1,189 research outputs found
Using a simplified Bishop score to predict vaginal delivery
No full textLetter to the EditorParvin Tajik, Patrick M. Bossuyt, Ben Willem Mo
Non-invasive tests for the diagnosis of endometriosis
No full textExtent: 37p.Vicki Nisenblat, Cindy Farquhar, Ali Akoum, Ian Fraser, Patrick MM Bossuyt and M Louise Hul
Chlamydia antibody titer testing versus hysterosalpingography for detection of tubal pathology in subfertile women
No full textSjors F Coppus, M Chandra, A Coomarasamy, Neil Johnson, Fulco Van der Veen, Patrick MM Bossuyt, Ben Willem J Mo
"Patient-centered fertility treatment": what is required?
No full textCorrected by: Erratum: Patient-centered fertility treatment: What is required? (in Fertil Steril (2014) 102(5):1499). There were errors in the listing of the authors' names in the print version of the article, “Patient-centered fertility treatment: what is required?” (Fertil Steril 2014;101(4):924–6). The authors should be listed as Eline Anke Dancet, Thomas Maria D'Hooghe, Fulco van der Veen, Patrick Bossuyt, Walter Sermeus, Ben-Willem Mol, and Sjoerd Repping.Eline Anke Dancet, Thomas Maria D'Hooghe, Fulco van der Veen, Patrick Bossuyt, Walter Sermeus, Ben-Willem Mol, and Sjoerd Reppin
Interpreting results in Clinical Research (Overview of effects measures and measures of precision for clinicians and researchers)
No full textReproducibility and reliability of repeated semen analyses in male partners of subfertile couples
No full textPresented in part at the 65th Annual Meeting of the American Society for Reproductive Medicine, Atlanta, Georgia, October 17–21, 2009.Abstract not availableEsther Leushuis, Jan Willem van der Steeg, Pieternel Steures, Sjoerd Repping, Patrick M.M. Bossuyt, Marinus A. Blankenstein, Ben Willem J. Mol, Fulco van der Veen, and Peter G.A. Hompe
A potential for seamless designs in diagnostic research could be identified
No full textBACKGROUND AND OBJECTIVE: New diagnostic tests to identify a well-established disease state must undergo a series of scientific studies from test construction to finally demonstrating a societal impact. Traditionally, these studies are performed with substantial time gaps in between, resulting in a long time period from the initial idea to roll out in clinical practice including reimbursement. Seamless designs allowing us to combine a sequence of studies in one protocol may hence accelerate this process. Currently, a systematic investigation of the potential of seamless designs in diagnostic research is lacking.METHODS: We identify major study types in diagnostic research and their basic characteristics with respect to the application of seamless designs. This information is used to identify major hurdles and opportunities for seamless designs.RESULTS: The following major study types were identified: Variable construction studies, cut point finding studies, variable value studies, single-arm accuracy studies, comparative accuracy studies, change-in-management studies, observational discordant pair studies, randomized discordant pair studies, and randomized diagnostic studies. The following characteristics were identified: Type of recruitment (case-control vs. population-based), application of a reference standard, inclusion of a comparator, paired or unpaired application of a comparator, assessment of patient-relevant outcomes, and possibility for blinding of test results. Two basic hurdles could be identified: 1) Accuracy studies are hard to combine with postaccuracy studies in a seamless design for the following reasons. First, because the former are required to justify the latter and application of a reference test in outcome studies may be a threat to the integrity of the study. 2) Randomized diagnostic studies are probably best placed as singular studies at the end of the process, as all other questions should be clarified before performing such a study. However, otherwise there is a substantial potential for seamless designs. All steps from the construction to the comparison with the comparator can be combined in one protocol. This may include a switch from case-control to population-based recruitment as well as a switch from a single-arm study to a comparative accuracy study. In addition, change-in-management studies can be combined with an outcome study in discordant pairs.CONCLUSION: There is a potential for seamless designs in diagnostic research. It is wise to have the whole sequence of necessary studies in mind and to plan a full programme than rather individual studies one by one
Time to pregnancy after a previous miscarriage in subfertile couples
No full textAbstract not availableTessa Cox, Jan-Willem van der Steeg, Pieternel Steures, Peter G.A. Hompes, Fulco van der Veen, Marinus J.C. Eijkemans, Jules H. Schagen van Leeuwen, Cees Renckens, Patrick M.M. Bossuyt, and Ben W.J. Mo
The added value of second trimester uterine artery Doppler in the identification of nulliparous women at increased risk for preeclampsia: an individual patient data metaanalysis
No full textPoster abstract 390Emily Kleinrouweler, Patrick Bossuyt, Joris van der Post, Javier Arenas, Koen Deurloo, Abdalla Diab, Maureen Macleod, Akihide Ohkuchi, Basky Thilaganathan, Karlijn Vollebregt, Hans Wolf, Ben Mol, Eva Pajkr
Prognostic value of the postcoital test for spontaneous pregnancy
No full textAbstract not availableEsther Leushuis, Jan Willem van der Steeg, Pieternel Steures, Carolien Koks, Jur Oosterhuis, Petra Bourdrez, Patrick M. M. Bossuyt, Fulco van der Veen, Ben Willem J. Mol, and Peter G. A. Hompes, on behalf of the CECERM study grou
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