148 research outputs found
An examination of the online student experience and students' online course performance
No full textHematopoietic Stem Cell Transplantation for Myelodysplastic Syndrome
No full textAllogeneic hematopoietic stem cell transplantation remains the only curative option for myelodysplastic syndrome, but patients with this disease are often older and frail, and treatment-related mortality and morbidity is a major obstacle to be overcome. Treatment of MDS is likely to benefit from the major lines of investigation in the field of allogeneic transplantation, especially interventions postulated to decrease the morbidity of the procedure, such as less toxic preparative regimens. In this review we summarize current recommendations and controversies surrounding HSCT as well as integration of the novel therapeutic agents in the peritransplant period
Ex vivo generation of umbilical cord blood T regulatory cells expressing the homing markers CD62L and cutaneous lymphocyte antigen
No full textTargeting CLL-1 for acute myeloid leukemia therapy
No full textAbstract Despite major scientific discoveries and novel therapies over the past four decades, the treatment outcomes of acute myeloid leukemia (AML), especially in the adult patient population remain dismal. In the past few years, an increasing number of targets such as CD33, CD123, CLL-1, CD47, CD70, and TIM3, have been developed for immunotherapy of AML. Among them, CLL-1 has attracted the researchers’ attention due to its high expression in AML while being absent in normal hematopoietic stem cell. Accumulating evidence have demonstrated CLL-1 is an ideal target for AML. In this paper, we will review the expression of CLL-1 on normal cells and AML, the value of CLL-1 in diagnosis and follow-up, and targeting CLL-1 therapy-based antibody and chimeric antigen receptor T cell therapy as well as providing an overview of CLL-1 as a target for AML
Novel transplant strategies for generating graft-versus-leukemia effect in acute myeloid leukemia
No full text
Generation of Functional CLL-Specific Cord Blood CTL Using CD40-Ligated CLL APC
No full textPMCID: PMC3526610This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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