33 research outputs found
Inter-Device Communication in Near Storage Computation
No full textNear storage computation has increasingly become a focus in improving the performance of big data systems. Technological trends have moved the bottle neck of data intensive workloads to the interconnects used to move data from storage to memory. This has given a rise to the need for moving processing power closer to where the data is stored. The solution presented in this paper aims to provide a developer friendly approach to computational storage that allows multiple computational storage capable devices to be used effectively by enabling data transfer between computational storage devices directly. In this work, we build a model system on Amazon AWS and run a merge sort workload to evaluate the benefits of allowing device to device communication. We identify the scenarios in which device to device communication is effective and propose additional optimizations and improvements to better the overall solution
Stability Studies of F16 and JFD in Lipophilic and PBS Formulations in Different Storage Conditions
No full textThe term Angiogenesis implies the formation of new blood vessels. In cancer cells, angiogenesis plays a critical role in the cell growth and in the spread of cancer. F16 and JFD, two drugs patented by Dr. Appu Rathinavelu, specifically inhibit vascular endothelial growth factor receptors (VEGFRs). These drugs are going to be tested in clinical trials but first must undergo drug stability testing of the existing formulations. Therefore, the purpose of this study was to investigate the stability of F16 and JFD in order to determine the storage conditions in which the therapeutic activity of the drugs will be maintained. Two different formulations were prepared for F16, JFD and JFD-WS: solubilizing the drugs in Lipophilic and PBS. The samples were kept at 25oC and 5oC, and the degradation of the drugs was determined by drawing the samples after initial (0), 1, 7, 14, 30 and 60 days interval using the HPLC method. The results showed that the concentration of the drugs remained constant in Lipophilic formulations after sampling intervals of 60 and 14 days respectively. However, the percent content of JFD in PBS formulation was reduced at day 14 compared to initial day (0) due to the recrystallization of JFD in the buffer formulation during storage. The preliminary data of this study shows the potential of creating a stable formulation for the clinical use of both novel drugs, F16 and JFD. This project was supported by The Royal Dames of Cancer Research Inc., Fort Lauderdale, Florida
Dynamic modeling of the heat pipe-assisted annealing line
No full textIn a conventional continuous annealing line, the energy supplied to steel strip during heating is not recovered while cooling it. Therefore, an alternative heat transfer technology for energy efficient continuous annealing of steel was developed. This technology enables reusing the heat extracted during cooling of the strip in the heating part of the process. This is achieved by thermally linking the cooling strip to the heating strip via multiple rotating heat pipes. In this context, the dynamic simulation of a full heat pipe assisted annealing line is performed. The dynamic simulation consists of the interaction of computational building blocks, each comprising of a rotating heat pipe and strip parts wrapped around the heat pipe. The simulations are run for different installation configurations and operational settings, with the heat pipe number varying between 50 and 100 and with varying strip line speed and dimensions. The heat pipes are sized to be 0.5 m in diameter and 3 m in length. The simulation results show that the equipment is capable of satisfying the thermal cycle requirements of annealing both at steady-state and during transition between steady-states following changes in boundary conditions. With this concept, energy savings of up to 70% are feasible.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Large Scale Energy StorageProcess and EnergyEnergy Technolog
Ultra-thin friction stir welding on Aluminum alloy
No full textUltra-thin sheets' welding is an intricate process either by conventional or advanced techniques. In the present investigation, Micro friction stir welding (FSW) was successfully performed to join the ultra-thin (0.5 mm thick) commercial aluminum. Suitable fixture and tool were developed for the ultra-thin sheets to perform experiments. Velocity ratio of rotational speed to transvers speed was varied to obtain ultra-thin friction stir welding. The welded samples were investigated by visual examination, macro-graphs, microstructure, tensile testing with fracture surface analysis and micro hardness distribution. The results revealed that, the sound joint was achieved at the velocity ratio of 13.71. The tensile strength of 100.877 N/mm2 and elongation of 23.12% were obtained, which were 90.77% and 51.377% of the parent material respectively. Fracture surfaces after tensile testing was observed with elongated dimples indicating ductile fracture. The maximum micro hardness of 94 HV was observed in the weld zone
Cytokine release syndrome in patients treated with chimeric antigen receptor T-cell therapy: A retrospective study analyzing risks, outcomes, and healthcare burden
No full textBackground Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a promising immunotherapy for various malignancies. However, its use is associated with challenges, including cytokine release syndrome (CRS), a potentially severe complication. This retrospective study aims to analyze the risks, outcomes, and healthcare burden of CRS in patients undergoing CAR-T therapy. Method Data from the 2020 National Inpatient Sample (NIS) were utilized, comprising 415 CAR-T-related hospitalizations. They were categorized into those with CRS (n = 68) and those without CRS (n = 347). Baseline characteristics, including age, gender, race, income, insurance status, and comorbidities, were compared. Outcomes of interest included in-hospital mortality, length of stay (LOS), total hospital charges, and access to complications, associations, and interventions. Statistical analyses, including multivariable models, were employed to assess associations. Results Hospitalizations with CRS did not exhibit significant differences in age, gender, race, income, or insurance status compared to those without CRS. The multivariable analysis showed no statistically significant difference in mortality (adjusted odds ratio (aOR) = 2.48, 95% confidence interval (CI): 0.71 to 8.69, p = 0.151), LOS (coefficient = -2.1 days, 95% CI: -5.43 to 1.21, p = 0.207), or total hospital charges (coefficient = 6119 to $421,031, p = 0.057) between the two groups. The CRS group had a higher incidence of fever (aOR = 1.91, 95% CI: 1.15 to 3.17, p = 0.014), acute respiratory failure (aOR = 2.10, 95% CI: 1.01 to 4.40, p= 0.049), and the need for intubation/mechanical ventilation (aOR = 2.59, 95% CI: 1.14 to 5.88, p = 0.024). Hemophagocytic lymphohistiocytosis (HLH) was significantly associated with CRS (aOR = 6.72, 95% CI: 2.03 to 22.18, p = 0.002). Conclusion While the development of CRS in CAR-T-treated patients did not significantly increase mortality, LOS, or total hospital charges, it was associated with specific risks and outcomes, including fever, respiratory failure, and HLH. This study emphasizes the importance of vigilance in recognizing and managing CRS in CAR-T therapy to optimize patient outcomes. The findings contribute valuable insights to guide clinical decision-making in the context of CAR-T therapy
Ultra-thin friction stir welding on Aluminum alloy
No full textUltra-thin sheets’ welding is an intricate process either by conventional or advanced techniques. In the present investigation, Micro friction stir welding (FSW) was successfully performed to join the ultrathin (0.5 mm thick) commercial aluminum. Suitable fixture and tool were developed for the ultra-thin sheets to perform experiments. Velocity ratio of rotational speed to transvers speed was varied to obtain ultra-thin friction stir welding. The welded samples were investigated by visual examination, macrographs, microstructure, tensile testing with fracture surface analysis and micro hardness distribution. The results revealed that, the sound joint was achieved at the velocity ratio of 13.71. The tensile strength of 100.877 N/mm2 and elongation of 23.12% were obtained, which were 90.77% and 51.377% of the parent material respectively. Fracture surfaces after tensile testing was observed with elongated dimples indicating ductile fracture. The maximum micro hardness of 94 HV was observed in the weld zone.Peer reviewe
