7,930 research outputs found
Mechanism of MJ 1999-induced blockade of neuromuscular transmission
No full textAbstract
MJ 1999 [4-(isopropylamino-1-hydroxyethyl)methanesulphonanilide hydrochloride] produced a dose-related blockade of indirectly evoked twitches of the rat diaphragm, without materially altering the effects of direct stimulation. The magnitude of blockade was comparable whether the indirect stimulation was at 1/s or 1/20 s. The blockade was less pronounced at 25° than at 34°. The blockade was antagonized by neostigmine, potassium chloride, succinyl-choline, tetraethylammonium, adrenaline, isoprenaline and, to some extent, by noradrenaline. Blockade by MJ 1999 was additive to that due to tubocurarine; large concentrations of yohimbine, tolazoline, phenoxybenzamine and dihydroergotamine quickly antagonized MJ 1999 blockade. Small concentrations of adrenaline, isoprenaline, tolazoline or yohimbine prevented MJ 1999 blockade. MJ 1999 had no effect on nerve conduction. It is proposed that MJ 1999 has a two-fold mode of action at the neuromuscular junction; a curare-like effect and an action on β-receptors.</jats:p
sj-docx-1-rsh-10.1177_17579139231185999 – Supplemental material for Evaluating the effect of child home safety training upon three family support practitioner groups: a mixed-methods study
No full textSupplemental material, sj-docx-1-rsh-10.1177_17579139231185999 for Evaluating the effect of child home safety training upon three family support practitioner groups: a mixed-methods study by MJ Taylor, T Patel, E Orton, MC Watson, M Hayes, R Clarke, S Stewart, C Timblin and D Kendrick in Perspectives in Public Health</p
Targeted inhibition of βARK1-associated phosphoinositide 3-kinase activity preserves β-adrenergic receptor signaling in heart failure induced by calsequestrin overexpression.
No full textInitial observations on the effect of irradiation on the liver-specific uptake of Levovist.
No full textThe surgical vascular anatomy of the minimally invasive lateral lumbar interbody approach: a cadaveric and radiographic analysis
No full textPurpose: The minimally invasive (MI) lateral lumbar interbody fusion (LLIF) approach has become increasingly popular for the treatment of degenerative lumbar spine disease. The neural anatomy of the lumbar plexus has been studied; however, the pertinent surgical vascular anatomy has not been examined in detail. The goal of this study is to examine the vascular structures that are relevant in relation to the MI-LLIF approach.
Methods: Anatomic dissection of the lumbar spines and associated vasculature was performed in three embalmed, adult cadavers. Right and left surgeon perspective views during LLIF were for a total of six approaches. During the dissection, all vascular elements were noted and photographed, and anatomical relationships to the vertebral bodies and disc spaces were analyzed. In addition, several axial and sagittal MRI images of the lumbar spine were analyzed to complement the cadaveric analysis.
Results: The aorta descends along the left anterior aspect of lumbar vertebra with an average distance of 2.1 cm (range 1.9-2.3 cm) to the center of each intervertebral disc. The vena cava descends along the right anterior aspect of lumbar vertebrates with average distance of 1.4 cm (range 1.3-1.6 cm) to the center of the intervertebral disc. Each vertebral body has two lumbar arteries (direct branches from the aorta); one exits to the left and one to the right side of the vertebral body. The lumbar arteries pass underneath the sympathetic trunk, run in the superior margin of the vertebral body and extend all the way across it, with average length of 3.8 cm (range 2.5-5 cm). The mean distance between the arteries and the inferior plate of the superior disc space is 4.2 mm (range 2-5 mm) and mean distance of 3.1 cm (range 2.8-3.8 cm) between two arteries in adjacent vertebrae. One of the cadavers had an expected normal anatomical variation where the left arteries at L3-L4 anastomosed dorsally of the vertebral bodies at the middle of the intervertebral disc.
Conclusions: Understanding the vascular anatomy of the lateral and anterior lumbar spine is paramount for successfully and safely executing the LLIF procedure. It is imperative to identify anatomical variations in lumbar arteries and veins with careful assessment of the preoperative imaging
Self-compression of 4.9 µm pulses to sub-40 fs with 2 mJ energy in Zinc Sulfide
No full textNonlinear self-compression of few-cycle multi-mJ pulses at 4.9 µm in ZnS is presented. 80 fs input pulses are compressed to 37 fs with 2.1 mJ energy at a 1 kHz repetition rate. © 2024 The Author(s
Erythropoietin in the intensive care unit: beyond treatment of anemia
No full textThis is an Open Access article distributed under the terms of the Creative Commons Attribution
License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium,
provided the original work is properly cited
The design and development of a decision support package for low back pain
No full textArthritis Care & Research is published by Wiley
Periodicals, Inc. on behalf of the American College of Rheumatology.
This is an open access article under the terms of the Creative Commons
Attribution-NonCommercial-NoDerivs License, which permits use and
distribution in any medium, provided the original work is properly cited,
the use is non-commercial and no modifications or adaptations are made.Objective: To develop a decision support package for people with low back pain (LBP) referred for physiotherapy. Methods: A programme of exploratory work including, literature reviews, a Delphi study, a nominal group with physiotherapists, focus groups with patients' and secondary analysis of existing interview data. Results: We developed an information booklet describing the evidence-based treatment modalities available in a physiotherapy department. This includes data on likely benefits and risks and how the intervention is delivered. The booklet specifically addresses questions identified as important in our exploratory work. Space is provided for patients to note down the pros and cons of each treatment and what matters to them when choosing treatments. The patient is subsequently directed to a section that explores any gaps in knowledge, values, support and choice before finally clarifying if a treatment decision is possible. At this stage they are encouraged to note down any questions or concerns they have to be discussed at the first physiotherapy consultation. This overall package includes patient material in the form of a booklet, posted prior to their consultation, plus the enhanced consultation with the specially trained physiotherapist. Patients then receive their chosen treatment. In addition we developed a training package for physiotherapists that explains the content of the booklet and supports them in using informed shared decision making in their consultation. Conclusion: This package has the potential to improve effectiveness of treatments and patient satisfaction for LBP by facilitating patient choice and thus matching patients more effectively to different treatments. © 2013 American College of Rheumatology
Original data files for Hirt et al 2022 (Nat. Comm)
No full textOriginal data for charts and tables in: Hirt H, Greenwood-Quaintance KE, Barnes AMT, Karau MJ, Till LM, Palzer E, Guan W, VanNieuwenhze MS, Kashyap PC, Patel R, and GM Dunny (2022). Dynamics of Plasmid-mediated Niche Invasion, Immunity to invasion, and Pheromone-inducible Conjugation in the Murine Gastrointestinal Tract. Nature Communications.</div
Correction to: Chamoun et al., Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection
No full textChamoun MN, Blumenthal A, Sullivan MJ, Schembri MA, Ulett GC. 2018. Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection. Critical Reviews in Microbiology. https://doi.org/10.1080/1040841X.2018.1426556.
When the above article was first published online, the below three corrections were missed.
The author ‘Antje Blumenthal’ was wrongly affiliated to the affiliation “cSchool of Chemistry and Molecular Biosciences, and Australian Infectious Disease Research Centre, The University of Queensland, Brisbane, Australia”. Now this affiliation has been removed for this author.
The affiliation ‘bTranslational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia’ of the author ‘Antje Blumenthal’ should read ‘bThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia’.
In Table 3, the sentence ‘Benefit of manipulating IL-17 levels to improve immunization strategies M. tuberculosis’ should read “Benefit of manipulating IL-17 levels to improve immunization strategies against M. tuberculosis”.No Full Tex
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