65,125 research outputs found
Synthesis of an unnatural product - 4,4' biaryl formation as a macrocyclisation step
No full textA correction to the paper Patel, H. K., Kilburn, J. D., Langley, G. J., Edwards, P. D., Mitchell, T., & Southgate, R. (1994). Synthesis of an unnatural product -- 4,4′ biaryl formation as a macrocyclisation step. Tetrahedron Letters, 35(3), 481-484. https://doi.org/10.1016/0040-4039(94)85086-
Castianeira tinae Patel & Patel 1973
No full textCastianeira tinae Patel & Patel, 1973 Castianeira Tinae Patel & Patel, 1973: 6, fig. 3a–g (♂ ♀). Castianeira tinae: Feng, 1990: 173, fig. 148.1–4 (not ♂, ♀); Majumder & Tikader, 1991: 140, figs 292–296 (♀). Remarks. This species was described based on male and female specimens collected from Vallabh Vidhyanagar (22 o 32’51.56’’N, 72 o 55’30.50’’E; 41 m alt) in Gujarat. The type material of this species was not examined as it is not deposited in NZC-ZSI. It is noteworthy that Patel and Patel (1973) provided no repository information for this species. The original illustrations, even though they are highly schematic, provide hints regarding similarity of this species with Castianeira zetes Simon, 1897, particularly the shape and orientation of the embolus, and outline of the epigyne. The male pedipalp of this species illustrated in Feng (1990: figs 148.3–4) is, however, not of a Castianeira species, but is of Corinnomma severum (Thorell, 1887) (cf. Feng 1990: fig. 148.3 and Deeleman-Reinhold 2001: fig. 469). The subsequent illustrations of the epigyne of C. tinae (Feng 1990: fig. 148.1–2; Majumder & Tikader 1991: figs 293–294) also indicate its resemblance to C. zetes. However, its synonymy with C. zetes can only be confirmed after examining the type specimen of the species.Published as part of Sankaran, Pradeep M., Caleb, John T. D. & Sebastian, Pothalil A., 2019, New synonymies and transfers in Castianeira Keyserling, 1879 (Araneae, Corinnidae, Castianeirinae) from India, pp. 331-340 in Zootaxa 4623 (2) on page 332, DOI: 10.11646/zootaxa.4623.2.7, http://zenodo.org/record/325549
Serum vitamin D and cardiometabolic risk factors in the UK population
No full textLow serum 25-hydroxyvitamin D (25(OH)D) concentrations have been associated with greater adiposity and an adverse cardiometabolic risk profile, yet findings are inconsistent and the role of vitamin D status in cardiovascular disease (CVD) remains uncertain. We aimed to examine the associations between serum 25(OH)D and CVD risk factors in the British population. We analysed data on 2842 subjects aged ≥40 years enrolled in the National Diet and Nutrition Survey (NDNS 2008-2018). Based on serum 25(OH)D concentrations, study subjects were grouped in three categories: vitamin D deficiency (<25 nmol/L), vitamin D insufficiency (25-49 nmol/L) and vitamin D sufficiency status (≥50 nmol/mL). Differences in CVD risk factors between vitamin D deficiency or insufficiency and vitamin D sufficiency status were expressed in standard deviation scores (SDSs) and estimated through weighted multiple linear regression models. We found that vitamin D deficiency was directly associated with BMI, waist circumference, triglycerides and inversely associated with high-density lipoprotein cholesterol (HDL) values. The strongest associations were found between vitamin D deficiency and triglycerides (0.50 SDS, 95% CI: 0.24, 0.77) among men, and vitamin D deficiency and waist circumference (0.70 SDS, 95% CI: 0.56, 0.94), BMI (0.63 SDS, 95% CI: 0.39, 0.88) and triglycerides (0.54 SDS, 95% CI: 0.30, 0.77) among women. When adjusting for BMI the association with triglyceride attenuated (from 0.50 SDS to 0.39 SDS among men and from 0.54 SDS to 0.30 SDS among women). Our data indicates a relationship between inadequate vitamin D status and an adverse CVD risk profile. However, interventional studies are needed to establish possible benefits of vitamin D supplementation on cardiovascular risk. This article is protected by copyright. All rights reserved
Inclusive decays B->DX and B->D*X
No full textComplete Author List: Gibbons L, Johnson SD, Kwon Y, Roberts S, Thorndike EH, Jessop CP, Lingel K, Marsiske H, Perl ML, Schaffner SF, Ugolini D, Wang R, Zhou X, Coan TE, Fadeyev V, Korolkov I, Maravin Y, Narsky I, Shelkov V, Staeck J, Stroynowski R, Volobouev I, Ye J, Artuso M, Efimov A, Frasconi F, Gao M, Goldberg M, He D, Kopp S, Horwitz N, Moneti GC, Mountain R, Mukhin Y, Schuh S, Skwarnicki T, Stone S, Thulasidas M, Viehhauser G, Xing X, Bartelt J, Csorna SE, Jain V, Marka S, Freyberger A, Godang R, Kinoshita K, Lai IC, Pomianowski P, Schrenk S, Bonvicini G, Cinabro D, Greene R, Perera LP, Barish B, Chadha M, Chan S, Eigen G, Miller JS, OGrady C, Schmidtler M, Urheim J, Weinstein AJ, Wurthwein F, Asner DM, Bliss DW, Brower WS, Masek G, Paar HP, Sharma V, Gronberg J, Kutschke R, Lange DJ, Menary S, Morrison RJ, Nelson HN, Nelson TK, Qiao C, Richman JD, Roberts D, Ryd A, Witherell MS, Balest R, Behrens BH, Cho K, Ford WT, Park H, Rankin P, Roy J, Smith JG, Alexander JP, Bebek C, Berger BE, Berkelman K, Bloom K, Cassel DG, Cho HA, Coffman DM, Crowcroft DS, Dickson M, Drell PS, Ecklund KM, Ehrlich R, Elia R, Foland AD, Gaidarev P, Gittelman B, Gray SW, Hartill DL, Heltsley BK, Kandaswamy J, Katayama N, Kim PC, Kreinick DL, Lee T, Liu Y, Ludwig GS, Masui J, Mevissen J, Mistry NB, Ng CR, Nordberg E, Ogg M, Patterson JR, Peterson D, Riley D, Soffer A, Ward C, Athanas M, Avery P, Jones CD, Lohner M, Prescott C, Yang S, Yelton J, Zheng J, Brandenburg G, Briere RA, Gao YS, Kim DYJ, Wilson R, Yamamoto H, Browder TE, Li F, Li Y, Rodriguez JL, Bergfeld T, Eisenstein BI, Ernst J, Gladding GE, Gollin GD, Hans RM, Johnson E, Karliner I, Marsh MA, Palmer M, Selen M, Thaler JJ, Edwards KW, Bellerive A, Janicek R, MacFarlane DB, McLean KW, Patel PM, Sadoff AJ, Ammar R, Baringer P, Bean A, Besson D, Coppage D, Darling C, Davis R, Hancock N, Kotov S, Kravchenko I, Kwak N, Anderson S, Kubota Y, Lattery M, ONeill JJ, Patton S, Poling R, Riehle T, Savinov V, Smith A, Alam MS, Athar SB, Ling Z, Mahmood AH, Severini H, Timm S, Wappler F, Anastassov A, Blinov S, Duboscq JE, Fisher KD, Fujino D, Fulton R, Gan KK, Hart T, Honscheid K, Kagan H, Kass R, Lee J, Spencer MB, Sung M, Undrus A, Wanke R, Wolf A, Zoeller MM, Nemati B, Richichi SJ, Ross WR, Skubic P, Wood M, Bishai M, Fast J, Gerndt E, Hinson JW, Menon N, Miller DH, Shibata EI, Shipsey IPJ, Yurko M</p
Measurement of the B̄→D*lν̄ branching fractions and -Vcb-
No full textcomplete author list:
Barish B.; Chadha M.; Chan S.; Cowen D.; Eigen G.; Miller J.; O'Grady C.; Urheim J.; Weinstein A.; Acosta D.; Athanas M.; Masek G.; Paar H.; Gronberg J.; Kutschke R.; Menary S.; Morrison R.; Nakanishi S.; Nelson H.; Nelson T.; Qiao C.; Richman J.; Ryd A.; Tajima H.; Sperka D.; Witherell M.; Procario M.; Balest R.; Cho K.; Daoudi M.; Ford W.; Johnson D.; Lingel K.; Lohner M.; Rankin P.; Smith J.; Alexander J.; Bebek C.; Berkelman K.; Bloom K.; Browder T.; Cassel D.; Cho H.; Coffman D.; Crowcroft D.; Drell P.; Ehrlich R.; Gaidarev P.; Galik R.; Garcia-Sciveres M.; Geiser B.; Gittelman B.; Gray S.; Hartill D.; Heltsley B.; Jones C.; Jones S.; Kandaswamy J.; Katayama N.; Kim P.; Kreinick D.; Ludwig G.; Masui J.; Mevissen J.; Mistry N.; Ng C.; Nordberg E.; Patterson J.; Peterson D.; Riley D.; Salman S.; Sapper M.; Würthwein F.; Avery P.; Freyberger A.; Rodriguez J.; Yang S.; Yelton J.; Cinabro D.; Henderson S.; Liu T.; Saulnier M.; Wilson R.; Yamamoto H.; Bergfeld T.; Eisenstein B.; Gollin G.; Ong B.; Palmer M.; Selen M.; Thaler J.; Edwards K.; Ogg M.; Bellerive A.; Britton D.; Hyatt E.; MacFarlane D.; Patel P.; Spaan B.; Sadoff A.; Ammar R.; Ball S.; Baringer P.; Bean A.; Besson D.; Coppage D.; Copty N.; Davis R.; Hancock N.; Kelly M.; Kotov S.; Kravchenko I.; Kwak N.; Lam H.; Kubota Y.; Lattery M.; Momayezi M.; Nelson J.; Patton S.; Perticone D.; Poling R.; Savinov V.; Schrenk S.; Wang R.; Alam M.; Kim I.; Nemati B.; Ling Z.; O'Neill J.; Severini H.; Sun C.; Wappler F.; Crawford G.; Daubenmier C.; Fulton R.; Fujino D.; Gan K.; Honscheid K.; Kagan H.; Kass R.; Lee J.; Malchow R.; Skovpen Y.; Sung M.; White C.; Zoeller M.; Butler F.; Fu X.; Kalbfleisch G.; Ross W.; Skubic P.; Wood M.; Fast J.; Mcilwain R.; Miao T.; Miller D.; Modesitt M.; Payne D.; Shibata E.; Shipsey I.; Wang P.; Battle M.; Ernst J.; Gibbons L.; Kwon Y.; Roberts S.; Thorndike E.; Wang C.; Dominick J.; Lambrecht M.; Sanghera S.; Shelkov V.; Skwarnicki T.; Stroynowski R.; Volobouev I.; Wei G.; Zadorozhny P.; Artuso M.; Goldberg M.; He D.; Horwitz N.; Kennett R.; Mountain R.; Moneti G.; Muheim F.; Mukhin Y.; Playfer S.; Rozen Y.; Stone S.; Thulasidas M.; Vasseur G.; Xing X.; Zhu G.; Bartelt J.; Csorna S.; Egyed Z.; Jain V.; Gibaut D.; Kinoshita K.; Kinoshita K.; Barish B
1ST MEASUREMENT OF GAMMA(D(S)(+)-]MU+NU)/GAMMA(D(S)(+)-]PHI-PI+)
No full textComplete Author List:
ACOSTA D, ATHANAS M, MASEK G, PAAR H, BEAN A, GRONBERG J, KUTSCHKE R, MENARY S, MORRISON RJ, NAKANISHI S, NELSON HN, NELSON TK, RICHMAN JD, RYD A, TAJIMA H, SCHMIDT D, SPERKA D, WITHERELL MS, PROCARIO M, YANG S, BALEST R, CHO K, DAOUDI M, FORD WT, JOHNSON DR, LINGEL K, LOHNER M, RANKIN P, SMITH JG, ALEXANDER JP, BEBEK C, BERKELMAN K, BESSON D, BROWDER TE, CASSEL DG, CHO HA, COFFMAN DM, DRELL PS, EHRLICH R, GALIK RS, GARCIASCIVERES M, GEISER B, GITTELMAN B, GRAY SW, HARTILL DL, HELTSLEY BK, JONES CD, JONES SL, KANDASWAMY J, KATAYAMA N, KIM PC, KREINICK DL, LUDWIG GS, MASUI J, MEVISSEN J, MISTRY NB, NG CR, NORDBERG E, OGG M, PATTERSON JR, PETERSON D, RILEY D, SALMAN S, SAPPER M, WORDEN H, WURTHWEIN F, AVERY P, FREYBERGER A, RODRIGUEZ J, STEPHENS R, YELTON J, CINABRO D, HENDERSON S, KINOSHITA K, LIU T, SAULNIER M, SHEN F, WILSON R, YAMAMOTO H, ONG B, SELEN M, SADOFF AJ, AMMAR R, BALL S, BARINGER P, COPPAGE D, COPTY N, DAVIS R, HANCOCK N, KELLY M, KWAK N, LAM H, KUBOTA Y, LATTERY M, NELSON JK, PATTON S, PERTICONE D, POLING R, SAVINOV V, SCHRENK S, WANG R, ALAM MS, KIM IJ, NEMATI B, ONEILL JJ, SEVERINI H, SUN CR, ZOELLER MM, CRAWFORD G, DAUBENMIER CM, FULTON R, FUJINO D, GAN KK, HONSCHEID K, KAGAN H, KASS R, LEE J, MALCHOW R, MORROW F, SKOVPEN Y, SUNG M, WHITE C, WHITMORE J, WILSON P, BUTLER F, FU X, KALBFLEISCH G, LAMBRECHT M, ROSS WR, SKUBIC P, SNOW J, WANG PL, WOOD M, BORTOLETTO D, BROWN DN, FAST J, MCILWAIN RL, MIAO T, MILLER DH, MODESITT M, SCHAFFNER SF, SHIBATA EI, SHIPSEY IPJ, WANG PN, BATTLE M, ERNST J, KROHA H, ROBERTS S, SPARKS K, THORNDIKE EH, WANG CH, DOMINICK J, SANGHERA S, SHELKOV V, SKWARNICKI T, STROYNOWSKI R, VOLOBOUEV I, ZADOROZHNY P, ARTUSO M, HE D, GOLDBERG M, HORWITZ N, KENNETT R, MONETI GC, MUHEIM F, MUKHIN Y, PLAYFER S, ROZEN Y, STONE S, THULASIDAS M, VASSEUR G, ZHU G, BARTELT J, CSORNA SE, EGYED Z, JAIN V, SHELDON P, AKERIB DS, BARISH B, CHADHA M, CHAN S, COWEN DF, EIGEN G, MILLER JS, OGRADY C, URHEIM J, WEINSTEIN A
Achieving the Millennium Development Goals: does mental health play a role?
No full textMiranda and Patel argue that mental disorders are among the most important causes of disability and premature mortality in developing countries
Precision measurement of the Ds*+-Ds+ mass difference
No full textcomplete author list: Brown D.; Fast J.; McIlwain R.; Miao T.; Miller D.; Modesitt M.; Payne D.; Shibata E.; Shipsey I.; Wang P.; Battle M.; Ernst J.; Kwon Y.; Roberts S.; Thorndike E.; Wang C.; Dominick J.; Lambrecht M.; Sanghera S.; Shelkov V.; Skwarnicki T.; Stroynowski R.; Volobouev I.; Wei G.; Zadorozhny P.; Artuso M.; Goldberg M.; He D.; Horwitz N.; Kennett R.; Mountain R.; Moneti G.; Muheim F.; Mukhin Y.; Playfer S.; Rozen Y.; Stone S.; Thulasidas M.; Vasseur G.; Zhu G.; Bartelt J.; Csorna S.; Egyed Z.; Jain V.; Kinoshita K.; Edwards K.; Ogg M.; Britton D.; Hyatt E.; MacFarlane D.; Patel P.; Akerib D.; Barish B.; Chadha M.; Chan S.; Cowen D.; Eigen G.; Miller J.; O'Grady C.; Urheim J.; Weinstein A.; Acosta D.; Athanas M.; Masek G.; Paar H.; Gronberg J.; Kutschke R.; Menary S.; Morrison R.; Nakanishi S.; Nelson H.; Nelson T.; Qiao C.; Richman J.; Ryd A.; Tajima H.; Sperka D.; Witherell M.; Procario M.; Balest R.; Cho K.; Daoudi M.; Ford W.; Johnson D.; Lingel K.; Lohner M.; Rankin P.; Smith J.; Alexander J.; Bebek C.; Berkelman K.; Bloom K.; Browder T.; Cassel D.; Cho H.; Coffman D.; Drell P.; Ehrlich R.; Gaiderev P.; Garcia-Sciveres M.; Geiser B.; Gittelman B.; Gray S.; Hartill D.; Heltsley B.; Jones C.; Jones S.; Kandaswamy J.; Katayama N.; Kim P.; Kreinick D.; Ludwig G.; Masui J.; Mevissen J.; Mistry N.; Ng C.; Nordberg E.; Patterson J.; Peterson D.; Riley D.; Salman S.; Sapper M.; Würthwein F.; Avery P.; Freyberger A.; Rodriguez J.; Stephens R.; Yang S.; Yelton J.; Cinabro D.; Henderson S.; Liu T.; Saulnier M.; Wilson R.; Yamamoto H.; Bergfeld T.; Eisenstein B.; Gollin G.; Ong B.; Palmer M.; Selen M.; Thaler J.; Sadoff A.; Ammar R.; Ball S.; Baringer P.; Bean A.; Besson D.; Coppage D.; Copty N.; Davis R.; Hancock N.; Kelly M.; Kwak N.; Lam H.; Kubota Y.; Lattery M.; Nelson J.; Patton S.; Peritcone D.; Poling R.; Savinov V.; Schrenk S.; Wang R.; Alam M.; Kim I.; Nemati B.; O'Neill J.; Severini H.; Sun C.; Zoeller M.; Crawford G.; Daubenmier C.; Fulton R.; Fujino D.; Gan K.; Honscheid K.; Kagan H.; Kass R.; Lee J.; Malchow R.; Skovpen Y.; Sung M.; White C.; Butler F.; Fu X.; Kalbfleisch G.; Ross W.; Skubic P.; Snow J.; Wang P.; Wood M.; Brown D.; Skubic P.; Snow J.; Wang P.; Wood M.; Butler F.; Fu X.; Kalbfleisch G.; Ross W.; Brown D.N.</p
1,25-dihydroxyvitamin D3 and development of tuberculosis in cattle
No full textThis report describes the presence and activity of 1,25-dihydroxyvitamin D3 (1,25-D3) in experimental bovine tuberculosis. Animals that went on to develop tuberculous lesions exhibited a rapid transient increase in serum 1,25-D3 within the first 2 weeks following infection with Mycobacterium bovis. 1,25-D3-positive mononuclear cells were later identified in all tuberculous granulomas by immunohistochemical staining of postmortem lymph node tissue. These results suggest a role for 1,25-D3 both at the onset of infection and in the development of the granuloma in these infected animals. Using a monoclonal antibody to the vitamin D receptor (VDR) as a VDR agonist, we confirmed that activation of the vitamin D pathway profoundly depresses antigen-specific, but not mitogenic, bovine peripheral blood T-cell responses (proliferation and gamma interferon production). Investigation of the mechanism of this suppression showed that the VDR antibody modified the expression of CD80 by accessory cells, such that a significant positive correlation between T-cell proliferation and accessory cell CD80 emerged
Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity
No full textG-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome. In particular, they have been proposed to be directly involved in gene regulation at the level of transcription. Because the HIV-1 Nef protein is a fundamental factor for efficient viral replication, infectivity and pathogenesis in vitro and in vivo, we investigated G-quadruplex formation in the HIV-1 nef gene to assess the potential for viral inhibition through G-quadruplex stabilization. A comprehensive computational analysis of the nef coding region of available strains showed the presence of three conserved sequences that were uniquely clustered. Biophysical testing proved that G-quadruplex conformations were efficiently stabilized or induced by G-quadruplex ligands in all three sequences. Upon incubation with a G-quadruplex ligand, Nef expression was reduced in a reporter gene assay and Nef-dependent enhancement of HIV-1 infectivity was significantly repressed in an antiviral assay. These data constitute the first evidence of the possibility to regulate HIV-1 gene expression and infectivity through G-quadruplex targeting and therefore open a new avenue for viral treatment. © 2013 Perrone et al
- …
