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Isolation Chemical Structure Acute Toxicity and Some Physicochemical Properties of Territrem B' from Aspergillas Ferreus
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Isolation, Chemical Structure, Acute Toxicity, and Some Physicochemical Properties of Territrem B' from Aspergillus Terreus
No full textCharacterization of Escherichia coli nitroreductase NfsB in the metabolism of nitrobenzodiazepines
No full textToxicity and Anticholinesterase Activity of the Fungal Metabolites Territrems to the Corn Earworns Heliothis Zea
No full textNMR Assigments of Territrem A, B, C and the Structure of MB2, the Major Metabolite of Territrem B by Pat Liver Micro Somal Fraction
No full textUnfractionated bone marrow cells attenuate paraquat-induced glomerular injury and acute renal failure by modulating the inflammatory response
No full textThe aim of this study was to evaluate the efficacy of unfractionated bone marrow cells (BMCs) in attenuating acute kidney injury (AKI) induced by paraquat (PQ) in a mouse model. PQ (55 mg/kg BW) was intraperitoneally injected into C57BL/6 female mice to induce AKI, including renal function failure, glomerular damage and renal tubule injury. Glomerular podocytes were the first target damaged by PQ, which led to glomerular injury. Upon immunofluorescence staining, podocytes depletion was validated and accompanied by increased urinary podocin levels, measured on days 1 and 6. A total of 5.4 x 10(6) BMCs obtained from the same strain of male mice were injected into AKI mice through the tail vein at 3, 24, and 48 hours after PQ administration. As a result, renal function increased, tubular and glomerular injury were ameliorated, podocytes loss improved, and recipient mortality decreased. In addition, BMCs co-treatment decreased the extent of neutrophil infiltration and modulated the inflammatory response by shifting from pro-inflammatory Th1 to an anti-inflammatory Th2 profile, where IL-1 beta, TNF-alpha, IL-6 and IFN-gamma levels declined and IL-10 and IL-4 levels increased. The present study provides a platform to investigate PQ-induced AKI and repeated BMCs injection represents an efficient therapeutic strategy
Clearage of Territrems by Alkaline Hydrogen Peroxide:Isolation and Chorracterization of the Aromatic Moiety of Territrems
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