1,721,176 research outputs found
Author response to: Survival after active surveillance versus upfront surgery for incidental small pancreatic neuroendocrine tumours
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Non functional pancreatic neuroendocrine tumors
No full textNonfunctioning Pancreatic Neuroendocrine Neoplasia (NF-PanNEN) are a wide group of heterogeneous tumors, increasingly diagnosed in recent years. NF-PanNEN are classified in different categories based on Ki67 proliferation index and their morphology (well differentiated PanNEN, poorly differentiated pancreatic neuroendocrine carcinoma and mixed neuroendocrine-non neuroendocrine neoplasia). Preoperative evaluation of NF-PanNEN consists of both conventional morphological radiological examination and functional imaging. Treatment depends on several factors such as stage, patient characteristics, and aggressiveness of disease. Surgical management of NF-PanNEN is highly variable ranging from observation for small asymptomatic lesions to multivisceral resection in advanced forms. A multidisciplinary tailored approach is always recommended for choosing the best management in patients affected by NF-PanNEN
Pancreatic cancer
No full textPancreatic cancer is the fourth leading cause of death for neoplasm in western countries. Surgery still remains the treatment of choice although almost 80% of patients are not resectable at diagnosis because of liver metastases and the 5-year overall survival of patients treated with surgery is only (20%). During the last two decades we have witnessed an overall improvement in terms of survival, mostly due to the advances in therapy and strategies for a more accurate patient selection for surgery. Specific preoperative criteria, mostly linked to the biological features of the tumour, have been proposed to better identify those patients who will benefit from surgical resection, such as duration of symptoms and serum level of CA19-9 in resectable disease. Oncological therapy plays a central role in the management of pancreatic cancer. In patients undergone surgical resection, adjuvant therapy might increase the overall survival and reduce the rate of early relapse. Patients with locally advanced pancreatic cancer can be treated with neoadjuvant treatment. Chemotherapy or chemoradiotherapy are usually used with the aim to downstage the disease but whether one specific strategy or drug is the treatment of choice is still under debate
Diagnosis and Treatment of Pancreatic Neuroendocrine Tumors: How to Deal with them in Clinical Practice?
No full textPig Xenotransplantation in Beta Cell Replacement: Addressing Challenges and Harnessing Potential for Type 1 Diabetes Therapy
Full text linkThis opinion paper evaluates the potential of porcine islets as a promising alternative in beta cell replacement therapy for Type 1 Diabetes (T1D), juxtaposed with the current limitations of human donor islets. It analyzes the compatibility of pig islets with human glucose metabolism, their prospects as a limitless and high-quality source of beta cells, and the unique immunogenic challenges they present in xenotransplantation. Additionally, the paper discusses the regulatory and ethical considerations pertinent to the use of porcine islets. By synthesizing current research and expert perspectives, the paper highlights both the opportunities and significant barriers that need addressing to advance pig islets as a viable therapeutic option. The findings advocate for a balanced and forward-looking approach to the integration of pig islets in T1D treatment, underscoring the need for continued research and dialogue in this evolving field
The natural history of a branch-duct intraductal papillary mucinous neoplasm of the pancreas.
No full textThe natural history of a branch-duct intraductal papillary mucinous neoplasm of the pancreas.
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