306 research outputs found
Centralizer-like Subgroups Associated with the -Engel Words Inside of Direct Product Groups
No full textThis research provides a characterization of centralizer-like subgroups associated with the -Engel word in a direct product of groups. Specifically, properties of the set of right -Engel elements inside of direct products are explored. A proof is given to demonstrate the equivalence between the set of right -Engel elements of a direct product of two groups and a direct product of the set of right -Engel elements of each direct factor. This work was inspired by the study of centralizer-like subgroups in paper written by Luise-Charlotte Kappe and Patrick Ratchford. We present additional questions explored during this project, and we propose future research possibilities
Contracting arrangements in agribusiness procurement practices in South Africa
No full textContracting arrangements in agribusiness procurement practices in South AfricaProcurement, contracting, agro-processing,
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Liquid-liquid Phase Separation of the Nucleocapsid of SARS-CoV-2
No full textThe nucleocapsid of SARS-CoV-2 is critical for viral genome packaging through binding to viral genomic RNA. Liquid-liquid phase separation, or LLPS, is the formation of microscopic, rapidly reversible, liquid-like immiscible droplets. There is increasing scientific evidence that LLPS underlies the formation of membraneless compartments within cells and that this process has a significant role in human health and the development of disease. Prior research suggests that the nucleocapsid of SARS-CoV-2 undergoes LLPS with different sequences of viral RNA and that this mechanism may facilitate viral assembly. In this study, the full-length nucleocapsid (FL-N), the C- and N-terminal domain (CTD and NTD), and Linker, in addition to segments of viral genomic RNA, were grown, purified, and fluorescently labeled. Through microscopic analysis, droplet formation was observed for FL-N and CTD with all RNA constructs tested, with increased droplet formation after overnight incubation at 37° C, suggesting that RNA sequence specificity does not drive phase separation under these conditions and that the dimerization domain assists in LLPS. The WT Linker was observed to form spherical condensates after shorter incubation times that would shift to aggregates after overnight incubation. Phosphorylation of S188 was observed to have decreased droplet formation at lower concentrations of FL-N.Key Words: Liquid-liquid phase separation, SARS-CoV-2, nucleocapsid, virus, pandemic, protein, RNA
Overview of Cherenkov Telescope on-board EUSO-SPB2 for the Detection of Very-High-Energy Neutrinos
No full textWe present the status of the development of a Cherenkov telescope to be flown on a long-duration balloon flight, the Extreme Universe Space Observatory Super Pressure Balloon 2 (EUSO-SPB2). EUSO-SPB2 is an approved NASA balloon mission that is planned to fly in 2023 and is a precursor of the Probe of Extreme Multi-Messenger Astrophysics (POEMMA), a candidate for an Astrophysics probe-class mission. The purpose of the Cherenkov telescope on-board EUSOSPB2 is to classify known and unknown sources of backgrounds for future space-based neutrino detectors. Furthermore, we will use the Earth-skimming technique to search for Very-High-Energy (VHE) tau neutrinos below the limb (E > 10 PeV) and observe air showers from cosmic rays above the limb. The 0.785 m^2 Cherenkov telescope is equipped with a 512-pixel SiPM camera covering a 12.8° x 6.4° (Horizontal x Vertical) field of view. The camera signals are digitized with a 100 MS/s readout system. In this paper, we discuss the status of the telescope development, the camera integration, and simulation studies of the camera response
Letter re: Amon Carter, Jr.
No full textLetter from Pat to Katrine Deakins, secretary to Amon Carter regarding Amon Carter, Jr. as a prisoner of war.U.S. Navy Yard Portsmouth, N. H. September 28, 1944 Dear Katrine, I know it seems incredible, but I am still in the same old place. I have thought many times that my tour of duty in these United States would end, and I would go to sea but I guess my number hasn't come up yet. How is Amon getting along? I receive one of his post-cards about every month or so, but don't say very much. He has been over there so very long, I know he must be very tired of that P.O.W. routine even though he doesn't say much about it. Maxine and I were in New York for a couple days around the 16th of this month. We met her mother and father there and they came up to Portsmouth with us for a visit. I phoned Ruth , but did not have much luck. I also asked about Mr. Carter at the Stork Club and also at the Waldorf. It appears that he had been there about 10 days before. I have finally recovered from my appendectomy and am now able to do all the things I used to. Instead of gas or other, they gave me a spinal and I thnk they must have injured the nerves bcause it took about 8 weeks to get over it. I know this request may be a little premature, but when Amon comes back and if he returns to New York I would appreciate it very much if you would let me know. We are only about 350 miles from there and I would sure like to see him. I know that if I don't see him then it may be a year or more before there is another opportunity. Please give my very best regards to Mr. Carter and Ruth. I was so sorry that I was unable to see or at least phone them when I was in N. Y. Very truly yours Pa
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A Nascent Helix in Dynein Intermediate Chain is Essential for Regulating Dynein/Dynactin Complexes
No full textCytoplasmic dynein is a motor protein complex found in eukaryotes that is essential to many cellular processes. With dynein being involved in mitosis, axonal transport and organelle transport, disruption of dynein function can lead to neurodegeneration and other diseases. The main function of dynein is transportation of cargo through the attachment of a cofactor or regulatory protein, like dynactin. Many of dynein’s functions are regulated by binding of dynein intermediate chain (IC) to dynactin p150. This interaction involves a single alpha helix (SAH) at the N-terminus of IC and the coiled-coil region (CC1B) on p150. Previous studies in the Barbar lab have shown that there is a secondary helix (H2) downstream of SAH that is structurally varied among the species of IC. This study looks closely at IC from Chaetomium thermophilum (CT), and experiments reveal that it has a weak H2 and substantially stronger binding to p150. The data from this study describe the role of H2 in binding and is the first to show direct interactions between H2 and p150. A combination of results from isothermal titration calorimetry (ITC), circular dichroism (CD) and nuclear magnetic resonance (NMR) are used to map the binding site of CT IC on p150.
Key Words: Cytoplasmic dynein, dynein intermediate chain, dynactin p150, secondary helix, intermediate chain and p150 bindin
Letter re: Amon Carter, Jr.
No full textLetter from Pat to Katrine Deakins, secretary to Amon Carter regarding Amon Carter, Jr. as a prisoner of war.November 22, 1943 US. Navy yard Portsmouth, N. H. Dear Katrine, It has been so long since I have heard any news about Amon, and would give any thing to know that he is all right and feeling fine. I wonder if you would be kind enough to write me a short letter just to let me know the latest information that you have received. I have been listening to the radio and have heard various German prisoners of war who have been returned, and most of them had been there for a much shorter time than Amon. It would be possible for Amon to be back and I would know nothing about it. I guess you know by now, but just in case you don't, I was married the 3rd of November in Austin. I think you and Mr. Carter know my wife, Maxine Robison, because she has been to Ft. Worth a few times with me, and has met both you and Mr. Carter. It was a very nice wedding, but would have been absolutely perfect if Amon would have been there. I thought about him so much, and every one wanted to know if I had any news about him. I had a ten day leave, and after being married in Austin, we went to New York where we saw the army - Notre Dame game and had a wonderful time. I reported back on November 11th and am now living in a small house about ten miles from the Navy Yard, because the living quarters that are nearer are more expensive and are not as good. Maxine is really a swell girl and we are very happy up here. I am still working with, and testing submarines, and the work is very interesting. I will probably be up here until next spring and then go out. How is Mr. Carter feeling? I wish you would give him my very best regards. He has always been so nice to me, and I have appreciated it so much. Very truly yours, Pa
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Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2
No full textDysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play a crucial role in the development and maintenance of the transverse-tubule system, a specialized structure in muscle cells involved in excitation-contraction coupling and calcium homeostasis. Dysferlin requires the presence of the signaling phospholipid phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) to form these membranous structures. Dysferlin is also implicated in sarcolemmal wound repair, in response to elevated cytoplasmic Ca2+ dysferlin coordinates membrane repair machinery to assemble underlying vesicles into a membranous patch to seal the breach. Both dysferlin and PI(4,5)P2 accumulate at these lesions. Out of dysferlin’s seven C2 domains, only the N-terminal C2 domain is known to bind PI(4,5)P2, however the exact binding site, affinity, and calcium dependence of this interaction is yet unknown. In this work, nuclear magnetic resonance spectroscopy and complementary techniques were employed to locate the binding site of the PI(4,5)P2 headgroup on dysferlin C2A, and to provide a mechanism by which Ca2+ regulates PI(4,5)P2 binding
What Drives Racial Segregation? New Evidence Using Census Microdata
No full textThis paper sheds new light on the forces that drive residential segregation on the basis of race, assessing the extent to which across-race differences in other household characteristics can explain a significant portion of observed racial segregation. The central contribution of the analysis is to provide a transparent new measurement framework for understanding segregation patterns. This framework allows researchers to characterize patterns of segregation, to decompose them in meaningful ways, and to carry out partial equilibrium counterfactuals that illuminate the contributions of a variety of non-race characteristics in driving segregation. We illustrate our approach using restricted micro-Census data from the San Francisco Bay Area that provide a rich joint distribution of household and neighborhood characteristics not previously available to the research community. In contrast to findings in the prior literature, our analysis indicates that individual household characteristics can explain a considerable fraction of segregation by race, explaining almost 95% of segregation for Hispanic, over 50% for Asian, and 30% for White and Black households.Residential Segregation, Racial Segregation, Sorting, Housing Markets
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