17,301 research outputs found
An Article About Albertus C. Van Raalte, Author Unknown, Except for Parts Taken from an Article by Anna C. Post
No full textAn article about Albertus C. Van Raalte, author unknown, except for parts taken from an article by Anna C. Post. The author knew first generation persons in the Holland settlement and therefore, the article has some value.https://digitalcommons.hope.edu/vrp_1890s/1012/thumbnail.jp
In vitro cell models merging circadian rhythms and brain waves for personalized neuromedicine
No full textNew evidence is emerging about the dynamics of interaction between circadian rhythms and brain waves, whose coordination occurs through the entrainment process. The so-called “oscillopathies” or dysfunctions in synchronization of neuronal oscillation in key brain networks lead to the onset of neurodegenerative diseases. A typical example of alteration is insomnia, a risk factor for the oscillopathies, increasingly widespread worldwide. Recently, synchronization of circadian rhythms in cell cultures has allowed an improvement in the physiological relevance of responses to stimuli. Furthermore, brain organoids and neurons cultured in microfluidic systems are the latest frontiers for in vitro reproduction of rhythmic electrical signals. In this review, the combination of these in vitro experimental approaches is proposed as suitable for a more direct investigation on the common mechanisms and neurophysiological substrates underlying brain waves and circadian oscillations, and useful to evaluate the effects of “oscillotherapeutic” drugs for personalized neuromedicine
Circadian and dopaminergic influence on chlorogenic acid intestinal permeability
No full textChlorogenic acid (CGA) is a natural polyphenol potentially health promoting along the gut-brain axis, even if limited by poor oral bioavailability. As components of therapeutic drugs or functional food, polyphenols can influence each other their absorption from the gut according to circadian rhythms.
Therefore, we have evaluated, via HPLC-UV analysis, how the permeability of CGA across IEC-6 cell monolayers, as a model of intestinal barrier, is influenced by the presence of arbutin, gallic, caffeic and ferulic acids and by circadian cycles entrainment by horse serum shock. Moreover, dopaminergic neuronal influence on CGA intestinal permeability was investigated by co-culture with rat pheochromocytoma PC12 cell line mimicking dopaminergic component of enteric nervous system (ENS).
Our results indicate the presence of a circadian-dependent active efflux for CGA permeation across IEC-6 monolayers, suggesting its higher bioavailability in the evening rather than in the morning. Among the natural polyphenols tested, only gallic acid was able to influence the CGA permeation, causing its reduction. Finally, (60 mM KCl)-evoked dopamine release from PC12 cells induced a significant CGA permeation increase across IEC-6 monolayers, probably by downregulation of efflux transporters expression/activity. Dopamine ENS-evoked may therefore enhance the CGA oral bioavailability dependence on circadian rhythms.
Although this is a preliminary study in this field, the results obtained allow us to suggest that the absorption of CGA from an oral administration of a food supplement is not influenced by arbutin, caffeic acid and ferulic acid, whereas it can be enhanced in the absence of gallic acid and by evening intake
Richardson, Barbauld, and the construction of an early modern fan club
No full textMPhilMuch has been written about the life and long works of the eighteenth century epistolary novelist, Samuel Richardson, but the prospect of his position as the first celebrity novelist – responsible for courting his own fame as well as initiating his own fan club – has largely been ignored. The body of manuscripts housed at the National Art Library in the Victoria and Albert Museum in London provides the modern scholar with evidence of the skeletal beginnings of an early fan club. This thesis aims to show how these manuscripts were turned into a saleable commodity by the publisher and entrepreneur Richard Phillips, while under the guiding hand of another, slightly later, literary celebrity, Anna Laetitia Barbauld. In order to restore Richardson’s reputation amongst a new nineteenth century audience, Barbauld was required to construct her own idea of him as an eighteenth century celebrity author, and in doing so the insecurities of a self-professed, apparently diffident man, are revealed. Barbauld’s capacious, but heavily edited selection of letters is analyzed in this thesis, providing ample evidence that Richardson’s correspondents were more than just eager letter writers. By using Barbauld’s biography of Richardson this thesis aims to show how she manipulates the genre of life writing in her construction of him.
This thesis offers an alternative reading of how the Richardson manuscripts are viewed, redefining them as not simply a collection of letters, but as a collective entity, deliberately selected and archived as evidence of an early modern fan club, and its celebrity managing director
Selection of work by Anna Gerber
No full textVarious journals and magazines Anna Gerber has contributed to. Anna Gerber is a graphic designer and writer based in London.
She is the author and designer of All Messed Up: Unpredictable Graphics (Laurence King, 2004) and co-editor and co-designer
of Influences: A Lexicon of Contemporary Graphic Design (Die Gestalten Verlag, 2006) with Anja Lutz. She writes regularily for magazines such as Print, Eye, Creative Review, Varoom and Idea Magazine and her work has also been published in shift!, dot dot dot and +rosebud.
She teaches at the London College of Communication on the BA Graphic Design and MA Design Writing Criticism programmes. She has also held workshops and lectures across the U.K. (including Tate Modern and the V&A Museum), as well as in India, the U.S., Australia and Malaysia.
Anna Gerber is currently engaged in research and developing projects relating to sustainability and how it applies to graphic
design as well as exploring contemporary graphic design in India
Author and Lecturer Anna Bird Stewart will Speak at the University of Dayton
No full textNews release announcing the visitation and speech of author and lecturer Anna Bird Stewart to the University of Dayton
Operatori del processo edilizio
No full textLemma che descrive i diversi attori del processo edilizio, con particolare attenzione al processo edilizio pubblico - ISBN:ISSN 2284-00IX - visibile su: Wikitecnica.com/author/giovenale-anna-mari
Processo edilizio
No full textLemma che descrive e reinterpreta, rispetto alla letteratura scientifica, il concetto di processo edilizio, definendone l'evoluzione nel tempo ISBN:ISSN 2284-00IX - Visibile su: wikitecnica.com/author/giovenale-anna-mari
Metaprogettazione
No full textLemma che descrive il concetto di metaprogettazione e pone in risalto l'importanza nell'architettura contemporanea dello strumento "metaprogetto" - ISBN:ISSN 2284-00IX - visibile su: Wikitecnica.com/author/giovenale-anna-mari
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