162,514 research outputs found
sj-pdf-1-asr-10.1177_00031224211054808 – Supplemental material for Pathways toward Inclusive Income Growth: A Comparative Decomposition of National Growth Profiles
No full textSupplemental material, sj-pdf-1-asr-10.1177_00031224211054808 for Pathways toward Inclusive Income Growth: A Comparative Decomposition of National Growth Profiles by Zachary J. Parolin and Janet C. Gornick in American Sociological Review</p
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
A defective HIV-1 vector for gene transfer to human lymphocytes.
No full textSomatic cell gene therapy is a rapidly evolving appraoch for the treatment of genetic disorders, cancer and infectious diseases.
Retrovirus-mediated gene tranfer is currently the method of choice for human gene therapy trials, since it provides a high efficiency of gene transfer into replicating cells, stable integration of the transfered gene into the host genome, low copy number, and high levels of expression.
Here we report on the feasability of the use of a human immunodeficiency virus type 1 vector for ex-vivo gene transfer to human lymphocytes
Administrative Burdens and Economic Insecurity Among Black, Latino, and White Families
No full textThis study investigates how administrative burdens influence differential receipt of income transfers after a family member loses a job. Using the panel component of the Current Population Survey from 1990 through 2019, we find that administrative burdens have increased in the Temporary Assistance for Needy Families and Unemployment Insurance programs but declined for the Supplemental Nutrition Assistance Program. These administrative burden effects generally contribute to lower income replacement rates for Black and Latino families experiencing job loss relative to White families, though results are sensitive to adjustments for benefit underreporting. Moreover, states with higher shares of White residents have smaller administrative burden effects, on average. Reducing administrative burdens in income transfer programs would likely reduce racial-ethnic inequalities in economic insecurity
Editorial: Metabolomics of Human Microbiome Studies: Recent Advances in Methods and Applications
No full textEditorial on the Research Topic
Metabolomics of Human Microbiome Studies: Recent Advances in Methods and Application
Murder on the mountain: author talk with Peter J. Wosh
No full textAuthor talk by Peter J. Wosh on May 5th, 2022, on his book, "Murder on the Mountain: crime, passion, and punishment in gilded age New Jersey.
Histones post-translational modifications in colon cancer cell line determined by HPLC-ESI-MS and Maldi-Tof for the characterization of deacetylase inhibitors
No full textThe nucleosome is the basic structural unit of eukariotic chromosomes and consists of a DNA molecule associated with a histone octamer comprised of pairs of the core histones H2A, H2B, H3 and H4. Linker DNA and histone1 to form chromatin join the nucleosomes. Histones play an important role in transcription, DNA replication, DNA repair and recombination. Post-translational modifications of specific residues in the core histones (acetylation, methylation, phosphorylation, etc.) have been demonstrated to be critical to their regulatory function. In particular acetylation is a very specific phenomenon with various isoforms playing distinct roles. Increased acetylation is generally correlated with transcriptionally active or poised genes. Histone deacetylases’ inhibitors (short chain fatty acids, such as sodium butyrate, hydroxamic acids such as thrichostatin A) have been described as potential cancer therapeutics in a variety of preclinical studies1. Inhibitors’ treatment of cells resulted in the increase of highly acetylated isoforms of the histones, which affect gene expression, cell differentiation and apoptosis.
It is here described the application of reversed-phase high-pressure liquid chromatography under gradient conditions and mass spectrometry (LC-ESI-MS) to analyse global modification levels of core histones. The LC-MS method was optimised using histones extracted from HT 29 colon cancer cell line2. Histones eluted from the column were detected with Q-Tof and ion trap mass spectrometers with an electrospray source put in parallel and UV detection at 214 nm.
These methods were then applied to the characterisation of changes in histone modification in HT29 treated with histone deacetylase inhibitors such as valproic acid, sodium butyrate and 9-hydroxystearic acid. Acetylation were found located in the H4 histone tail by MALDI-Tof analysis of tryptic and arginase peptide digests.
1Rasheed WK, Johnstone RW, Prince H,Histone deacetylase inhibitors in cancer therapy Expert Opin Investig Drugs. 2007 May;16(5):659-78.
2Naldi M, Andrisano V, Fiori J, Calonghi N, Pagnotta E, Parolin C, Pieraccini G,Masotti L. Histone proteins determined in a human colon cancer by high-performance liquid chromatography and mass spectrometry. J Chromatogr A. 2006 Sep 29;1129(1):73-81
Mr. Melvin J. Collier, RWWL AUC, June 2011
No full textThis video is a conversation with Mr. Melvin J. Collier. Mr. Collier talks about his book, "From Mississippi to Africa: A Journey of Discovery". Daniel Le, AUC Woodruff Library, is the interviewer
A contribution to adequate use of freshwater sponges as a proxy in paleoenvironmental studies
No full textDocio, L., Parolin, M., Pinheiro, U. (2021): A contribution to adequate use of freshwater sponges as a proxy in paleoenvironmental studies. Zootaxa 4915 (4): 506-528, DOI: https://doi.org/10.11646/zootaxa.4915.4.
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