587 research outputs found
Kunal Patel
No full textKunal Patel
Kunal Patel is a technology and creative entertainment professional with over 10 years of experience in leadership roles, software development, sales and creative production. He serves as president of Phyken Media a full service video game production studio housing artists, designers and developers with active work building digital experiences for NASA Kennedy Space Center Visitor Complex. As Director of Innovation at Fattmerchant, a local Orlando payment tech he build resources for efficiency and strategic partnerships. As cofounder of Indienomicon, the largest community organization for game studios in the South East US, he helped to grow local community talent from 6 studios in 2013 to 40+ by 2016 sparking economic development and structure around talent. In 2015 cofounded Indie Galactic Space Jam, a successful annual collaborative event between the Orlando Games Industry and the Space industries to rapidly prototype games that drive excitement for space travel and exploration. His latest venture is the Orlando Game Space a collaborative game co-working facility to provide resources to indie game developers and robust professional services in Games, Digital Media, VR, AR Development to the marketplace.https://commons.erau.edu/space-congress-bios-2016/1051/thumbnail.jp
Watershed modeling using HEC-RAS, HEC-HMS, and GIS models: a case study of the Wreck Pond Brook Watershed in Monmouth County, New Jersey
No full textManaging stormwater on a watershed basis is considered the best strategy to address flooding. A watershed model should provide temporal and spatial distribution of runoff response for a given storm. GIS applicability in watershed modeling is increasing due to the availability of spatial information, fast processors and interfaces such as ArcHydro, HEC-GeoHMS, and HEC-GeoRAS linking hydrologic and hydraulic models to the ArcGIS environment.
Soil Conservation Service methods are used widely in hydrologic models. Several parameters inherent to these empirical methods are average values derived from various watershed conditions. These average values overestimate peak flows for flat, low-lying coastal terrains. The design of flood control structures based on these flow values allow more post-development discharge, make the system more hydraulically efficient, increase project costs, and cause flooding for areas downstream. In this study, Wreck Pond Brook Watershed (WPBW), a coastal New Jersey area was used for sensitivity studies of the initial abstraction ratio and peak rate factor. The HEC-HMS modeling results indicated use of a lower peak rate factor (e.g. 284) and 5% initial abstraction ratio provided better characterization of stream response. These updated parameters provide new technical information for improving stormwater management in coastal areas.
An important limitation in hydraulic modeling is the economic constraint on cross-section spacing for surveying channels and floodplains. Applying GIS techniques in hydraulic modeling eliminated this constraint. Floodplain analysis was done using ArcGIS, HEC-GeoRAS and HEC-RAS. Detailed elevation data (LIDAR information from Monmouth County) was incorporated into the HEC-RAS using GIS models. This innovation was important for improving model efficiency. The modeled floodplain demonstrated close agreement to the observed floodplain for the October 2005 storm and showed greater accuracy compared to the FEMA floodplain for the 100-year storm. This study validated use of LIDAR elevation data in floodplain analysis for the second-order streams in coastal NJ.
Finally, an approach was demonstrated using modeled floodplain and HEC-HMS for flood control analysis. This study presents an innovative watershed modeling approach using GIS models while addressing the limitations of traditional hydrologic and hydraulic methods using WPBW as an example.Ph.D.Includes bibliographical references (p. 259-263)by Kunal P. Pate
First person – Kunal Chopra
No full textFirst Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Kunal Chopra is first author on ‘Zebrafish duox mutations provide a model for human congenital hypothyroidism’, published in BIO. Kunal is a PhD student in the lab of Enrique Amaya at the University of Manchester, investigating reactive oxygen species in wound healing and regeneration
sj-pdf-1-vmj-10.1177_1358863X231205574 – Supplemental material for Impact of preexisting coronary artery and peripheral artery disease on outcomes in diabetic patients after kidney transplant
No full textSupplemental material, sj-pdf-1-vmj-10.1177_1358863X231205574 for Impact of preexisting coronary artery and peripheral artery disease on outcomes in diabetic patients after kidney transplant by Sania Jiwani, Wan-Chi Chan, Monil Majmundar, Kunal N Patel, Harsh Mehta, Aditya Sharma, Gaurav Parmar, Mark Wiley, Peter Tadros, Eric Hockstad, Sri G Yarlagadda, Aditi Gupta and Kamal Gupta in Vascular Medicine</p
sj-docx-2-ine-10.1177_15910199241234098 - Supplemental material for Transvenous embolization of noncavernous dural arteriovenous fistulas (dAVFs): A systematic review and meta-analysis
No full textSupplemental material, sj-docx-2-ine-10.1177_15910199241234098 for Transvenous embolization of noncavernous dural arteriovenous fistulas (dAVFs): A systematic review and meta-analysis by Jaims Lim, Brianna M. Donnelly, Vinay Jaikumar, Marissa D. Kruk, Cathleen C. Kuo, Andre Monteiro, Manhal Siddiqi, Ammad A. Baig, Devan Patel, Kunal P. Raygor, Kenneth V. Snyder, Jason M. Davies, Elad I. Levy and Adnan H. Siddiqui in Interventional Neuroradiology</p
sj-docx-1-ine-10.1177_15910199241234098 - Supplemental material for Transvenous embolization of noncavernous dural arteriovenous fistulas (dAVFs): A systematic review and meta-analysis
No full textSupplemental material, sj-docx-1-ine-10.1177_15910199241234098 for Transvenous embolization of noncavernous dural arteriovenous fistulas (dAVFs): A systematic review and meta-analysis by Jaims Lim, Brianna M. Donnelly, Vinay Jaikumar, Marissa D. Kruk, Cathleen C. Kuo, Andre Monteiro, Manhal Siddiqi, Ammad A. Baig, Devan Patel, Kunal P. Raygor, Kenneth V. Snyder, Jason M. Davies, Elad I. Levy and Adnan H. Siddiqui in Interventional Neuroradiology</p
Opportunities and challenges of investing in Indian real estate
No full textThesis (S.M.)--Massachusetts Institute of Technology, Program in Real Estate Development in Conjunction with the Center for Real Estate , 2009.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student submitted PDF version of thesis.Includes bibliographical references (p. 125-128).In recent years, global real estate investment has become an important component of efficient global mixed asset portfolios. Although these investments carry increased political, regulatory and currency risk, international real estate investment has been on the rise. Compelling macroeconomic and demographic trends along with improvements in structural and regulatory conditions and investment in infrastructure are driving strong real estate capital flows into the emerging markets. This thesis provides a study of the opportunities and challenges of investing in one emerging market, India. With a population of over 1 billion, India has been a major beneficiary of the "Globalization of Real Estate". This thesis identifies the opportunities in India that have caused global capital to flow into Indian real estate and the key factors driving Indian real estate. It explains the challenges of investing in Indian real estate and seeks to provide strategies for navigating the real estate landscape in India.by Kunal Wadhwani.S.M
Mobile (wireless) telecommunication sector: an Indian perspective and PESTLE analysis
No full textRevolutionary changes in how people interact while travelling at a distance have given rise to several mobile communication tactics. Numerous generations of Mobile telecommunications/telephony have progressed as 1G, 2G, 3G, 4G, 5G, and 6G (now under research). However, in the context of India, mobile telephony can be realized from 2G. The sector has directly or indirectly been impacted by political, social, economic, technological, legal, and environmental (PESTLE) aspects. Therefore, the study objectives are first to discuss the (mobile) telecom sector evolution outline and, second, the factors that contributed to sectoral development by the PESTLE framework. The conceptual foundation of the work is secondary sources
Computational modeling of intrinsic dissipation in nano-structure
No full textIn this work, using computational modeling, we study the different mechanisms of intrinsic dissipation in nano-electro mechanical systems (NEMS). We, first, use molecular dynamics (MD) simulation and gain an understanding of the underlying loss mechanisms. Using insights from the MD simulation, a multi-scale method to model intrinsic damping is developed. The high frequency vibration in NEMS have important applications. A few examples include the sensing of atomic mass, detection of biological molecules and observation of quantum effects in macroscopic objects. For all these potential applications, dissipation plays a limiting role. While a number of experimental and theoretical studies have been performed, the individual role of different mechanisms remains unclear. In this work, we attempt to isolate and understand the surface and size effect on some of the intrinsic mechanisms. We, first, consider the case of the Akhiezer damping. The Akhiezer dynamics is expected to play an important role in nano-resonators with frequencies in the GHz range. Using a judiciously devised MD set-up, we isolate Akhiezer dynamics. We show that the surfaces aid in reducing the dissipation rate through increasing the rate of thermalization of the phonons. We, next, study damping under the flexure mode of operation. A comparative analysis with the stretching mode shows that the flexure mode is less dissipative. A reduced order model is considered to understand this novel behavior. We, also, investigate the role of tension on the Q factor, a measure of the inverse of dissipation rate.
From these studies, we conclude that Akhiezer dynamics plays a dominant role in nano-resonators. We, then, develop a quasi-harmonic based multi-scale method to model Akhiezer damping. A stress component, that characterizes the non-equilibrium phonon population, is derived. We obtain constitutive relation that governs the time evolution of the non-equilibrium stress. Different methods to parametrize the constitutive relation are discussed. Using the proposed formulation, we compute the dissipation rate for different cases. The results are compared with those obtained using MD. Next, we use the Boltzmann transport equation and investigate the Q factor due to the thermo-elastic dissipation (TED). The Q factor obtained shows deviations from the classical theory of TED. Correction to the classical formula, for the case of longitudinal modes, is provided.
We, then, study damping is low dimensional structure. We first consider the case of two dimensional graphene sheet and under in-plane stretching. We show that the coupling between the in-plane and the out-of-plane motions plays an important role in the loss of mechanical energy. Further, a hysteresis behavior in the out-of-plane dynamics is observed. Next, we investigate the stretching motion of graphene nano-ribbon. A normal mode Langevin dynamics is devised to understand the results from the MD simulation.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-05-01The student, Kumar Kunal, accepted the attached license on 2015-12-23 at 11:24.The student, Kumar Kunal, submitted this Dissertation for approval on 2015-12-23 at 11:27.This Dissertation was approved for publication on 2016-01-04 at 13:54.DSpace SAF Submission Ingestion Package generated from Vireo submission #9026 on 2016-07-07 at 13:48:03Made available in DSpace on 2016-07-07T20:26:39Z (GMT). No. of bitstreams: 2
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Proanthocyanidins from the American Cranberry (Vaccinium macrocarpon) inhibit matrix metalloproteinase-2 and matrix metalloproteinase-9 activity in human prostate cancer cells via alterations in multiple cellular signalling pathways
No full textProstate cancer is one of the most common cancers in the Western world, and it is believed that an individual's diet affects his risk of developing cancer. There has been an interest in examining phytochemicals, the secondary metabolites of plants, in order to determine their potential anti-cancer activities in vitro and in vivo. In this study we document the effects of proanthocyanidins (PACs) from the American Cranberry (Vaccinium macrocarpon) on matrix metalloproteinase (MMP) activity in DU145 human prostate cancer cells. Cranberry PACs decreased cellular viability of DU145 cells at a concentration of 25 mu g/ml by 30% after 6 h of treatment. Treatment of DU145 cells with PACs resulted in an inhibition of both MMPs 2 and 9 activity. PACs increased the expression of TIMP-2, a known inhibitor of MMP activity, and decreased the expression of EMMPRIN, an inducer of MMP expression. PACs decreased the expression of PI-3 kinase and AKT proteins, and increased the phosphorylation of both p38 and ERK1/2. Cranberry PACs also decreased the translocation of the NF-kappa B p65 protein to the nucleus. Cranberry PACs increased c-jun and decreased c-fos protein levels. These results suggest that cranberry PACs decreases MMP activity through the induction and/or inhibition of specific temporal MMP regulators, and by affecting either the phosphorylation status and/or expression of MAP kinase, PI-3 kinase, NF-kappa B and AP-1 pathway proteins. This study further demonstrates that cranberry PACs are a strong candidate for further research as novel anti-cancer agents. J. Cell. Biochem. 111: 742-754, 2010. (c) 2010 Wiley-Liss, Inc
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