43 research outputs found
Long-Term Safety of Dapagliflozin in Older Patients with Type 2 Diabetes Mellitus: A Pooled Analysis of Phase IIb/III Studies
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Targeting the kidney and glucose excretion with dapagliflozin: preclinical and clinical evidence for SGLT2 inhibition as a new option for treatment of type 2 diabetes mellitus
No full textJean M Whaley,1 Mark Tirmenstein,2 Timothy P Reilly,2 Simon M Poucher,3 JoAnne Saye,4 Shamik Parikh,5 James F List61Bristol-Myers Squibb, Metabolic Disease Discovery Biology, Research and Development, Princeton, NJ, USA; 2Bristol-Myers Squibb, Drug Safety Evaluation, Research and Development, New Brunswick and Princeton, NJ, USA; 3AstraZeneca, Cardiovascular and Gastrointestinal Innovative Medicines Science Unit, Alderley Park, Macclesfield, Cheshire, UK; 4AstraZeneca, Global Safety Assessment, Research and Development, Wilmington, DE, USA; 5AstraZeneca, Cardiovascular, Clinical Development, Wilmington, DE, USA; 6Bristol-Myers Squibb, Global Clinical Development, Research and Development, Princeton, NJ, USAAbstract: Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a novel class of glucuretic, antihyperglycemic drugs that target the process of renal glucose reabsorption and induce glucuresis independently of insulin secretion or action. In patients with type 2 diabetes mellitus, SGLT2 inhibitors have been found to consistently reduce measures of hyperglycemia, including hemoglobin A1c, fasting plasma glucose, and postprandial glucose, throughout the continuum of disease. By inducing the renal excretion of glucose and its associated calories, SGLT2 inhibitors reduce weight and have the potential to be disease modifying by addressing the caloric excess that is believed to be one of the root causes of type 2 diabetes mellitus. Additional benefits, including the possibility for combination with insulin-dependent antihyperglycemic drugs, a low potential for hypoglycemia, and the ability to reduce blood pressure, were anticipated from the novel mechanism of action and have been demonstrated in clinical studies. Mechanism-related risks include an increased incidence of urinary tract and genital infections and the possibility of over-diuresis in volume-sensitive patients. Taken together, the results of Phase III clinical studies generally point to a positive benefit-risk ratio across the continuum of diabetes patients. To date, data on dapagliflozin, a selective SGLT2 inhibitor in development, demonstrate that the kidney is an efficacious and safe target for therapy, and that SGLT2 inhibition may have benefits for patients with type 2 diabetes mellitus beyond glycemic control.Keywords: type 2 diabetes mellitus, SGLT2, dapagliflozin, mechanism of actio
Understanding Brand Consistency from Web Content
No full textIf you want this dataset, kindly fill the "Request access" form towards the bottom of this page and also mail at : [email protected].
Kindly cite the paper : https://dl.acm.org/citation.cfm?id=3326048
BibTex :
@inproceedings{Roy:2019:UBC:3292522.3326048,
author = {Roy, Soumyadeep and Ganguly, Niloy and Sural, Shamik and Chhaya, Niyati and Natarajan, Anandhavelu},
title = {Understanding Brand Consistency from Web Content},
booktitle = {Proceedings of the 10th ACM Conference on Web Science},
series = {WebSci '19},
year = {2019},
isbn = {978-1-4503-6202-3},
location = {Boston, Massachusetts, USA},
pages = {245--253},
numpages = {9},
url = {http://doi.acm.org/10.1145/3292522.3326048},
doi = {10.1145/3292522.3326048},
acmid = {3326048},
publisher = {ACM},
address = {New York, NY, USA},
keywords = {affective computing, brand personality, reputation management, text classification},
}
Abstract :
Brands produce content to engage with the audience continually and tend to maintain a set of human characteristics in their marketing campaigns. In this era of digital marketing, they need to create a lot of content to keep up the engagement with their audiences. However, such kind of content authoring at scale introduces challenges in maintaining consistency in a brand's messaging tone, which is very important from a brand's perspective to ensure a persistent impression for its customers and audiences. In this work, we quantify brand personality and formulate its linguistic features. We score text articles extracted from brand communications on five personality dimensions: sincerity, excitement, competence, ruggedness and sophistication, and show that a linear SVM model achieves a decent F1 score of . The linear SVM allows us to annotate a large set of data points free of any annotation error. We utilize this huge annotated dataset to characterize the notion of brand consistency, which is maintaining a company's targeted brand personality across time and over different content categories; we make certain interesting observations. As per our knowledge, this is the first study which investigates brand personality from the company's official websites, and that formulates and analyzes the notion of brand consistency on such a large scale.
Dataset description:
Each file contain the scrapped textual content from the official webpages of Fortune 1000 companies. We use the 2017 Fortune 1000 list ranks. Please read the paper for details about data collection and cleaning
Directory structure : compressed size - 3.7 GB, uncompressed size - 28.9 GB
├── Cleaned MTlarge data
│ ├── final_dynamic_data.csv (1.0 GB) : Dynamic pages per company
│ └── final_static_data.csv (3.8 MB) : Static pages for each company
└── Raw Scrapped Data (27.8 GB)
├── first50fortune.csv : contains raw scrapped files for Fortune 1000 companies between the rank 1 and 50
├── fortune150_300.csv : Between Rank 150 and 300
├── fortune300_500.csv : Between Rank 300 to 500
├── fortune500_550.csv : Between Rank 500 and 550
├── fortune50_150.csv : Between Rank 50 and 150
├── fortune550_800.csv : Between Rank 550 and 800
└── fortune800_1000.csv : Between Rank 800 and 100
Case of ST-Elevation Myocardial Infarction in a 32-Year-Old Male Receiving Bleomycin, Etoposide, and Cisplatin Chemotherapy for Embryonal Carcinoma
No full textMyocardial infarction in young individuals has unique risk factors compared to the older population. Along with usual risk factors, one should explore causes such as recreational drug use, medication-induced myocardial infarction, and spontaneous coronary artery dissection. Here, we present the case of a 32-year-old male who presented with chest pain and was found to have complete thrombotic occlusion of the right coronary artery. He recently started receiving chemotherapy with bleomycin, etoposide, and cisplatin (PEB). In the absence of other risk factors and previous reports of similar cardiotoxicity with bleomycin, the patient was deemed to have an adverse effect from the chemotherapy regimen
Policy configuration and management in attribute based access control
No full textThe flexibility, scalability, dynamic nature, portability and identity-less features of Attribute Based Access Control (ABAC) make it an attractive choice to be employed as a means to enforce access control in many application domains.However, in order to realize the true benefit of ABAC, it is necessary to develop mechanisms to effectively configure, deploy, maintain, and manage it. Towards this end, this dissertation makes the following four contributions. First, we develop two ABAC policy mining algorithms that utilize existing permissions of users on the resources as well as the attribute information for both users and resources to automatically discover ABAC policies. Next, we develop an approach that can incrementally maintain ABAC policies by appropriately modifying the policy based on updates in permission and/or user/object attributes. Since commercially viable systems for implementation of ABAC are not widely available, we next address the deployment of ABAC on legacy systems. Specifically, we develop a low-cost approach for the translation of an ABAC policy into a form that can be adopted by an RBAC system. Our fourth and final contribution addresses policy reconciliation and migration in collaborative environments. Specifically, we propose the notion of policy equivalence in ABAC and develop methods to evaluate ABAC policy similarity. We also propose two different approaches for accomplishing policy reconciliation and an approach for policy migration. Together, this work helps organization to migrate to ABAC from the traditional discretionary access control (DAC), to efficiently maintain it in light of situational changes, and to deploy it in legacy systems and enable effective collaboration across organizations while respecting their individual security policies.Ph.D.Includes bibliographical reference
Genital and urinary tract infections in diabetes: Impact of pharmacologically-induced glucosuria
No full textAbstractPredisposition to genital infections and urinary tract infections (UTIs) in type 2 diabetes mellitus (T2DM) results from several factors such as glucosuria, adherence of bacteria to the uroepithelium and immune dysfunction. The tendency to develop these infections could be even higher in patients with T2DM treated with the emerging class of sodium–glucose cotransporter-2 (SGLT2) inhibitors. Studies have shown that pharmacologically-induced glucosuria with SGLT2 inhibitors raises the risk of developing genital infections and, to a relatively lesser extent, UTIs. However, a definitive dose relationship of the incidence of these infections with the SGLT2 doses is not evident in the existing data. Therefore, the precise role of glucosuria as a causative factor for these infections is yet to be fully elucidated
Dynamic composition and management of emergency response processes
No full textThe number of disasters, whether human-made or natural, has been on the rise over in the recent years; they have destroyed lives, homes, and caused widespread damage to infrastructure. The increase in disasters means there is also a higher demand for efficient response planning. Effective emergency response planning requires communication and coordination with the diverse operational systems belonging to various collaborating government agencies, non-government organizations (NGOs), and private sector entities. An essential requirement for developing an emergency response process is to establish information sharing and system-level interoperability among the operational systems of collaborating organizations. The challenge is that emergency response processes are not well-structured and do not have a well-defined outcome; they are knowledge-centric. Their workflow structure and execution may evolve dynamically based on the environmental context and the type of service or activity invoked during process execution. It is impractical to define static plans and response process workflows for every possible situation since unforeseeable situations may arise. Thus, a dynamic response requires adaptability to a changing situation as an incident evolves.
In this thesis, we develop an iterative end-to-end solution for the dynamic composition and management of an Emergency Response Management System, called Dynamic Emergency Response Processes System (DERPS). DERPS allows the Incident Commander to develop a contextualized response using ontology-based reasoning and allows its dynamic adaptation to situational changes. We also adapt and apply DERPS in the COVID-19 context. Specifically, given the pandemic’s scale and scope, home-based isolation has been considered a potential first step to reduce the spread of the virus and limit the stress on the healthcare system. However, home-based isolation needs and requirements are unique for each patient. We show how DERPS can be utilized to develop personalized patient care plans to ensure that each patient’s needs are appropriately met while they are confined to their home. We develop a prototype implementation to show the feasibility of the proposed framework and discuss challenges and issues in deploying such a system in practice.Ph.D.Includes bibliographical reference
Evaluation of the effect of dapagliflozin on cardiac repolarization: a thorough QT/QTc study
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