4,732 research outputs found
Newman Noggs and Patrick Page
No full textDouglas H. Baker (Newman Noggs) sits at a table looking at his pocket watch, while Patrick Page (Ralph Nickleby) stands next to him talking during a performance of "The Life and Adventures of Nicholas Nickelby"
Investigation of the sequence specific DNA/protein interactions of the ECORV restriction enzyme
No full textThe EcoRV restriction enzyme from Escherichia coli recognises the sequence GATATC on double stranded DNA and cuts between the central residues with very high specificity. The self complementary dodecadeoxynucleotide dGACGATATCGTC which contains the EcoRV recognition site (underlined) is also a substrate for the endonuclease. The thesis describes the synthesis of fourteen dodecamers of the above parent sequence in which the functional groups of the central ATAT residues accessible to the protein via the DNA major and minor grooves have been systematically and sequentially deleted. Conservative contact deletions were achieved by the substitution of the two deoxyadenosine residues in turn with the base analogues purine deoxyriboside (dP), 7-deazadeoxyadenosine (d7CA) and 3-deazadeoxyadenosine (d3CA). Similarly the two thymidine residues were substituted with deoxyuridine (dU), 5-methyl-2-pyrimidonone deoxyriboside (d4HT),4-thiothymidine (d4ST) and 2-thiothymidine (d2ST). To obtain the complete set of analogues, efficient synthetic routes for the formation of derivatives of d4HT, d4ST and d2ST suitable for oligodeoxynucleotide synthesis using the cyanoethyl phosphoramidite approach are described (also see Connolly & Newman (1989) Nucleic Acids Research 17, 4957-4974). The work represents the first time that d4ST and d2ST have been incorporated into synthetic oligodeoxynucleotides. All the analogue substituted dodecamers were obtained in a pure state and characterisation by deoxynucleoside composition analysis, hyperchromicity, melting temperature and circular dichroism spectroscopy showed them to be of the expected composition and that they form stable duplexes of the B-DNA conformation. The only discrepancy is the circular dichroism spectra of the d2ST dodecamers, which are not typical of B-DNA. Ten of the fourteen analogue substituted dodecamers were determined to be substrates for the EcoRV endonuclease. The kinetics of cleavage of these substrate dodecamers were analysed along with the parent dodecamer by assays utilising HPLC and gel separation methods, the latter method using 5'- phosphorylated substrates. It is found that 1: 5'-phosphorylation further decreases the cleavage rate of the most poorly cleaved analogue dodecamers, 2: the Mg2+ cofactor affinities for the parent dodecamer and two poorly cleaved substrates are similar, 3: the specificity of cleavage of the dodecamers (as determined by the kcal/KmM ratio) is 1000-fold lower than for the cleavage of plasmid DNA. Only two of the functional groups within the ATAT core of the GATATC site are not involved in recognition interactions (the 2-keto oxygen of the first thymidine and the N7 atom of the second deoxyadenosine). Apparent binding energy values for the deletion of the other functional groups are in the range of -4.8 to -6.7kJmol-1 for the hydrogen bond donors/acceptors and -7.8 and -9.4kJmol-1 for the two thymidine methyl groups. These values correspond to expected strengths of hydrogen bonds and Van der Waals contacts resepctively. It is concluded that EcoRV endonuclease makes sequence specific interactions to the majority of the functional groups of the ATAT core of GATATC both via the major and minor groove, many more than required for unambiguous discrimination of cognate and non-cognate sites.</p
Comprehensive Bibliography of Chadic and Hausa Linguistics, Third Edition
No full textThe Comprehensive Bibliography of Chadic and Hausa Linguistics is an updated, expanded, and corrected edition of the print book published some twenty years ago by Rüdiger Köppe Verlag (Newman 1996). The outpouring of new publications on Chadic and Hausa in the ensuing years created the need for an updated bibliography. The first edition of this online bibliography was published in 2012 at Bayreuth University, the second edition in 2013 at Indiana University (http://hdl.handle.net/2022/16600), and the current third edition in 2015, also at Indiana University. This comprehensive bibliography covers all works written on Chadic and Hausa languages and linguistics dating from 1790 to the present. In addition to published books and articles, the bibliography includes unpublished Ph.D. dissertations and master's theses. The bibliography is international in scope and covers works regardless of the language in which they were written. For example, there are close to a hundred works written in Hausa. Titles of works in languages other than English, French, or German are accompanied by English translations. Russian titles in Cyrillic script are transliterated into Roman script. Book reviews are listed under the entry for the book being reviewed. A new feature of this 3rd edition is the addition of a Book Review Author Index, which indicates all the books that any individual has reviewed. Finally, the bibliography contains a section consisting of obituaries, (auto-) biographical essays, and related works on major scholars, now deceased, who have contributed significantly to Chadic or Hausa linguistics
Towards the tumble resistant microlight
No full textThe tumble mode is a pitching departure from controlled flight which leads to a pitch autorotation that is generally unrecoverable – resulting in vertical ground impact, usually preceded by in-flight breakup (the mechanism for which, surprisingly, can sometimes prevent loss of life). This was identified in work led by the British Microlight Aircraft Association beginning in 1997 as a response to a number of fatal accidents in Rogallo winged microlight aeroplanes, although the tumble is also known to occur to hang-gliders. This paper explains how this class of aeroplane is controlled, and how it has been found that they can enter the tumble mode. The mechanism by which the tumble can be entered is described. This has led to work showing how flight testing can be used to establish and demonstrate resistance to tumble entry – particularly important with increasing number of very high performance flexwings. These flight tests will be explained, together with the significance of the results. Recent accident investigation work has also shown a new mechanism of tumble entry, through partial failure of the A-frame structure and the pitch-trimmer mechanism. Also described is a possible relevance to well known historical accidents to flying wing aeroplanes– specifically the YB-49 and dH-108, and discovered data on the characteristics of the BKB-1flying wing glider; are also described
Interview with Marvin Newman
No full textProf. Marvin Newman grew up in Chicago, Illinois, and South Florida. He received his bachelor’s degree from Northwestern University in 1956, then continued his studies at the University’s law school, where he earned his L.L.B. and J.D. degrees, graduating magna cum laude.
With his wife and newborn daughter, Newman moved to Orlando in 1960 and began practicing as an attorney. He joined Rollins in 1961 as an adjunct lecturer in Business Law. His passion for the subject was evident, and within a year, he was teaching classes Monday through Thursday and sometimes on the weekends, while continuing to practice law and devote time to his growing family (the Newmans eventually had four daughters). In 1972 he became a tenured professor in the College of Arts and Sciences.
A popular and dedicated teacher, Prof. Newman received numerous awards over the course of his career, including the Hugh and Jeannette McKean Grant, The Outstanding Professor Award from the Crummer Graduate School of Business, The Rollins Decoration of Honor, and the College’s Distinguished Teaching Award. He introduced a total of 10 courses to the Rollins curriculum, but the one that is dearest to him is “Death and Dying.” This class was immediately popular with students and led to Prof. Newman becoming an internationally recognized scholar on ethical and legal issues related to the terminally ill. He is the author of numerous publications and co-author of several books on this topic, including To Die or Not to Die and Perspectives on Death and Dying.
Prof. Newman retired from Rollins in 2011. Looking back on his teaching career, he said, “I feel that it’s the memories my students will have of me that will count more than the assets that I leave. So it’s been wonderful.
Mismatch, rematch, and investment
No full textThis paper studies rigidities in sharing joint payoffs (non-transferability) as a source of excessive segregation in labor or education markets. The resulting distortions in ex-ante investments, such as education acquisition, link such mismatches to the possibility of simultaneous under-investment by the underprivileged and over-investment by the privileged. This creates an economic rationale for rematch policies like affirmative action, which have to be evaluated in terms of both incentives and the assignment quality. We compare a number of such policies that have empirical counterparts. Our results indicate that some of these policies can be beneficial on both equity and efficiency grounds
Papers of Patrick Morgan
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/65585Drama notes, labelled 'English Literature, Modern Drama. P.Morgan Newman College.' Misc. notes and essay, interleaved programmes. cuttings, roneoed copy of script of Duerrenmatt's 'The Old Lady Pays a Visit'; some of the material dated 1963.113582
Acquisition: [1979.0075] "Papers of Patrick Morgan
Lesléa Newman, 32nd Annual ODU Literary Festival
No full textLesléa Newman is the author of 55 books for adults and children, including the short story collection, A Letter to Harvey Milk, the poetry collection, Nobody\u27s Mother, and the children\u27s classic, Heather Has Two Mommies. Her literary awards include creative writing fellowships from the National Endowment for the Arts and the Massachusetts Artists Foundation, the James Baldwin Award for Cultural Achievement, and a Parents\u27 Choice Silver Medal. She is the Poet Laureate of Northampton, Massachusetts
Reflections of a Jewish, Lesbian Author
No full textIn this essay, Jewish lesbian author Leslea Newman speaks of the importance of finding one's own identity reflected in works of literature, citing examples of her own work, and recommending the writings of other Jewish lesbian authors of merit
Comprehensive Bibliography of Chadic and Hausa Linguistics, Fourth Edition
No full textThe Comprehensive Bibliography of Chadic and Hausa Linguistics, 4th edition, includes works written on Chadic and Hausa languages and linguistics dating from 1790 to the present. The bibliography contains published books and articles as well as unpublished Ph.D. dissertations and master’s theses. The bibliography is international in scope and covers works regardless of the language in which they were written. For example, there are approximately 500 entries written in French, 300 in German, 125 in Hausa, and 100 in Russian. Titles of works in languages other than English, French, or German are accompanied by English translations. Russian titles in Cyrillic script are transliterated into Roman script. Book reviews are listed under the entry for the book being reviewed. In addition, there is Book Review Author Index that indicates all the books that any individual has reviewed. Finally, the bibliography contains a small section consisting of obituaries, (auto-)biographical essays, and related works on major scholars, now deceased, who have contributed significantly to Chadic and Hausa linguistics. The first edition of this online bibliography was published in 2012 at Bayreuth University. The second edition (2013) and the third edition (2015) were published at Indiana University (http://hdl.handle.net/2022/16600). This is an open access work fully and freely available for education, research, and other scholarly purposes
- …
