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Sorveglianza aerobiologica in L’Aquila: triennio 1993-95. Incontro di aggiornamento della Società Italiana di Allergologia ed Immunologia Clinica
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PRODUZIONE DI IL-6 PARTE DELLE CELLULE MONONUCLEATE DEL SANGUE PEROFERICO IN PAZIENTI AFFETTI DA SCLEROSI SISTEMICA PROGRESSIVA (SSP)
No full textT lymphocytes in the synovial fluid of patients with active rheumatoid arthritis display CD134-OX40 surface antigen.
No full textL'ITS riduce i livelli sierici di CD30 solubile (sCD30) in pazienti con allergia a veleno d' ape
No full textEffects of interferon ß, cyclophosphamide, and azathioprine on cytokine profile of patients with multiple sclerosis
No full textWe assessed the in vitro effects of interferon beta-1b (IFNβ-1b), cyclophosphamide (CY), and azathioprine (AZA) alone and of the combination of IFNβ-1b with CY or AZA on the production of Th1 and Th2 cytokines in 10 patients with multiple sclerosis. Cytokine levels were determined at baseline and after stimulation with IFNβ-1b, CY, and AZA alone or with the combination of IFNβ-1b with CY or AZA. The combination of IFNβ-1b with CY resulted in a statistically significant decrease in the production of interleukin-2 (IL-2) (P=0.003) and tumor necrosis factor alfa (TNFα) (P=0.03). An additive effect on the production of interferon gamma (IFN-γ) (P=0.2) and interleukin-10 (IL-10) (P=0.6), and a positive interaction on the production of interleukin-4 (IL-4) (P=0.08) were observed although the findings were not statistically significant. The combination of IFNβ-1b with AZA resulted in a significant negative effect on the production of IL-2 (P=0.006), whereas TNF-α (P=0.02), IFN-γ (P=0.03), IL-4 (P=0.2), and IL-10 (P=0.3) were not statistically impacted. Our data show that CY was able to improve the effects of IFNβ-1b on the ratio of Th1/Th2 cytokines
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