404 research outputs found
Figure 1 in Large-scale snake genome analyses provide insights into vertebrate development
No full textFigure 1. Phylogeny of snakes Maximum-likelihood phylogenetic tree inferred from whole-genome sequences of 31 species. Divergence times of all nodes were estimated by r8s with whole-genome sequences using six calibration points (Figures S1I and S1J). All genomes generated in this study are in red. Maps were taken from those in a previous study.24Published as part of Peng, Changjun, Wu, Dong-Dong, Ren, Jin-Long, Peng, Zhong-Liang, Ma, Zhifei, Wu, Wei, Lv, Yunyun, Wang, Zeng, Deng, Cao, Jiang, Ke, Parkinson, Christopher L., Qi, Yin, Zhang, Zhi-Yi & Li, Jia-Tang, 2023, Large-scale snake genome analyses provide insights into vertebrate development, pp. 1-18 in Cell 186 on page 3, DOI: 10.1016/j.cell.2023.05.030, http://zenodo.org/record/807067
Mechanical response of a triply periodic minimal surface cellular structures manufactured by selective laser melting
No full textCellular structures with controllable mechanical properties and porous architecture are the most promising candidates for many applications such as bone implants. Selective laser melting (SLM), one of the additive manufacturing (AM) technologies, enables manufacturing of space filling lattice structures with exceptional load bearing efficiency, customizable stiffness, controllable cell topology, cell size, and porosity. In this work, Schoen Gyroid (SG) unit cell, a triply periodic minimal surface (TPMS) structure, was used to design the cellular structures. As opposed to many other types of unit cells, SG has superior characteristics of self-supporting and high manufacturability for AM technologies. The titanium alloy (Ti–6Al–4V) SG cellular structures were manufactured by SLM. Finite element (FE) method was employed to predict the elastic modulus, compressive yield strength and stress/strain distributions of the SG cellular structures, and the failure occurrence mechanisms were analyzed. The FE results were compared with the experimental data. The results show that through FE method, the mechanical responses of the SG cellular structures can be accurately described and it is possible to customize the mechanical properties of SLM-produced titanium alloy TPMS lattices
Figure 2 in Large-scale snake genome analyses provide insights into vertebrate development
No full textFigure 2. Evolutionary features of snake genomes (A) Chromosome evolution in snakes. A total of 23 proto-chromosomes of Serpentes were reconstructed using four lizards as outgroups (only eight species are shown here for clarity, with more species listed in Figure S2A). (B) Genome size, TE size, and TE type content in chicken, non-snake reptiles (four lizards, one turtle, and one crocodile), and snakes. (C) GC content and CpG island density of snake genomes.Published as part of Peng, Changjun, Wu, Dong-Dong, Ren, Jin-Long, Peng, Zhong-Liang, Ma, Zhifei, Wu, Wei, Lv, Yunyun, Wang, Zeng, Deng, Cao, Jiang, Ke, Parkinson, Christopher L., Qi, Yin, Zhang, Zhi-Yi & Li, Jia-Tang, 2023, Large-scale snake genome analyses provide insights into vertebrate development, pp. 1-18 in Cell 186 on page 4, DOI: 10.1016/j.cell.2023.05.030, http://zenodo.org/record/807067
Figure 4 in Large-scale snake genome analyses provide insights into vertebrate development
No full textFigure 4. Genome features associated with snake-specific sense organ evolution, highlighting PSGs, REGs, newly evolved genes, SD-CNEassociated genes, lost genes, and SSSV-associated genes (A) Lost and highly expressed genes in snake eyes. Diagram of the snake eye showing lost genes in blue. Heatmap of highly expressed genes (QN, quantile normalized). (B) Diagram of the snake inner ear. Twelve SD-CNE-associated genes and four SSSV-associated genes are involved in ear development. Expression levels (scaled fragments per kilobase per million mapped reads [FPKM]) of sound perception-related PSGs and REGs in 10 keeled slug snake (Pber) tissues are shown in circles. Circle size is positively correlated to the expression level. (C) Diagram of the taste transduction process. Solid lines indicate direct interactions, and dotted lines indicate indirect interactions. See also Table S3.Published as part of Peng, Changjun, Wu, Dong-Dong, Ren, Jin-Long, Peng, Zhong-Liang, Ma, Zhifei, Wu, Wei, Lv, Yunyun, Wang, Zeng, Deng, Cao, Jiang, Ke, Parkinson, Christopher L., Qi, Yin, Zhang, Zhi-Yi & Li, Jia-Tang, 2023, Large-scale snake genome analyses provide insights into vertebrate development, pp. 1-18 in Cell 186 on page 9, DOI: 10.1016/j.cell.2023.05.030, http://zenodo.org/record/807067
GENDER AND STATUS DIFFERENCES IN LOQUACIOUSNESS WITHIN TRAUMA TEAMS: EXPLORING CLOSED-LOOP COMMUNICATION
No full textBachelor'sBachelor of Social Sciences (Honours
A Flexible and Stretchable Self-Powered Nanogenerator in Basketball Passing Technology Monitoring
No full textThe rapid development of the fifth generation technology poses more challenges in the human motion inspection field. In this study, a nanogenerator, made by PVDF, ionic hydrogel, and PDMS, is used. Furthermore, a transparent, stretchable, and biocompatible PENG (TSB-PENG) is presented, which can be used as a self-powered sensor attached to the athlete’s joints, which helps to monitor the training and improve the subject’s performance. This device shows the ability to maintain a relatively stable output, under various external environments (e.g., inorganic salt, organic matter and temperature). Additionally, TSB-PENG can supply power to small-scale electronic equipment, such as Bluetooth transmitting motion data in real time. This study can provide a new approach to designing lossless, real-time, portable, and durable self-powered sensors in the sports motoring field
Shaws' sea snake genome project
No full textThese datasets include data files of the Shaw's sea snake genome assembly and gene expressions in venom gland of selected snakes.Shaw's sea snake genome assembly: Hcur1.v1.1.fa.gzShaw's sea snake genome assembly coding genes annotations: Hcur1-v1.1.gff3.gz FPKM of genes in selected snakes's venom glands: Gene_expressions_venom_gland.rar FPKM of toxin genes in selected snakes venom glands: Expressions_of_toxinGenes.rar </div
Artery tertiary lymphoid organs control multi-layered territorialized atherosclerosis B cell responses in aged ApoE-/- mice
No full textObjective: Explore aorta B cell immunity in aged ApoE-/- mice.
Approach and Results: Transcript maps, FACS, immunofluorescence analyses, cell transfers, and Ig-ELISPOT assays showed multi-layered atherosclerosis B cell responses in artery tertiary lymphoid organs (ATLOs). Aging-associated aorta B cell-related transcriptomes were identified and transcript atlases revealed highly territorialized B cell responses in ATLOs versus atherosclerotic lesions: ATLOs showed upregulation of bona fide B cell genes including Cd19, Ms4a1 (Cd20), Cd79a/b, and Ighm though intima plaques preferentially expressed molecules involved in non-B effector responses towards B cell-derived mediators, i.e. Fcgr3 (Cd16), Fcer1g (Cd23), and the C1q family. ATLOs promoted B cell recruitment. ATLO B-2 B cells included naïve, transitional, follicular, germinal center, switched IgG1+, IgA+, and IgE+ memory cells, plasmablasts, and long-lived plasma cells (PCs). ATLOs recruited large numbers of B-1 cells whose subtypes were skewed towards IL-10+ B-1b cells versus IL-10- B-1a cells. ATLO B-1 cells and PCs constitutively produced IgM and IgG and a fraction of PCs expressed IL-10. Moreover, ApoE-/- mice showed increased germinal center B cells in renal lymph nodes, IgM-producing PCs in the bone marrow, and higher IgM and anti-MDA-LDL IgG serum titers.
Conclusions: ATLOs orchestrate dichotomic, territorialized, and multi-layered B cell responses in the diseased aorta; germinal center reactions indicate generation of autoimmune B cells within the diseased arterial wall during aging
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