99 research outputs found
Formulation and development of a self-nanoemulsifying drug delivery system of irbesartan
No full textIrbesartan (IRB) is an angiotensin II receptor blocker antihypertensive agent. The aim of the present investigation was to develop a self-nanoemulsifying drug delivery system (SNEDDS) to enhance the oral bioavailability of poorly water-soluble IRB. The solubility of IRB in various oils was determined to identify the oil phase of SNEDDS. Various surfactants and co-surfactants were screened for their ability to emulsify the selected oil. Pseudoternary phase diagrams were constructed to identify the efficient self-emulsifying region. The optimized SNEDDS formulation contained IRB (75 mg), Cremophor® EL (43.33%), Carbitol® (21.67%) and Capryol® 90 (32%). SNEDDS was further evaluated for its percentage transmittance, emulsification time, drug content, phase separation, dilution, droplet size and zeta potential. The optimized formulation of IRB-loaded SNEDDS exhibited complete in vitro drug release in 15 min as compared with the plain drug, which had a limited dissolution rate. It was also compared with the pure drug solution by oral administration in male Wister rats. The in vivo study exhibited a 7.5-fold increase in the oral bioavailability of IRB from SNEDDS compared with the pure drug solution. These results suggest the potential use of SNEDDS to improve dissolution and oral bioavailability of poorly water-soluble IRB
Design and Development of Novel Drug Delivery Systems of Angiotensin II Receptor Blockers for Oral Drug Delivery
No full textNot availabl
Automated Systems Control for In-Vacuo Liquid Jet Sample Delivery
No full textA thesis submitted in total fulfillment of the requirements for the degree of Doctor of Philosophy to the School of Computing, Engineering and Mathematical Sciences, La Trobe University, Victoria, Australia.</p
Cylinder drag reduction by geometric modification in 3-Diameter confined space: Towards speed skiing application
No full textCylinder flow has been extensively studied for decades due to its numerous direct and indirect relevance to the real-life applications. Being a bluff body, the cylinder experiences flow separation with large wake leading to significant drag force thus the drag reduction on the cylinder is sought. In the long-running history of cylinder flow, drag reduction is achieved by geometric modification, active/passive flow control techniques. The aim of this research is to investigate the drag reduction on the cylinder with the help of geometric modification and passive flow control devices. The geometric modifications are restricted tobe made only in the downstream direction from the cylinder leading point within the constrained space of 3 diameters. The constraints are inspired from speed skiing fairing design and other applications where a complete aerofoil cannot be fitted due to limited available space. The passive flow control devices like zigzag strip and vortex generator are implemented on the modified geometry to seek further drag reduction.Aerospace Engineerin
Study of maternal and perinatal outcome in abruptio placentae
No full textBackground: Abruptio placentae is very frequently seen in our population. Few studies have reported maternal and fetal morbidity and mortality associated with this condition. No work has been done on abruptio placentae in our setup. The data generated will help to improve maternal and fetal morbidity and mortality by planning prompt management of future cases of placental abruption. Objective of this study was to study possible etiological factors of abruptio placentae, analyse maternal outcome, perinatal outcome in the form of maternal morbidity and mortality and discuss possible preventive measures and future management optionMethods: The retrospective observational study it was included all cases presenting with ante partum haemorrhage during the study period. Subjects selected for the study were all cases diagnosed as having abruptio placentae. All other causes of APH like placenta previa and other extraplacental causes were excluded.Results: In the present study incidence of abruptio placentae is higher in 25-30 year that were 42.5% and more in 2nd gravida patient. PIH was accounting for 50%, most of the patients (95%) were anaemic at admission and majority of them required blood transfusion.one maternal mortality (2.5%) occurred, perinatal mortality was 75%.Conclusions: Abruptio placentae serious condition with manifestation of significant maternal and perinatal morbidity and mortality. Complications can be reduced by provisional antenatal care to every woman and with improvement in medical facilities, availability of blood transfusion, proper management of shock. With liberalization of caesarean section, the rate of maternal morbidity and mortality is gradually on the decline
Effect of Combining Teaching Learning-Based Optimization (TLBO) with Different Search Techniques
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Nature-Inspired Wind Farm Layout Optimization: Harnessing Smart Patterns for Sustainable Energy
No full textThis research investigates the transformative realm of wind farm layout optimization, with a specific focus on harnessing the efficiency of bio-inspired patterns. The positioning of wind turbine is play a vital role in the maximizing the energy output of a wind farm. If a wind turbine is placed in the wake region of the upstream turbine, the energy produced by the downstream turbine is reduced. Hence, it is imperative to place turbines in such a way that effect of the wake is minimum on a performance of turbines. The conventional grid-based approaches, commonly employed in wind farm layouts, face limitations in capturing the inherent complexity of wind flow dynamics, especially in varied terrains. In contrast, bio-inspired layouts, inspired by patterns observed in natural ecosystem, offer the promising results over the conventional Grid based approach. Our investigation involves the development and implementation of a novel bio-inspired wind farm layout positioning pattern. In the proposed approach, various nature inspired pattern like honeycomb and sunflower seeds pattern is explored for the turbine positioning. Further, the modeling of wind behavior includes both uniform wind speeds and variable wind speeds originating from all directions. The modified passing vehicle search (mPVS) optimization algorithm is used for optimizing the wind turbine placement. The results are obtained for the different wind scenario and compare it with the available results in the literature. The anticipated outcomes of this research include a deeper understanding of the potential benefits and challenges associated with bio-inspired wind farm layouts. The findings aim to contribute valuable insights into optimizing wind turbine placements, maximizing energy capture, and fostering sustainable practices in the wind energy sector. Results shows that the turbine positioning in the proposed bio-inspired pattern produce the higher power output (6%) compared to the conventional grid based approach. Hence, it can be concluded that the approach present in this study can assist wind farm designers and developers in optimally placing turbines for better performance
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