1,721,017 research outputs found
Metodo di elettroporazione non invasiva mediate da nanotubi di carbonio e dispositivo per attuare tale metodo
No full textDispersion of multiwall carbon nanotubes in aqueous Pluronic F127 solutions for biological applications
No full textBecause mass-produced carbon nanotubes (CNTs) are strongly aggregated and highly hydrophobic, processes to make them water soluble are required for biological applications. Suspensions in surfactant solutions are often employed. Among these, Pluronic F127 appear to be highly biocompatible if used at low concentrations. Starting from these results, this work involves a systematic study to clarify the dispersion behaviour of CNTs in Pluronic F127. The results suggest a two-step process: first, the bundles disaggregate, kinetically driven by the energy supplied to the system; second, they disperse (surfactant adsorption), thermodynamically driven by the surfactant concentration. The dispersion reaction data are well fitted by a first-order kinetics reaction. By performing a pretreatment step, consisting of stirring at 70C, the achieved concentration of CNTs in solution is twice that of the traditional process. The proposed procedure provides an optimal compromise between a low Pluronic concentration and a high CNT concentration
A methodology for high precision fabrication, modification and characterization of neural interfaces
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Design criteria of neuron/electrode interface. The focused ion beam technology as an analytical method to investigate the effect of electrode surface morphology on neurocompatibility
No full text"Neurocompatibility" is a broad definition which comprises aspects of biocompatibility, chemical and physical surface properties, and biostability of an artificial substrate interfaced with a neural tissue. The main issue coming from the analysis of the state of art of neuroprosthesis and neuron/electrode interfaces is the strong influence of electrode surface morphology on neurocompatibility. Enhanced functions of neurons have been observed on nano-structured materials. This paper proposes the use of focused ion beam (FIB) technology as high precision machining technique to modify the surface morphology of an interface material. By controlling the ion milling in three dimensions, the fabrication of a surface with any predefined morphology becomes possible with nanometric precision. In vitro tests on PC12 cells cultured on surfaces with different morphologies show that the surface morphology influences the cell adhesion. Experimental results suggest an enhancement of the interaction between cells and artificial surfaces at a specific scale (tens of nanometres) which is the typical scale of cellular interaction in the extra-cellular matrix (ECM) of living organisms
Novel Smart Concepts for Designing Swimming Soft Microrobots
No full textAbstractThe development of mobile un-tethered microscale robots could revolutionize the future of medicine, since they can be conceived to move in micro-structured liquid environments, such as in inaccessible districts of the human body for performing in vivo diagnosis and therapy. However, power supply and actuation are still open issues in microrobotics, because of the lack of power sources and actuators at these scales. Considering the amazing levels of functionality exhibited by microorganisms, bioinspiration is an attractive approach to address the development of innovative solutions. The demonstration of efficient methods for building, powering and steering microscale robots are thus the first crucial steps towards such advanced systems
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