44 research outputs found
Periampullary carcinoma-a rare histopathological variant
No full textSignet ring cell adenocarcinomas may be encountered in various parts of gastrointestinal tract but are almost unheard of in the region of ampulla of vater. In the region of ampulla of vater even if we come across an adenocarcinoma, it is usually a well differentiated variant. A 56-year-old female with features of obstructive jaundice on evaluation was diagnosed to have a peri-ampullary carcinoma.The patient was subjected to a laparotomy. On exploration patient was found to have a malrotation of gut. Patient was subjected to a pylorus preserving pancreatico-duodenectomy. Histopathology of the resected specimen revealed a signet ring morphology which is a rare variant in periampullary region
Gastrointestinal stromal tumour of pelvic wall: report of a case
No full textGastrointestinal stromal tumors (GIST) because of its rarity continues to be a curiosity for radiologists, surgeons and pathologist. These tumors are usually found in gastrointestinal tract (GIT) but account for less than 1% of GIT tumors. A 35-year-old male presented to us with complaints of painful micturation which on radiologic evaluation revealed a large mass in relation to urinary bladder. The tru-cut biopsy reported a low grade soft tissue tumour. The said mass was excised on laparotomy and sent for histopathological examination which reported as high grade GIST or a pleomorphic sarcoma as possibilities. Immuno-histochemistry finally confirmed the diagnosis of a GIST with CD 34 positive and C-Kit negative status. Approximately, 95% of GIST tumors are C-Kit positive and hardly 5% are C-Kit negative. C-Kit negative status makes this case report more worth reporting
Ulcerative Colitis: A Challenge to Surgeons
No full textUlcerative colitis is a chronic disease that specifically affects the mucosa of the rectum and colon. Although the etiology of this recurring inflammatory disorder remains essentially unknown, there have been significant advances in identifying the likely genetic and environmental factors that contribute to its pathogenesis. The clinical course of the disease typically manifests with remissions and exacerbations characterized by rectal bleeding and diarrhea. Since ulcerative colitis most commonly affects patients in their youth or early middle age, the disease can have serious long-term local and systemic consequences. There is no specific medical therapy that is curative. Although medical therapy can ameliorate the inflammatory process and control most symptomatic flares, it provides no definitive treatment for the disease. Proctocolectomy or total removal of the colon and rectum provides the only complete cure; however, innovative surgical alternatives have eliminated the need for a permanent ileostomy. The aim of this review is to provide a detailed account of the surgical management of ulcerative colitis
