11 research outputs found
ChemInform Abstract: Isoquinolinium Bromochromate: New, Efficient and Stable Reagent for Oxidation of Aromatic Amines and Phenols.
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Pyridinium Bromochromate: A New and Efficient Reagent for Bromination of Hydroxy Aromatics.
No full textA green synthesis of isoquinolines using Ru(II)/PEG-400 as homogeneous recyclable catalyst via C-H/N-N bond activation
Get PDF842-849A novel and green synthesis of 1-phenyl isoquinoline derivatives has been developed by using Ru(II)/PEG-400 as homogeneous recyclable catalyst via C-H/N-N bond activation via C-H/N-N functionalization of 1-(diphenylmethylene) hydrazine and aryl substituted acetylenes. In order to realize the proposed protocol, Cu(OAc)2 and AgSbF6 are used as oxidant and additive respectively in PEG-400 biodegradable solvent. This protocol has a simple extraction procedure, uses biodegradable solvent, affords high atom economy, employs a reusable catalytic system, provides wide substrate scope with high yield of product, for the synthesis of isoquinoline derivatives
ChemInform Abstract: Isoquinolinium Bromochromate: An Efficient and Stable Reagent for Bromination of Hydroxylated Aromatic Compounds and Oxidation of Alcohols
No full textDesign and Synthesis of Novel 1,2,3-triazolyl-pyrimidinone Hybrids as Potential Anti-HIV-1 NNRT Inhibitors
No full textDesign, Synthesis and Docking Studies of Novel 1, 2, 3-Triazolyl Phenylthiazole Analogs as Potent Anti-HIV-1 NNRT Inhibitors
No full textJuvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice
No full textBackground: The anthracycline doxorubicin (DOX) is an effective chemotherapeutic agent used to treat pediatric cancers, but is associated with cardiotoxicity which can manifest many years after the initial exposure. To date, very little is known about the mechanism of this late onset cardiotoxicity.
Methods and Results: To understand this problem, we developed a pediatric model of late onset DOX-induced cardiotoxicity, where juvenile mice were exposed to DOX, using a cumulative dose that did not induce acute cardiotoxicity. These mice developed normally and had no obvious cardiac abnormalities as adults. However, evaluation of the vasculature revealed that juvenile DOX exposure impaired vascular development resulting in abnormal vascular architecture in the hearts with less branching and decreased capillary density. Both physiological and pathological stress induced late onset cardiotoxicity in the adult DOX mice. Moreover, adult mice subjected to myocardial infarction (MI) developed rapid heart failure which correlated with a failure to increase capillary density in the injured area. Progenitor cells participate in regeneration and blood vessel formation after an MI, but DOX mice had fewer progenitor cells in the infarct border zone. Interestingly, DOX treatment reduced proliferation and differentiation of the progenitor cells into cells of cardiac lineages.
Conclusions: Our data suggest that anthracycline treatment impairs vascular development as well as progenitor cell function in the young heart, resulting in an adult heart that is more susceptible to stress.Journal ArticleFinal article publishe
A green synthesis of isoquinolines using Ru(II)/PEG-400 as homogeneous recyclable catalyst via C-H/N-N bond activation
Get PDFA novel and green synthesis of 1-phenyl isoquinoline derivatives has been developed by using Ru(II)/PEG-400 as homogeneous recyclable catalyst via C-H/N-N bond activation via C-H/N-N functionalization of 1-(diphenylmethylene) hydrazine and aryl substituted acetylenes. In order to realize the proposed protocol, Cu(OAc)2 and AgSbF6 are used as oxidant and additive respectively in PEG-400 biodegradable solvent. This protocol has a simple extraction procedure, uses biodegradable solvent, affords high atom economy, employs a reusable catalytic system, provides wide substrate scope with high yield of product, for the synthesis of isoquinoline derivatives
Reliable state retention-based embedded processors through monitoring and recovery
No full textState retention power gating and voltage-scaled state retention are two effective design techniques, commonly employed in embedded processors, for reducing idle circuit leakage power. This paper presents a methodology for improving the reliability of embedded processors in the presence of power supply noise and soft errors. A key feature of the method is low cost, which is achieved through reuse of the scan chain for state monitoring, and it is effective because it can correct single and multiple bit errors through hardware and software respectively. To validate the methodology, ARM Cortex-M0 embedded microprocessor (provided by our industrial project partner) is implemented in FPGA and further synthesized using 65-nm technology to quantify the cost in terms of area, latency and energy. It is shown that the proposed methodology has a small area overhead (8.6%) with less than 4% worst-case increase in critical path and is capable of detecting and correcting both single bit and multi bit errors for a wide range of fault rates
