591 research outputs found
Rich Dad Poor Dad: An Entrepreneurial Approach to the Teaching of Business French
No full textUS higher education has focused on the development of new cadres of employees to the near exclusion of entrepreneurship as a career path. In this article, the authors describe an entrepreneurial approach to the teaching of Business French. The senior author served as the course instructor while the junior author was a student who completed the course. To provide an entry into the world of global entrepreneurship, the senior author selected the French translation of Robert Kiyosaki’s Rich Dad Poor Dad. In parallel with the reading of Rich Dad, students completed a series of entrepreneurial course activities. Selected activities are described from the perspectives of both authors. The article ends with students’ feelings about (1) entrepreneurship, (2) future career plans, (3) the theme of the course, and (4) the use of Kiyosaki’s Rich Dad Poor Dad
In vivo and in vitro evidence that the four essential intermediate filament (IF) proteins A1, A2, A3 and B1 of the nematode Caenorhabditis elegans form an obligate heteropolymeric IF system
No full textThe in vitro polymerization and tissue-specific expression patterns of the four essential intermediate filament (IF) proteins (A1, A2, A3, B1) and the non-essential IF protein A4 were analyzed. Recombinant B1, used as a probe in blot overlay assays of the 11 Caenorhabditis elegans IF proteins, reacted strongly with proteins A1 to A4, indicating a heterotypic interaction. Obligate heteropolymeric filament assembly in vitro was confirmed by electron microscopy. Protein B1 formed long IF when mixed with an equimolar amount of A1, A2 or A3. Developmentally regulated coexpression of 131 and one or more members of the A family was found with GFP-promoter reporters. This coexpression pattern argues for a heteropolymer system in vivo. One or both splice variants of the B1 gene are always coexpressed in a tissue-specific manner with at least one member of the A family in hypodermis, pharynx, pharyngeal-intestinal valve, excretory cells, uterus, vulva and rectum. Interestingly, while the intestine normally lacks a B1/A pair, the dauer larva shows intestinal B1 and A4. These results are in line with similar postembryonic phenotypes of the hypodermis induced by RNA interference (RNAi) of genes B1, A2 and A3. Similarly, defects of the pharynx and its A1-GFP containing tonofilaments observed in the postembryonic B1 RNAi phenotype are consistent with the coexpression of B1 and A1 in the marginal cells. Thus RNAi analyses provide independent evidence for the existence of the B1/A obligate heteropolymer system in vivo. Proteins A1 and B1 have a similar and rather slow turnover rate in photobleaching experiments of the pharynx tonofilaments. (C) 2003 Published by Elsevier Ltd
50 Years of the steric-blocking mechanism in vertebrate skeletal muscle: a retrospective
No full textFifty years have now passed since Parry and Squire proposed a detailed structural model that explained how tropomyosin, mediated by troponin, played a steric-blocking role in the regulation of vertebrate skeletal muscle. In this Special Issue dedicated to the memory of John Squire it is an opportune time to look back on this research and to appreciate John’s key contributions. A review is also presented of a selection of the developments and insights into muscle regulation that have occurred in the years since this proposal was formulated
Structures of the ß-Keratin Filaments and Keratin Intermediate Filaments in the Epidermal Appendages of Birds and Reptiles (Sauropsids)
No full textThe epidermal appendages of birds and reptiles (the sauropsids) include claws, scales, and feathers. Each has specialized physical properties that facilitate movement, thermal insulation, defence mechanisms, and/or the catching of prey. The mechanical attributes of each of these appendages originate from its fibril-matrix texture, where the two filamentous structures present, i.e., the corneous ß-proteins (CBP or ß-keratins) that form 3.4 nm diameter filaments and the α-fibrous molecules that form the 7–10 nm diameter keratin intermediate filaments (KIF), provide much of the required tensile properties. The matrix, which is composed of the terminal domains of the KIF molecules and the proteins of the epidermal differentiation complex (EDC) (and which include the terminal domains of the CBP), provides the appendages, with their ability to resist compression and torsion. Only by knowing the detailed structures of the individual components and the manner in which they interact with one another will a full understanding be gained of the physical properties of the tissues as a whole. Towards that end, newly-derived aspects of the detailed conformations of the two filamentous structures will be discussed and then placed in the context of former knowledge
Pete Pock-A-Doo and Beverly, Too : Memoirs of a Dad and Daughter
No full textxii, 64 p.The author creates a work of autobiographical fiction inspired by works by Scott Momaday and Sandra Cisneros that intersperses audio recordings of her father with her own memoir. In her introduction, the author describes her father’s cancer diagnosis when she was younger and his more recent struggle with kidney failure. She writes, “In the simplest terms, this is a memoir about me and my dad. It is the result of a search for clarity, but first, a clarification: My dad is not a cancer patient. I try to think of him instead as a man charged with the task of carrying an extra load, and although God isn't a name we throw around the house very much anymore, he believes that's who gave it to him. This project began when God chose to make that load a little heavier for several months during my last two years of college.
DAD-match; Security technique to prevent denial of service attack on duplicate address detection process in IPv6 link-local network.
No full textAn efficiently unlimited address space is provided by Internet Protocol version 6 (IPv6). It aims to accommodate thousands of hundreds of unique devices on a similar link. This can be achieved through the Duplicate Address Detection (DAD) process. It is considered one of the core IPv6 network's functions. It is implemented to make sure that IP addresses do not conflict with each other on the same link. However, IPv6 design's functions are exposed to security threats like the DAD process, which is vulnerable to Denial of Service (DoS) attack. Such a threat prevents the host from configuring its IP address by responding to each Neighbor Solicitation (NS) through fake Neighbor Advertisement (NA). Various mechanisms have been proposed to secure the IPv6 DAD procedure. The proposed mechanisms, however, suffer from complexity, high processing time, and the consumption of more resources. The experiments-based findings revealed that all the existing mechanisms had failed to secure the IPv6 DAD process. Therefore, DAD-match security technique is proposed in this study to efficiently secure the DAD process consuming less processing time. DAD-match is built based on SHA-3 to hide the exchange tentative IP among hosts throughout the process of DAD in an IPv6 link-local network. The obtained experimental results demonstrated that the DAD-match security technique achieved less processing time compared with the existing mechanisms as it can resist a range of different threats like collision and brute-force attacks. The findings concluded that the DAD-match technique effectively prevents the DoS attack during the DAD process. The DAD-match technique is implemented on a small area IPv6 network; hence, the author future work is to implement and test the DAD-match technique on a large area IPv6 network
Toxicity mechanism of anthropogenic water contaminants: drinking water disinfection by-products (haloacetic acids) and particle associated contaminants from sealcoats (polyaromatic hydrocarbons) in lake sediments
No full textDrinking water disinfection was one of the major public health accomplishments of 20th century. Water disinfection helps in reducing waterborne diseases like typhoid fever, cholera, and hepatitis A. However, chemical water disinfection also produces unwanted toxic chemicals, known as water disinfection by-products (DBPs). Most of the DBPs are cytotoxic, neurotoxic, genotoxic, mutagenic, carcinogenic and teratogenic but the toxicity mechanism is not completely understood. Therefore, the objectives of this dissertation were to i) understand the toxicity mechanisms and identify the molecular targets of all the regulated and non-regulated haloacetic acids (HAAs) water DBPs, ii) to differentiate among the toxicity mechanisms of mono-, di-, and triHAAs, iii) to evaluate the toxicity potential of chlorinated and chloraminated wastewater effluents, and iv) to evaluate the mutagenicity potential of the particle associated contaminants such as polyaromatic hydrocarbons (PAHs) associated with coal tar and soot, extracted from lake core sediments.
Studies based on the toxicity mechanism of HAAs water DBPs demonstrated that monoHAAs were the strongest inhibitors of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) where, di-, and triHAAs were weaker inhibitors. MonoHAAs greatly reduced the ATP contents of the cells. Unlike monoHAAs, triHAAs increased the cellular ATP levels as compared to the negative controls. Exogenous pyruvate supplementation rescued cells from monoHAA-induced DNA damage and ATP depletion. These results confirmed that monoHAA-induced genotoxicity was due to GAPDH inhibition. HAAs not only affected the GAPDH kinetics and disturbed the cellular energy homeostasis but also increased pyruvate dehydrogenase complex (PDC) activity. Increased PDC activity by monoHAAs was due to changes in metabolite ratios e.g., ATP/ADP, and NADH/NAD ratio but the increase induced by di-, and triHAAs was due to the inhibition of pyruvate dehydrogenase kinase (PDK). Results demonstrated that HAA-induced toxicity is due to disruption in cellular energy homeostasis. This research demonstrated that there was a difference among the HAA-induced toxicity mechanisms and their molecular targets. MonoHAAs had an indirect effect on mitochondrial metabolism by inhibiting GAPDH, affecting the generation of pyruvate, inducing oxidative stress and reducing the final output of mitochondria in the form of ATP. Among monoHAAs, the rank order of toxicity was iodoacetic acid > bromoacetic acid >> chloroacetic acid (IAA > BAA >> CAA). This toxicity pattern was directly correlated with the inhibition of GAPDH kinetics, ATP depletion, and PDC activation. Whereas, di- and triHAAs induced toxicity by directly affecting mitochondrial metabolism by PDK inhibition, which led to PDC activation.
The toxicity potential of chlorinated and chloraminated wastewater effluents extracted with XAD-8 and XAD-4 resins was evaluated. For chlorinated water, the organic extracts eluted from XAD-8 were more cytotoxic than that of the chloraminated wastewater extracts. However, the XAD-4 extracts of the chlorinated wastewaters and chloraminated wastewaters did not show any significance difference. Unlike the cytotoxicity analyses, the chloraminated wastewater XAD-8 extracts showed a higher genotoxic effect in mammalian cells than the XAD-4 extracts. Thus the major cytotoxicity and genotoxicity components in wastewater effluents were associated with hydrophobic acid fractions as compared to the transphilic acid fractions.
The mutagenicity evaluation of the coal tar and soot associated polyaromatic hydrocarbons (PAHs) from lake sediments demonstrated that the coal tar and soot extracts were not direct acting mutagens but needed S9 microsomal activation. It was also found that coal tar extracts induced a higher rate of base pair substitution mutations as compared to the induction of frameshift mutations. Soot extracts induced a relatively higher rate of frameshift mutations as compared to the coal tar extract frameshift mutation rate.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-12-01The student, Azra Dad, accepted the attached license on 2016-08-01 at 18:20.The student, Azra Dad, submitted this Dissertation for approval on 2016-08-01 at 21:48.This Dissertation was approved for publication on 2016-11-07 at 15:18.DSpace SAF Submission Ingestion Package generated from Vireo submission #10097 on 2017-02-28 at 14:35:47Made available in DSpace on 2017-03-01T16:36:36Z (GMT). No. of bitstreams: 2
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Previous issue date: 2016-11-07Embargo set by: Seth Robbins for item 98561
Lift date: 2019-03-01T16:37:19Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 98561 on 2019-03-02T10:15:27Z
Love and Fond Kisses to Dear Dad from Home
No full text(Black and White) This postcard is a real photograph of two hands clasped underneath Allied countries' flags and surrounded by roses. The text, by Terry, is also surrounded by roses. The border is a bas relief floral pattern. There if no stamp or postmark. Like "To my Dear Daddy" and "A Message to my Hero," the postcard is addressed to Lieutenant Corporal Etherington, and from the same writer as "To my dear Daddy," his daughter.This collection previously belonged to Dominic Hibberd, an English biographer most noted for the biographies of Wilfred Owen and Harold Monro, World War I poets. He collected these postcards for research purposes.TRANSCRIPTION; MESSAGE: To Dear Dad; with Love from Gladys; x; SENT TO: 1642 Lei Cpl Etheringto
CARA BERPIKIR ORANG MISKIN MENURUT BUKU RICH DAD POOR DAD SEBAGAI GAGASAN BERKARYA SENI PATUNG
No full textKemiskinan merupakan masalah yang selalu aktual terutama di negara berkembang seperti Indonesia. Fenomena orang kaya semakin kaya dan orang miskin semakin miskin seringkali terjadi. Penyebab kemiskinan juga sangat kompleks, salah satunya adalah cara berpikir mereka tentang keuangan. Dalam buku Rich Dad Poor Dad sedikit banyaknya telah diuraikan perbedaan orang miskin dan orang kaya dalam cara mereka berpikir, hal ini beberapa sesuai dengan yang dialami penulis. Karya ini bertujuan untuk mewujudkan isu dan fenomena tersebut. Penggayaan patung dengan mengadopsi gaya arsitektur brutalism memiliki kecocokan dengan gagasan ini. Metode yang digunakan pada penciptaan karya ini adalah metode Research in the Arts, dimana seluruh rangkaian penciptaan dilakukan oleh penulis itu sendiri. Penciptaan karya ini melalui beberapa tahapan sebagai proses kreatif mulai dari pra ide, stimulus, ide, pengumpulan data pengolahan ide, proses pembuatan karya, hasil karya, evaluasi karya, pengemasan karya dan penyajian karya. Material yang dipilih melalui berbagai studi teknik dan bahan disesuaikan dengan teknik yang digunakan untuk menunjang penciptaan. Subject matter utama pada patung ini adalah perwujudan kolom bangunan kasar warna monochrome dominan abu-abu alami dari materialnya sendiri yang dilengkapi dengan objek berwarna putih sebagai kontras pada setiap patung. Karya patung yang diwujudkan berjumlah lima buah secara keseluruhan gagasan patung ini mengangkat cara pikir miskin menurut R. T. Kiyosaki Penggayaan patung dengan meminjam gaya arsitektur brutalism menjadi daya tarik tersendiri dalam dunia seni yang kian hari kian bebas, hal ini dapat memperkaya wacana kesenirupaan terutama pada masa kontemporer ini.
Poverty is an issue that remains highly relevant, especially in developing countries such as Indonesia. The phenomenon of the rich becoming richer and the poor becoming poorer frequently occurs. The causes of poverty are also highly complex, one of which is the way people think about finance. In the book Rich Dad Poor Dad, Robert T. Kiyosaki outlines, to some extent, the differences between the mindset of the poor and the rich, several of which align with the author’s own experiences. This work aims to manifest these issues and phenomena. The stylistic choice of adopting Brutalist architectural elements in sculpture is considered compatible with this idea. The method employed in this creation is Research in the Arts, where the entire creative process is carried out by the author. The process involves several stages, including pre-idea, stimulus, idea development, data collection, idea processing, artwork production, evaluation, packaging, and presentation. The selection of materials is based on technical and material studies, adjusted to the techniques applied to support the creation process. The main subject matter of these sculptures is the embodiment of rough architectural columns in natural monochrome gray, inherent to the material itself, combined with white objects as contrasting elements in each sculpture. A total of five sculptures were created, collectively representing the mindset of the poor as described by R. T. Kiyosaki. The adoption of Brutalist architecture as a stylistic approach adds a distinctive appeal to the contemporary art scene, enriching discourses in fine arts in today’s increasingly open artistic landscape
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