1,952 research outputs found
C.S. Lewis: Reactions from Women
No full textRecounts the experiences of eight women (including the author) who knew C.S. Lewis
C.S. Lewis’s theory of Sehnsucht as a tool for theorizing L.M. Montgomery’s experience of ‘The Flash'
No full textHigh-k fluoropolymers dielectrics for low-bias ambipolar organic light emitting transistors (Olets)
No full textFunding Information: Author Contributions: Conceptualization, A.A. and C.S.; methodology, A.A. and C.S.; validation, A.A., K.G.-R., and C.S.; data curation, A.A., K.G.-R., and C.S.; writing—original draft preparation, A.A. and C.S.; writing—review and editing, A.A., K.G.-R., and C.S.; supervision, C.S.; project administration, C.S.; funding acquisition, C.S. All authors have read and agreed to the published ver-sion ofFunding:the manuThescript.authors acknowledge the support from the Academy of Finland Flagship Program (Grant No.: 320167, PREIN) and the Aalto seed funding scheme. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Organic light emitting transistors (OLETs) combine, in the same device, the function of an electrical switch with the capability of generating light under appropriate bias conditions. In this work, we demonstrate how engineering the dielectric layer based on high-k polyvinylidene fluoride (PVDF)-based polymers can lead to a drastic reduction of device driving voltages and the improvement of its optoelectronic properties. We first investigated the morphology and the dielectric response of these polymer dielectrics in terms of polymer (P(VDF-TrFE) and P(VDF-TrFE-CFE)) and solvent content (cyclopentanone, methylethylketone). Implementing these high-k PVDF-based dielectrics enabled low-bias ambipolar organic light emitting transistors, with reduced threshold voltages (<20 V) and enhanced light output (compared to conventional polymer reference), along with an overall improvement of the device efficiency. Further, we preliminary transferred these fluorinated high-k dielectric films onto a plastic substrate to enable flexible light emitting transistors. These findings hold potential for broader exploitation of the OLET platform, where the device can now be driven by commercially available electronics, thus enabling flexible low-bias organic electronic devices.Peer reviewe
Probabilistic Solutions to Merchant Problems: Locating of the False Stack
No full textIn [1] a probabilistic solution to the Infinite Merchant's Problem, an undecidable problem equivalent to the Halting Problem, was proposed. The solution uses a real Hilbert space and is based on the estimation of the exponential growth of an unbounded semigroup. In [2] was offered an alternative solution in terms of scattering processes on quantum dots. The authors reduced the problem to a special scattering problem and testify the "halting phenomenon" based on the quantum measurement of results of scattering with random input data. The a-posteriori probability of halting, subject to the negative results of multiple independent tests, was estimated. The possibility of location the number of the bag with false coins in finite-dimensional case was noticed in [1] and proved in [2]. The aim of this paper is to offer a solution of the latter problem in the infinite case. [1] C.S. Calude, B.S. Pavlov. Coins, quantum measurements, and Turing's barrier, Quantum Information Processing, 1, 1--2 (2002), 107--127. [2] V.A. Adamyan, C.S. Calude, B.S. Pavlov, A quantum scattering approach to undecidable problem. In: Quantum information and complexity, Proceedings of the Meijo Winter School 2003, Meijo University, Nagoya, Japan, 6 - 10 January 2003, edited by T Hida, K Saitô (Meijo University, Japan) and Si Si (Aichi Prefectural University, Japan)
Essential phospholipids for people with non-alcoholic fatty liver disease (Protocol)
No full textNon-alcoholic fatty liver disease (NAFLD) covers conditions related to accumulation of fat in the liver if specific causes, such as significant alcohol consumption, long-term use of a steatogenic medication, or monogenic hereditary disorders can be excluded (WGO 2014). Non-alcoholic fatty liver disease features a wide spectrum of histologically conditions, from simple accumulation of fat ('fatty liver' or hepatic steatosis) to non-alcoholic steatohepatitis (NASH), liver fibrosis, and liver cirrhosis with clinical consequences (Brunt 2011; McPherson 2015; Bertot 2016). Simple hepatic steatosis is defined as when the fat, built up in the epithelial cells of the liver, is at least 5% of the liver weight, and the parenchymal cells and liver structure are intact. Non-alcoholic fatty liver (NAFL) is defined as the presence of hepatic steatosis with no evidence of hepatocellular injury in the formof ballooning of the hepatocytes. Non-alcoholic steatohepatitis is defined as the presence of hepatic steatosis and inflammation with hepatocyte injury (ballooning) with or without fibrosis (Brunt 2011). Nonalcoholic fatty liver disease is considered to be a clinical manifestation of the metabolic syndrome, that is the co-occurrence of metabolic risk factors for both type 2 diabetes and cardiovascular disease (abdominal obesity, hyperglycaemia, dyslipidaemia, and hypertension) (Dyson 2014;Mikolasevic 2016; AASLD NAFLD 2018). The prevalence of NAFLD is increasing, but only a small number of affected people develop inflammation, which may be followed by fibrosis and cirrhosis, possibly requiring liver transplantation (Bertot 2016; Younossi 2016). The life expectancy in people with hepatic steatosis is reported to be similar to the life expectancy of the general population (Lazo 2011)
C.S. Lewis: adaptations of life and work
No full textThe author discusses film representations of the life of C.S. Lewis – a famous English Christian writer. She also focuses on adaptations (that include books, television and cinema) of his most famous series The Chronicles of Narnia – series that for already sixty years have been published all over the world
Systematic review with meta-analysis : Diagnostic accuracy of transient elastography for staging of fibrosis in people with alcoholic liver disease
No full textBackground The progression of hepatic fibrosis into cirrhosis is a main prognostic factor for survival in people with alcoholic liver disease. The range of cut-off values characterising the stage of hepatic fibrosis seems to be dependent on the aetiology of the liver disease. Aims To determine the diagnostic accuracy of transient elastography (the index test) for diagnosis of fibrosis in alcoholic liver disease when compared with liver biopsy (the reference standard), using the METAVIR scoring system. To establish the optimal cut-off values for the hepatic fibrosis stages. Methods We followed Cochrane Methodology for diagnostic test accuracy reviews. We identified 14 studies. Among the study participants with alcoholic liver disease, 834 provided numerical data for analysis (August 2014). Only half of the studies were monoaetiology studies. We used the bivariate model and estimated the summary sensitivities and summary specificities. Hence, we calculated the summary likelihood ratios (LRs) to rule in or rule out hepatic fibrosis. We investigated pre-defined sources of heterogeneity. Results Severe fibrosis (F3 or worse): summary (95% CI) sensitivity 0.92(0.89-0.96) and specificity 0.70(0.61-0.79); LR+ 3.1(2.1-4.1), LR- 0.11(95% CI 0.06-0.16). Cirrhosis (F4): summary (95% CI) sensitivity of 0.95(0.87-0.98) and specificity 0.71(0.56-0.82); LR+ 3.3(2.1-5.0); LR- 0.07(0.03-0.19). Conclusions Transient elastography may be used as a diagnostic method to exclude cirrhosis or severe fibrosis when the test is negative. Cut-off values of around 12.5 kPa for cirrhosis may be used in clinical practice, but caution is needed, as the values reported in the review are not yet prospectively validated
Letter to the Editor: Glucocorticosteroids for alcoholic for alcoholic hepatitis
No full textOur Cochrane systematic review on glucocorticosteroids versus placebo or no intervention for people with alcoholic hepatitis found no evidence of a difference on clinically important outcomes at either of the three timepoints of follow-up.(4) Our review (last search 18.01.2019) was based on a pre-published, peer-reviewed protocol. In a subgroup meta-analysis of 14 trials with 1679 participants with severe alcoholic hepatitis, we found no evidence of effect of glucocorticosteroids on mortality.(4)
The Nurse of Elfland: Lizzie Endicott and C.S. Lewis
No full textIn Surprised by Joy, C.S. Lewis introduced Lizzie Endicott as the first of two other blessings in his childhood, even before his introduction of Warnie. But apart from his abbreviated 136-word biography, very little is known about the nurse who introduced Lewis to faery tales. Based on the Lewis Family Papers, genealogical research, and personal interviews with Lizzie’s relatives, this article introduces Lizzie to the world of Lewismania. It also suggests various ways in which Lizzie influenced the man and the author that C.S. Lewis became, as well as the mythical worlds he created and Lewis’s anonymous tributes to her
Remembering C.S. Lewis recollections of those who knew him
No full textIn this intimate, candid, and sometimes surprising community biography of the celebrated author and Christian apologist, twenty-four men and women who knew C.S. Lewis, as teacher, colleague, friend, offer their reminiscences and impressions of the complex man behind the critical and academic acclaim
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