19 research outputs found
“Educator and Civilizer”: The Woman’s Home Missionary Society of the Methodist Episcopal Church and the Education of Indigenous Alaskans
No full textExecutable clinical models for acute care
No full textMedical errors are the third leading cause of death in the U.S., after heart disease and cancer, causing at least 250,000 deaths every year. These errors are often caused by slips and lapses, which include, but are not limited to delayed diagnosis, delayed or ineffective therapeutic interventions, and unintended deviation from the best practice guidelines. These situations may occur more often in acute care settings, where the staff are overloaded, under stress, and must make quick decisions based on the best available evidence. An \textit{integrated clinical guidance system} can reduce such medical errors by helping medical staff track and assess patient state more accurately and adapt the care plan according to the best practice guidelines.
However, a main prerequisite for developing a guideline system is to create computer interpretable representations of the clinical knowledge. The main focus of this thesis is to develop executable clinical models for acute care. We propose an organ-centric pathophysiology-based modeling paradigm, in which we translate the medical text into executable interactive disease and organ state machines. We formally verify the correctness and safety of the developed models. Afterward, we integrate the models into a best practice guidance system. We study the cardiac arrest and sepsis case studies to demonstrate the applicability of proposed modeling paradigm. We validate the clinical correctness and usefulness of our model-driven cardiac arrest guidance system in an ACLS training class. We have also conducted a preliminary clinical simulation of our model-driven sepsis screening system.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-05-01The student, Maryam Rahmaniheris, accepted the attached license on 2017-04-14 at 16:31.The student, Maryam Rahmaniheris, submitted this Dissertation for approval on 2017-04-14 at 16:45.This Dissertation was approved for publication on 2017-04-17 at 11:00.DSpace SAF Submission Ingestion Package generated from Vireo submission #10769 on 2017-08-10 at 14:30:43Made available in DSpace on 2017-08-10T19:51:56Z (GMT). No. of bitstreams: 3
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Previous issue date: 2017-04-17Embargo set by: Colleen Fallaw for item 102624
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The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression
No full textExamined immune-deficiency markers, i.e., serum interleukin-6 (IL-6), IL-8, IL-6 receptor (IL-6R), IL-1R antagonist (IL1RA), gp130, and prostaglandin E2 (PGE2) production by mitogen-stimulated whole blood and the availability of plasma tryptophan in 10 patients with primary sleep disorders, 6 patients with major depression, and 14 healthy volunteers
Cerebral atrophy in mild cognitive impairment and Alzheimer disease: rates and acceleration.
No full textOBJECTIVE: To quantify the regional and global cerebral atrophy rates and assess acceleration rates in healthy controls, subjects with mild cognitive impairment (MCI), and subjects with mild Alzheimer disease (AD). METHODS: Using 0-, 6-, 12-, 18-, 24-, and 36-month MRI scans of controls and subjects with MCI and AD from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, we calculated volume change of whole brain, hippocampus, and ventricles between all pairs of scans using the boundary shift integral. RESULTS: We found no evidence of acceleration in whole-brain atrophy rates in any group. There was evidence that hippocampal atrophy rates in MCI subjects accelerate by 0.22%/year2 on average (p = 0.037). There was evidence of acceleration in rates of ventricular enlargement in subjects with MCI (p = 0.001) and AD (p < 0.001), with rates estimated to increase by 0.27 mL/year2 (95% confidence interval 0.12, 0.43) and 0.88 mL/year2 (95% confidence interval 0.47, 1.29), respectively. A post hoc analysis suggested that the acceleration of hippocampal loss in MCI subjects was mainly driven by the MCI subjects that were observed to progress to clinical AD within 3 years of baseline, with this group showing hippocampal atrophy rate acceleration of 0.50%/year2 (p = 0.003). CONCLUSIONS: The small acceleration rates suggest a long period of transition to the pathologic losses seen in clinical AD. The acceleration in hippocampal atrophy rates in MCI subjects in the ADNI seems to be driven by those MCI subjects who concurrently progressed to a clinical diagnosis of AD
Monetary theory and monetary policy : reflections on the development over the last 150 years
No full textIn this paper, we provide some reflections on the development of monetary theory and monetary policy over the last 150 years. Rather than presenting an encompassing overview, which would be overambitious, we simply concentrate on a few selected aspects that we view as milestones in the development of this subject. We also try to illustrate some of the interactions with the political and financial system, academic discussion and the views and actions of central banks
Monetary theory and monetary policy : reflections on the development over the last 150 years : [Version 8 Dezember 2012]
No full textIn this paper, we provide some reflections on the development of monetary theory and monetary policy over the last 150 years. Rather than presenting an encompassing overview, which would be overambitious, we simply concentrate on a few selected aspects that we view as milestones in the development of this subject. We also try to illustrate some of the interactions with the political and financial system, academic discussion and the views and actions of central banks
The radical potential of student voice: Creating spaces for restless encounters
No full textThis paper starts by sketching out some of the developments in research partnerships between adults and young people within the context of formal schooling in the last twenty years and then briefly touches on some of the critiques of such work, underlining the role of values and political perspectives. The third section argues for a particular - person-centred - standpoint resting on a relational, communal view of the self that puts certain kinds of relationships at the heart of education and schooling in general, and student voice partnerships in particular. Finally, the author argues for the importance of creating spaces for restless encounters between adults and young people in which they are able to re-see and re-engage with each other in creative, holistic and potentially transformational ways. In taking this forward, the much neglected and derided radical traditions of state education offer us an important resource
ALT-C 2011 Abstracts
No full textThis is a PDF of the abstracts for all the sessions at the 2011 ALT conference. It is designed to be used alongside the online version of the conference programme. It was made public on 1 September, with a "topped and tailed" made live on 2 September
Differential patterns in comparative education discourse
No full textThis dissertation study argues that 'policy advice formation', as a discourse development, is a differentiated hybrid resultant from merger between comparative education and policy studies disciplines. Through discourse analysis based on John Creswell's format, this study identifies revisions, restatements and shifts in emphasis of theories, methodological models and challenge topics of comparative education and policy studies. Findings which display the development of policy advice formation' discourse. In conclusion, this study found differential patterns seemingly formed because of collaborative affects of standardization in education science knowledge expressed within discourse
Overlapping montage: a comparative study of mainstream film and moving-image installations
No full textThis dissertation develops a discussion on the need for a comparative approach to the study of film and moving- image installations. It addresses the lack of critical attention given to moving-image installations within film studies generally and academic teaching programmes in particular. The development of a comparative approach requires researching a number of interlinking and independent fields of study such as film studies, art history/criticism, photography, literary theory, critical theory, anthropology and philosophy. While arguing against traditional disciplinary boundaries, the discussion critiques the accepted articulations of current interdisciplinary approaches.
The dissertation discusses how an expanded field of comparative film studies needs to concern itself with both diachronic and synchronic axes, requiring a longer historical framework to analyse shifts in technologies of representation and related theories of subjectivity within particular capitalist formations. It is argued that this type of comparative model elaborates a more critically productive and conceptually expansive discussion of cultural products, whether they are mainstream film or moving-image installations. As such it aligns itself with an awareness of the political importance of history, memory and personal experience.
The theoretical ground for a comparative approach is developed through exploring montage and fragmentation. While articulating the significance of theories of fragmentation to discussions of modernity and modernism, the thesis foregrounds the significance of understanding all cultural production as ‘montages’ - as elaborations of a number of competing discourses, both when they are made and when they are read. A reconceptualization of montage as a dominant component in cultural meaning making moves away from montage as an aesthetics of form. Rather than understanding film and moving-image installations as rigidly delineated objects, they are explored through hybridity and overlap, for example through the multiple scopic regimes, which shape and form them. In this enterprise, the significance of an anthropological materialist’ approach to cinema and moving-image installations is articulated as a means of developing a critical cognitive engagement with our varied cultural and ever changing social environment
