica Teorica e Applicata, 33 (3).
No full textFilm language and tools
No full textThe chapter considers a selection of technical components used to tell story elements in films. It provides a definition of each and it illustrates possible audio description options based on the film Inglourious Basterds (2008, Q. Tarantino). In so doing, it insists on the importance of conveying film language through AD thus echoing other calls for a stronger focus on the text as a narrative whole and not consisting only of characters, actions and settings. This is seen as the only way to respect the aesthetic and narrative integrity of the original along with the needs of sight impaired viewers
- …
