34 research outputs found
Six Characters In Search Of An Author
No full textProgram from the Little Theatre of Dallas' 1932 production of 'Six Characters In Search Of An Author,' written by Luigi Pirandello and directed by Charles Meredith. Setting arrangement by Alexandre Hogue. Cover art by Leon Dacus. Exhibitions by Olin Herman Travis and Kathryne Hail Travis
UA1C4/5/234 WKU Class of 1914
No full textLife certificates, 1914. Top row l to r: Murah Pace, W.L. Matthews, Bessie Beck, Harvey Roberts, Alta Barnhill, Anna Adams, James Randolph, Ethel Featherston, Orme Doolin and George Page. 2nd row l to r: Edyth Allen, Carrie Pennebaker, Bettie Shemwell, college dean A.J. Kinnaman, president Henry Cherry, class sponsor Robert Green, Lula Cole, Ora Blakeman, Clardy Moore and Ora Pruden. 3rd row l to r: Carl Ellis, Verlie Coffman, Bert Smith, Ruth Campbell, John Davis, Mary Edmonds, Clara Moorman, Estelle Bullock, Letitia Hocker and Lafe Sheffer. 4th row l to r: Ruth Meek, Walter Compton, Anna Davis, Carrie Davis, J.N. Witt, Jessie Northington, Andrew Parker, Edith Hampsch, C.S. Brown and Beulah Lovelayd. 5th row l to r: Hariet Bryant, J.W. Snyder, Maud Chambers, Edgar Sanders, Ruth Eubank, Finley Grise, Minnie Sweets, Maud Shultz, John Wade, Gertrude Cox and H.W. Puckett
The implementation of a metacognitive reading curriculum: An attempt to internalize expert reading characteristics in lower ability high school readers
No full textThis study reports the effects of two instructional reading approaches on students' reading achievement, metacognitive problem solving ability, reading attitude, and reading awareness (i.e., reading for meaning and reading to remember). The purpose of this study was to ascertain if it is possible to help lower ability high school students learn how to internalize expert reading characteristics by participating in a metacognitive reading curriculum. The subjects were 30 9th grade students enrolled in a Chapter I reading lab. The students in the treatment group received metacognitive and cognitive reading training by way of mental modeling, direct instruction/guided practice, peer interaction and individual autonomous use practice. The control group's program remained a constant individualized reading and interactive computer based program.The quantitative analysis indicated that the treatment group performed significantly better than the control group in the areas of reading achievement and reading awareness. There was no significant difference between the two groups' metacognitive problem solving ability, and reading attitudes toward becoming strategic readers.The qualitative analysis indicated that the treatment group gained a higher metacognitive and cognitive control over their reading when they had some degree of motivation and individual responsibility.The results indicate that the metacognitive reading intervention program is an effective tool for improving and helping students gain control over their reading achievement and their reading awareness. It is recommended that educators help lower ability high school students gain control over their learning and reading by providing them with metacognitive problem solving with perspective taking, content area classes utilizing the metacognitive reading curriculum's plan of study, and developing publishable video tapes of the metacognitive reading curriculum to be used by reading lab teachers, content area teachers, and students.Made available in DSpace on 2011-05-07T13:57:48Z (GMT). No. of bitstreams: 2
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Arden Club Plays by Date
No full textA list of all theatrical productions staged by the Arden Club and the Arden Workshop from the creation of the club in 1915 to 1969. The list includes the name of each play, its author, the month and year it was produced, and the names of the faculty directors associated with the production
Phylogenetic Clustering by Linear Integer Programming (PhyCLIP)
No full textSubspecies nomenclature systems of pathogens are increasingly based on sequence data. The use of phylogenetics to identify and differentiate between clusters of genetically similar pathogens is particularly prevalent in virology from the nomenclature of human papillomaviruses to highly pathogenic avian influenza (HPAI) H5Nx viruses. These nomenclature systems rely on absolute genetic distance thresholds to define the maximum genetic divergence tolerated between viruses designated as closely related. However, the phylogenetic clustering methods used in these nomenclature systems are limited by the arbitrariness of setting intra and intercluster diversity thresholds. The lack of a consensus ground truth to define well-delineated, meaningful phylogenetic subpopulations amplifies the difficulties in identifying an informative distance threshold. Consequently, phylogenetic clustering often becomes an exploratory, ad hoc exercise. Phylogenetic Clustering by Linear Integer Programming (PhyCLIP) was developed to provide a statistically principled phylogenetic clustering framework that negates the need for an arbitrarily defined distance threshold. Using the pairwise patristic distance distributions of an input phylogeny, PhyCLIP parameterizes the intra and intercluster divergence limits as statistical bounds in an integer linear programming model which is subsequently optimized to cluster as many sequences as possible. When applied to the hemagglutinin phylogeny of HPAI H5Nx viruses, PhyCLIP was not only able to recapitulate the current WHO/OIE/FAO H5 nomenclature system but also further delineated informative higher resolution clusters that capture geographically distinct subpopulations of viruses. PhyCLIP is pathogen-agnostic and can be generalized to a wide variety of research questions concerning the identification of biologically informative clusters in pathogen phylogenies. PhyCLIP is freely available at http://github.com/alvinxhan/PhyCLIP, last accessed March 15, 2019
Hepatitis C Virus Transmission Among Men Who Have Sex With Men in Amsterdam: External Introductions May Complicate Microelimination Efforts
No full textBACKGROUND: It is unclear whether unrestricted access and high uptake of direct-acting antivirals (DAAs) is sufficient to eliminate hepatitis C virus (HCV) in high-risk populations such as men who have sex with men (MSM). This study presents historic trends and current dynamics of HCV transmission among MSM in Amsterdam based on sequence data collected between 1994 and 2019. METHODS: Hypervariable region 1 sequences of 232 primary HCV infections and 56 reinfections were obtained from 244 MSM in care in Amsterdam. Maximum-likelihood phylogenies were constructed for HCV genotypes separately, and time-scaled phylogenies were constructed using a Bayesian coalescent approach. Transmission clusters were determined by Phydelity and trends in the proportion of unclustered sequences over time were evaluated using logistic regression. RESULTS: Seventy-six percent (218/288) of sequences were part of 21 transmission clusters and 13 transmission pairs. Transmission cluster sizes ranged from 3 to 44 sequences. Most clusters were introduced between the late 1990s and early 2010s and no new clusters were introduced after 2012. The proportion of unclustered sequences of subtype 1a, the most prevalent subtype in this population, fluctuated between 0% and 20% in 2009-2012, after which an increase occurred from 0% in 2012 to 50% in 2018. CONCLUSIONS: The proportion of external introductions of HCV infections among MSM in Amsterdam has recently increased, coinciding with high DAA uptake. Frequent international transmission events will likely complicate local microelimination efforts. Therefore, international collaboration combined with international scale-up of prevention, testing, and treatment of HCV infections (including reinfections) is warranted, in particular for local microelimination efforts
The efficacy of enzyme replacement therapy in patients with chronic neuronopathic Gaucher’s disease
No full textAsynchrony between virus diversity and antibody selection limits influenza virus evolution.
No full textSeasonal influenza viruses create a persistent global disease burden by evolving to escape immunity induced by prior infections and vaccinations. New antigenic variants have a substantial selective advantage at the population level, but these variants are rarely selected within-host, even in previously immune individuals. Using a mathematical model, we show that the temporal asynchrony between within-host virus exponential growth and antibody-mediated selection could limit within-host antigenic evolution. If selection for new antigenic variants acts principally at the point of initial virus inoculation, where small virus populations encounter well-matched mucosal antibodies in previously-infected individuals, there can exist protection against reinfection that does not regularly produce observable new antigenic variants within individual infected hosts. Our results provide a theoretical explanation for how virus antigenic evolution can be highly selective at the global level but nearly neutral within-host. They also suggest new avenues for improving influenza control
Whole genome sequencing unravels cryptic circulation of divergent dengue virus lineages in the rainforest region of Nigeria
No full textDengue is often misclassified and underreported in Africa due to inaccurate differential diagnoses of nonspecific febrile illnesses such as malaria, sparsity of diagnostic testing and poor clinical and genomic surveillance. There are limited reports on the seroprevalence and genetic diversity of dengue virus (DENV) in humans and vectors in Nigeria. In this study, we investigated the epidemiology and genetic diversity of dengue in the rainforest region of Nigeria. We screened 515 febrile patients who tested negative for malaria and typhoid fever in three hospitals in Oyo and Ekiti States in southern Nigeria with a combination of anti-dengue IgG/IgM/NS1 rapid test kits and metagenomic sequencing. We found that approximately 28% of screened patients had previous DENV exposure, with the highest prevalence in persons over sixty. Approximately 8% of the patients showed evidence of recent or current infection, and 2.7% had acute infection. Following sequencing of sixty samples, we assembled twenty DENV-1 genomes (3 complete and 17 partial). We found that all assembled genomes belonged to DENV-1 genotype III. Our phylogenetic analyses showed evidence of prolonged cryptic circulation of divergent DENV lineages in Oyo state. We were unable to resolve the source of DENV in Nigeria owing to limited sequencing data from the region. However, our sequences clustered closely with sequences in Tanzania and sequences reported in Chinese with travel history to Tanzania in 2019. This may reflect the wider unsampled bidirectional transmission of DENV-1 in Africa, which strongly emphasizes the importance of genomic surveillance in monitoring ongoing DENV transmission in Africa
Introduction and Establishment of SARS-CoV-2 Gamma Variant in New York City in Early 2021
No full text
