26 research outputs found
Induced sputum versus broncho-alveolar lavage for pathogen surveillance in young cystic fibrosis patients: Low specificity is not necessarily a bad thing
No full textCorrection: Implementing digital respiratory technologies for people with respiratory conditions:A protocol for a scoping review ( vol 19, e0314914, 2024)
No full textThere are errors in the author affiliations. The correct affiliations are as follows: Chi Yan Hui 1, Kathleena Condon 2, Shailesh Kolekar 3, Nicola Roberts 4, Katherina Bernadette Sreter 5, Sami O. Simons 6, Carlos Figueiredo 7, Zoe McKeough 8, Hani Salim 9, Aleksandra Gawlik-Lipinski 10, Apolline Gonsard 11, Ayşe Önal Aral 12, Anna Vanoverschelde 13, Matthew Armstrong 14, Dario Kohlbrenner 15, Cátia Paixão 16, Patrick Stafler 17, Efthymia Papadopoulou 18, Adrian Paul Rabe 19, Milan Mohammad 20, Izolde Bouloukaki 21, Shirley Quach 22, Malek Chaabouni 23, Georgios Kaltsakas 24, Kate Loveys 25, Tonje Reier-Nilsen 26, Anthony Paulo Sunjaya 27, Paul Robinson 2, Hilary Pinnock 1, Amy Hai Yan Chan 28 1 Allergy and Respiratory Research Group, Usher Institute, The University of Edinburgh, Edinburgh, United Kingdom, 2 Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia, 3 Department of Respiratory Medicine, Zealand University Roskilde Hospital, Institute of Clinical Medicine Copenhagen University, Copenhagen, Denmark, 4 School of Health and Social Care, Edinburgh Napier University, Edinburgh, United Kingdom, 5 Department of Pulmonology, University Hospital Centre "Sestre Milosrdnice", Zagreb, Croatia, 6 Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, Netherlands, 7 Department of Pulmonology, Hospital de Santa Marta, Lisbon, Portugal, 8 Discipline of Physiotherapy, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia, 9 Department of Family Medicine, Faculty of Medicine & Health Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia, 10 Department of Respiratory Medicine, University of Leicester, Leicester, United Kingdom, 11 Department of Pediatric Pulmonology and Allergology, University Hospital Necker-Enfants Malades, APHP, Paris, France, 12 Pulmonary Diseases Clinic, Ankara Go¨lbaşı State Hospital, Ankara, Turkey, 13 Hospital Outbreak Support Team (HOST), H.uni network, Brussels, Belgium, 14 Department of Rehabilitation & Sports Science, Bournemouth University, Bournemouth, England, United Kingdom, 15 Faculty of Medicine, University of Zurich, Zurich, Switzerland, 16 Respiratory Research and Rehabilitation Laboratory (Lab3R), School of Health Sciences (ESSUA), University of Aveiro, Aveiro, Portugal, 17 Pulmonary Institute, Schneider Children’s Medical Center of Israel, Petach Tikvah, Israel, 18 Pulmonology Department, General Hospital of Thessaloniki, Thessaloniki, Greece, 19 Department of Primary Care and Public Health, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom, 20 Centre for Physical Activity Research, Copenhagen University Hospital, Copenhagen, Denmark, 21 Department of Social Medicine, School of Medicine, University of Crete, Crete, Greece, 22 School of Rehabilitation Sciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada, 23 Department of Internal Medicine II—Pulmonology Section, Asklepios Klinik Altona, Hamburg, Germany, 24 Centre for Human and Applied Physiological Sciences (CHAPS), King’s College London, London, United Kingdom, 25 Department of Paediatrics: Child and Youth Health, The University of Auckland School of Medicine, Grafton, Auckland, New Zealand, 26 The Norwegian Sports Medicine Centre, Oslo, Norway, 27 Respiratory Division, The George Institute for Global Health, Sydney, Australia, 28 School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.</p
Ethnic Differences in Fraction of Exhaled Nitric Oxide and Lung Function in Healthy Young Children
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Validation of a computerized scoring system for foreign body aspiration: An observational study
No full textLactose-Containing Dry-Powder Inhalers for Patients with Cow’s Milk Protein Allergy—The Conundrum; A National Survey of Pediatric Pulmonologists and Allergologists
No full textIntroduction: Several dry-powder inhalers (DPIs) contain lactose which may be contaminated with milk proteins. Confusion exists pertaining to DPI use in patients with cow’s milk protein allergy (CMPA). Methods: A computerized survey sent via e-mail to pediatric pulmonologists and allergologists. Results: A total of 77 out of 232 (33.2%) doctors replied, of whom 80.5% were pediatric pulmonologists. A total of 69 of 77 (89.6%) were specialists, 37.6% with more than 15 years of experience. The most commonly used DPIs were formoterol + budesonide and vilanterol + fluticasone. A total of 62 out of 77 (80.5%) responders knew these DPIs contained lactose. A total of 35 out of 77 (45.5%) doctors who replied did not know that DPI leaflets list CMPA as a contra-indication to DPI administration. Of these, 4 (11.4%) stated that they would instruct patients with CMPA to stop DPIs, and 7 (20%) would avoid recommending DPIs. A total of 42 out of 77 (54.5%) responders were aware of this warning, yet 13 of these 42 (30.9%) continued to recommend lactose-containing DPIs without hesitation and 18 of these 42 (42.8%) responders prescribed DPIs but considered allergy severity. Conclusions: Almost half of certified, experienced pediatric pulmonologists and allergologists were unaware of the warning to administer DPIs to patients with CMPA. Most doctors who do know of this warning still continue to prescribe these DPIs
Feasibility of multiple breath washout measurements in infants with bronchiolitis: A pilot study
No full textIncreasing nontuberculous mycobacteria infection in cystic fibrosis
No full textAbstractBackgroundNontuberculous mycobacteria (NTM) are emerging infections in the CF population.AimsTo assess NTM infection prevalence and associated features in our CF clinic population.MethodsPatient records, 2002–2011, were reviewed for NTM infection. FEV1, pancreatic function, sputum microbiology, and serum cytokines were compared in patients with and without NTM infection.ResultsIncidence rate of NTM infection increased from 0 in 2002 to 8.7% in 2011 (p<0.001). NTM infection prevalence increased 3-fold from 5% (4/79) in 2003 to 14.5% (16/110) in 2011 (p=0.05). Prevalence of chronic NTM lung disease has decreased somewhat since a peak in 2009, with institution of aggressive triple therapy. Of NTM-infected compared to uninfected patients, 88.2% vs. 60.3% had a known ‘severe’ CFTR genotype (p=0.04), 88.2% vs. 58.9% were pancreatic insufficient (p=0.02); 70.6% vs. 43.8% had chronic Pseudomonas aeruginosa (p=0.06); 75% vs. 32% had Aspergillus infection (p=0.007) and 23.5% vs 2.7% had allergic bronchopulmonary aspergillosis (p=0.01). Patients infected with Mycobacterium abscessus had increased TGF-β, TNF-α, IL-1β, IL-2, IL-4 and IL-5 levels (p<0.05). There was no difference in cytokine levels for all NTM infected compared to uninfected patients. M. abscessus comprised 46% of all NTM infections. Comparing M. abscessus versus other NTM, duration was 10.5 (1–118) months versus 1 (1–70) month, median (range) (p=0.004); lung disease occurred in 69% versus 17% (p=0.0004), with sputum conversion in 4/11 versus 5/6, respectively (NS).ConclusionsNTM incidence and prevalence have increased dramatically in our CF clinic, associated with a severe CF genotype and phenotype. M. abscessus, the most prevalent NTM, caused prolonged infection despite therapy. There has been some decrease in the prevalence of NTM lung disease since 2009
