87 research outputs found
Chronic lymphocytic leukemia developing in a case of chronic myelogenous leukemia: Some observations
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Pharmacovigilance Evaluation of the Association Between DPP-4 Inhibitors and Heart Failure: Stimulated Reporting and Moderation by Drug Interactions
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Deterministic annealing algorithm: tutorial, application to pickup and delivery problem and computational aspects
No full textThe deterministic annealing (DA) method, used for the solution of several nonconvex problems, offers the ability to avoid shallow local minima of a given cost surface and the ability to minimize the cost function even when there are many local minima. The method is established in a probabilistic framework through basic information-theoretic techniques such as maximum entropy and random coding. It arises naturally in the context of statistical mechanics by the emulation of a physical process whereby a solid is slowly cooled and at zero temperature assumes its minimum energy configuration. We start with the introduction to DA method and then present a tutorial to describe the algorithm steps. Also, we discuss the connections of DA method with Statistical Mechanics and Rate-Distortion Theory. Next, we present the application of DA method to pickup and deliver scheduling problem with time windows. Finally, a computational complexity analysis for DA is presented for a given temperature schedule. The case study focuses on the geometric cooling law , where is the temperature at time .Submission published under a 24 month embargo labeled 'U of I only', the embargo will last until 2017-05-01The student, Pratik Mayur Parekh, accepted the attached license on 2015-04-29 at 11:47.The student, Pratik Mayur Parekh, submitted this Thesis for approval on 2015-04-29 at 11:54.This Thesis was approved for publication on 2015-04-30 at 15:06.DSpace SAF Submission Ingestion Package generated from Vireo submission #8183 on 2015-07-22 at 14:19:02Made available in DSpace on 2015-07-22T22:34:01Z (GMT). No. of bitstreams: 2
PAREKH-THESIS-2015.pdf: 1206816 bytes, checksum: 55dda3d59a2fd68c519e62a706ce7365 (MD5)
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Previous issue date: 2015-04-30Embargo set by: Seth Robbins for item 79929
Lift date: 2017-07-22T22:34:16Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 79929 on 2017-07-23T09:15:19Z
Correlation of clinicopathological outcomes with changes in IHC4 status after NACT in locally advanced breast cancers: do pre-NACT ER/PR status act as better prognosticators?
No full textSanjoy Chatterjee,1 Animesh Saha,1 Indu Arun,2 Sonali Susmita Nayak,2 Subir Sinha,3 Sanjit Agrawal,4 Mayur Parihar,5 Rosina Ahmed4 1Department of Radiation Oncology, 2Department of Pathology, 3Department of Medical Statistics, 4Department of Breast Surgery, 5Department of Molecular Pathology, Tata Medical Center, Kolkata, West Bengal, India Background: Following neoadjuvant chemotherapy (NACT) for breast cancer, changes in estrogen receptor (ER), progesterone receptor (PR), HER2 status, and Ki-67 index (IHC4 status) and its correlation with pathological complete response (pCR) or relapse-free survival (RFS) rates could lead to better understanding of tumor management. Patients and methods: Pre- and post-NACT IHC4 status and its changes were analyzed in 156 patients with breast cancer. Associations between pCR, RFS rates to IHC4 status pre- and post-NACT were investigated. Results: pCR was found in 25.3% patients. Both ER and PR positive tumors had the lowest (14.3%) pCR compared to ER and PR negative (29%) or either ER-/PR-positive (38.6%) tumors. PR positivity was significantly associated with less likelihood of pCR (15% versus 34%). The pCR rate was low for luminal A subtype (13.68%) compared to 24.36%, 26.31%, and 33.33% for luminal B, HER2-enriched, and triple-negative subtypes, respectively. There was significant reduction in ER expression and Ki-67 index post-NACT. RFS of patients in whom the hormonal status changed from positive to negative was better compared to those of patients in whom the hormonal status changed from negative to positive. Conclusion: Although changes in IHC4 occurred post-NACT, pre-NACT hazard ratio status prognosticated RFS better. pCR and RFS rates were lower in PR-positive tumors. Keywords: neoadjuvant chemotherapy, IHC4 status changes, survival 
Telomerase-associated apoptotic events by mushroom Ganoderma lucidum on premalignant human urothelial cells
No full textAuthor name used in this publication: Mayur Danny I. Gohel2007-2008 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishedGreen (AAM
associated sarcomas and pleuropulmonary blastoma: Histopathologic features guide diagnosis in the LMIC setting
No full textExtrapulmonary DICER1-associated sarcomas (DS) can harbor morphological features overlapping with pleuropulmonary blastoma. We report 3 children with intracranial and genital tract sarcomas, suspected to have DS based on a heterogeneous yet defining combination of spindle-cell sarcomatous and blastemal morphology, with rhabdomyomatous differentiation. Foci of immature cartilage at diagnosis (n=2/3) and increased neuroepithelial differentiation at recurrence (n=1) were noted. Morphological suspicion prompted somatic testing at reference centers, confirming likely biallelic, loss-of-function and ‘hotspot’ missense DICER1 variants in all 3 tumors. This can serve as a model for this diagnosis in resource-limited settings and has implications for germline testing, surveillance, and tumor management
Synergistic cytotoxic effects of ganoderma lucidum and bacillus calmette guérin on premalignant urothelial HUC-PC cells and its regulation on proinflammatory cytokine secretion
No full textAuthor name used in this publication: John Wai-man YuenAuthor name used in this publication: Mayur-Danny I. Gohel2012-2013 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishedC
Numerical analysis of unsteady compressible flow in the hose of Bubble Curtain Technology
No full textThe offshore wind industry is rapidly advancing, expected to play a crucial role in renewable energy production, with a growing emphasis on addressing associated environmental concerns, particularly the impact of underwater noise generated during the installation of wind turbines. In response, bubble curtain technology (BCT) has emerged as a potential solution. While the BCT operational concept has been demonstrated in practice, a detailed investigation related to fluid dynamics, geometric characteristics, and operational parameters has yet to be conducted. It's important to note that this need for investigation is specifically applicable to large BCT systems. This research aims to enhance the understanding of unsteady compressible flow inside BCT hoses and examine the impact of operational parameters on the pneumatic aspects of the bubble curtain system along the hose length.This thesis systematically defined its fundamental objectives, beginning with the development of a 1D unsteady model for compressible flow in pipeline systems. This model, which served as the basis for subsequent studies, was verified against the existing literature, revealing a 2-4% difference in flow rates and pressure responses. Subsequently, the scope was broadened to include nozzle configurations, which were gradually included in the pipeline model. The model evolved through configurations with one, three, and five nozzles, where larger diameters increased dampening on transient pressure fluctuations. As the research progressed, the final model, incorporating five nozzles, was used as the basis for the scaled Bubble Curtain Technology (BCT) model.A sensitivity analysis for this study was carried out utilizing parameters from existing research. The sensitivity study specifically emphasized the influence of geometric (hose and nozzle diameters, hose length, nozzle spacing) and operational factors (discharge coefficient, water depth, air flow rate) on the flow dynamic of Bubble Curtain Technology (BCT). The main findings from this research included reducing backflow with smaller diameters and lowering reverse flow with greater discharge coefficients and airflow rates. Changing the hose length and nozzle spacing proved effective for adjusting the required flow rates. The investigation also found that nozzle diameter and discharge coefficient had a considerable impact on nozzle flow rates, with a 2-3% increase over reference values at the maximum value range. Other geometric and operational parameters in the tested ranges had a relatively lower influence on the nozzle flow rates or generated pressure variations.The scaled BCT unsteady compressible flow dynamics model presented in this thesis is still in its early stages of development, but it can serve as a basis for the development of full-scale pneumatic models that can enhance BCT and lessen the environmental impact of offshore wind farm operations.Offshore and Dredging Engineerin
Subjective Versus Objective: An Exploratory Analysis of Latino Primary Care Patients With Self-Perceived Depression Who Do Not Fulfill Primary Care Evaluation of Mental Disorders Patient Health Questionnaire Criteria for Depression
No full textObjective: Identification and treatment of depression may be difficult for primary care providers when there is a mismatch between the patient’s subjective experiences of illness and objective criteria. Cultural differences in presentation of symptoms among Latino immigrants may hinder access to care for treatment of depression. This article seeks to describe the self-perceptions and symptoms of Latino primary care patients who identify themselves as depressed but do not meet screening criteria for depression.
Method: A convenience sample of Latino immigrants (N = 177) in Corona, Queens, New York, was obtained from a primary care practice from August 2008 to December 2008. The sample was divided into 3 groups according to whether participants met Patient Health Questionnaire diagnostic criteria for depression and whether or not participants had a self-perceived mental health problem and self-identified their problem as “depression” from a checklist of cultural idioms of distress. Psychosocial, demographic, and treatment variables were compared between the 3 groups.
Results: Participants’ descriptions of symptoms had a predominantly somatic component. The most common complaints were ánimo bajo (low energy) and decaimiento (weakness). Participants with “subjective” depression had mean scores of somatic symptoms and depression severity that were significantly lower than the participants with “objective” depression and significantly higher than the group with no depression (P < .0001).
Conclusions: Latino immigrants who perceive that they need help with depression, but do not meet screening criteria for depression, still have significant distress and impairment. To avoid having these patients “fall through the cracks,” it is important to take into account culturally accepted expressions of distress and the meaning of illness for the individual.Peer reviewe
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