16,279 research outputs found
Interview with Tim Patrick
No full textTim Patrick talks about his farm and local farming.https://digital.kenyon.edu/elfs_interviews/1037/thumbnail.jp
Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection.
No full textThe S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation. We investigated whether galectin-9/Tim-3 interactions contribute to the deletion and exhaustion of the antiviral T cell response in chronic hepatitis B virus infection (CHB). We found Tim-3 to be expressed on a higher percentage of CD4 and CD8 T cells from patients with CHB than healthy controls (p<0.0001) and to be enriched on activated T cells and those infiltrating the HBV-infected liver. Direct ex vivo examination of virus-specific CD8 T cells binding HLA-A2/peptide multimers revealed that Tim-3 was more highly upregulated on HBV-specific CD8 T cells than CMV-specific CD8 T cells or the global CD8 T cell population in patients with CHB (p<0.001) or than on HBV-specific CD8 after resolution of infection. T cells expressing Tim-3 had an impaired ability to produce IFN-γ and TNF-α upon recognition of HBV-peptides and were susceptible to galectin-9-triggered cell death in vitro. Galectin-9 was detectable at increased concentrations in the sera of patients with active CHB-related liver inflammation (p = 0.02) and was strongly expressed by Kupffer cells within the liver sinusoidal network. Tim-3 blockade resulted in enhanced expansion of HBV-specific CD8 T cells able to produce cytokines and mediate cytotoxicity in vitro. Blocking PD-1 in combination with Tim-3 enhanced the number of patients from whom functional antiviral responses could be recovered and/or the strength of responses, indicating that these co-inhibitory molecules play a non-redundant role in driving T cell exhaustion in CHB. Patients taking antivirals able to potently suppress HBV viraemia continued to express Tim-3 on their T cells and respond to Tim-3 blockade. In summary, both Tim-3 and galectin-9 are increased in CHB and may contribute to the inhibition and deletion of T cells as they infiltrate the HBV-infected liver
Do dolphins benefit from nonlinear mathematics when processing their sonar returns?
No full textAn interview with author Tim Leighton about the paper
Opportunities for linking young surveyors across professional surveying member organisations and FIG
No full textHeaton (Tim B.), Chadwick (Bruce A.) — Statistical handbook on the American family
No full textFesty Patrick. Heaton (Tim B.), Chadwick (Bruce A.) — Statistical handbook on the American family. In: Population, 49ᵉ année, n°2, 1994. pp. 542-543
Heaton (Tim B.), Chadwick (Bruce A.) — Statistical handbook on the American family
No full textFesty Patrick. Heaton (Tim B.), Chadwick (Bruce A.) — Statistical handbook on the American family. In: Population, 49ᵉ année, n°2, 1994. pp. 542-543
Tim Di Muzio on 'Sabotage'
No full textIn a series of essays published in 2013 and 2014 on capitaspower.com, political economist Tim Di Muzio explored the concept of ‘sabotage’ as it applies to capitalist power. I recently rediscovered these essays and was so impressed by them that I have reposted them here as a single piece.
About the author: Tim Di Muzio is a researcher at the University of Wollongong. He is the author of numerous books, including Debt as power, Carbon capitalism, and The 1% and the Rest of us
1996-1997 Tim Gautreaux
No full textTim Gautreaux is the author of three novels and two earlier short story collections. His work has appeared in The New Yorker, The Best American Short Stories, The Atlantic, Harper’s, and GQ. After teaching for thirty years at Southeastern Louisiana University, he now lives, with his wife, in Chattanooga, Tennessee. (Photo credit: Randy Bergeron)https://egrove.olemiss.edu/grisham_res/1023/thumbnail.jp
Tom Daschle, Patrick Leahy, John Melcher, Quentin Burdick, and Tim Johnson on a discussion panel
No full textTom Daschle, Vermont Senator Patrick Leahy, Montana Senator John Melcher, and Tim Johnson on a discussion panel. An Aberdeen Livestock Sales Company sign is on the wall behind them
Patrick Leahy, John Melcher, Quentin Burdick, and Tim Johnson on a discussion panel
No full textVermont Senator Patrick Leahy, Montana Senator John Melcher, North Dakota Senator Quentin Burdick, and Tim Johnson seated at a table. An Aberdeen Livestock Sales Company sign is on the wall behind them
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