5,004 research outputs found
Therapeutics and Vaccines Against Pathogenic Escherichia coli
No full textDiarrheagenic E. coli continues to be an important pathogen causing significant illness in animals and humans. Despite the fact that considerable investigations have been done following the initial discovery of enterotoxigenic Escherichia coli (ETEC) and enterohemorrhagic E. coli (EHEC), there are currently no available licensed and broadly protective, ETEC nor EHEC vaccines. The significant, yet unsuccessful efforts in obtaining a vaccine candidate have provided important information on strategies to consider in future formulations. There are now new promising vaccine candidates based on this pioneering work, even though they have not generated successful vaccines. This chapter is focused on outstanding findings and their impact in human public health.Fil: Palermo, Marina Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Flores Figueroa, José. Jm Research; MéxicoFil: Paredes Paredes, Mercedes. Jm Research; Méxic
Plan de Marketing para la Empresa IMPORAUTO JM, en la ciudad de Santo Domingo, para el año 2022
No full textLa Empresa IMPORAUTO JM, administrada por su propietaria la señora Mirian Triguero y su Gerente Comercial el señor Jorge Gómez, se dedica a la Distribución y Comercialización de productos para el sector automotriz y motocicletas, tales como: lubricantes, grasas, bujías, siliconas, líquidos de frenos, refrigerantes, entre otros; en la ciudad de Santo Domingo y sus alrededores, efectuado atención directa a establecimientos que usan y comercializan productos relacionados con el sector automotriz. La presente investigación brinda un análisis relacionado al mejoramiento de las ventas, que debe efectuar la Empresa IMPORAUTO JM, para mejorar sus niveles de ingresos y rentabilidad, y entendiendo las variables que influyen en la percepción del mercado objetivo, al cual se dirige su atención y servicio. Actualmente la Empresa IMPORAUTO JM, ha mantenido sus mismos niveles de ventas, por la falta de estrategias de marketing que ayuden a su crecimiento, por lo cual se investigó los fundamente teóricos relacionados con el marketing comercial, los mismos que fueron de gran apoyo para determinar la correcta metodología que se adaptó a las necesidades de marketing de la Empresa, dando como resultado el diseño de plan de marketing viable, que permitirá el mejoramiento de las ventas de la Empresa IMPORAUTO JM.Resumen. Abstract. Introducción. Problemática. Formulación del problema. Objeto teórico. Objeto práctico. Sistematización del problema. Tipo, nivel y modalidad de la investigación. Objetivos. Justificación. Métodos de investigación. Marco referencial. Marketing. Estrategias de marketing. Plan de marketing. Marco conceptual. Metodología. Propuesta de diseño metodológico de plan de marketing. Propuesta de procedimiento de plan de marketing para la empresa imporauto jm. Fase 1: preparación y diagnóstico. Fase 2: diseño estratégico. Conclusiones y recomendaciones. Bibliografía. Anexos
Progreso en la práctica del ajuste gaussiano de una red local: método de Triangulateración
No full textJiménez Martínez, MJ.; Marqués Mateu, Á.; Paredes Asencio, JM.; Villar Cano, M. (2011). Progreso en la práctica del ajuste gaussiano de una red local: método de Triangulateración. RACV Digital. 1-131. https://riunet.upv.es/handle/10251/47995S113
The SSC of the Generalised Jahangir’s Graph Jm,k and its Algebraic Characterizations
No full textIn this article, we present important combinatorial and algebraicproperties of spanning simplicial complex (SSC) of the generalised Jahangir’sgraph Jm,k. We describe the relation to find f−vectors associatedto Δs(Jm,k) and determine the Hilbert series for the SR-ring KΔs(Jm,k).In the end, we present the associated primes of the facet ideal IF(Δs(Jm,k))and the Cohen-Macaulay characterization of the SR-ring of Δs(Jm,k).AMS (MOS) Subject Classification Codes: Primary 13-P10, Secondary 13-F20, 13-C14, 13-H10.Corresponding Author: Agha KashifKey Words: Simplicial Complexes, f-vectors, Spanning Trees, Face Ring, Hilbert Series, CohenMacaulay
To <i>JM</i> on Its 75th Anniversary
No full text This article discusses how Journal of Marketing ( JM) has influenced marketing science and practice by publishing articles on substantive topics relevant to customers, managers, organizations, markets, and society. The journal's 75th anniversary coincides with the 50th anniversary of the Marketing Science Institute (MSI). Frequently, JM and MSI have collaborated to address important substantive marketing issues identified in MSI's Research Priorities. The author highlights seminal articles on brand equity; business-to-business marketing (including sales force management); connecting marketing information, metrics, and strategy; consumer behavior; innovation, new product development. and product management; marketing orientation and capabilities; and market research, methodology and services. She also draws attention to articles that have won the Sheth Foundation/ JM Award and the H. Paul Root Award. The article describes how JM‘s knowledge dissemination is amplified by powerful social network effects. Ideas in JM articles diffuse through the business community, influencing the mind-set of managers worldwide. </jats:p
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species
No full text\ua9 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.Studies showed that JM-20, a benzodiazepine-dihydropyridine hybrid molecule, protects against rotenone and 6-hydroxydopamine neurotoxicity. However, its protective effects against cytotoxicity induced by endogenous neurotoxins involved in Parkinson’s disease (PD) pathogenesis have never been investigated. In this study, we evaluated the ability of JM-20 to inhibit alpha-synuclein (aSyn) aggregation. We also evaluated the interactions of JM-20 with aSyn by molecular docking and molecular dynamics and assessed the protective effect of JM-20 against aminochrome cytotoxicity. We demonstrated that JM-20 induced the formation of heterogeneous amyloid fibrils, which were innocuous to primary cultures of mesencephalic cells. Moreover, JM-20 reduced the average size of aSyn positive inclusions in H4 cells transfected with SynT wild-type and synphilin-1-V5, but not in HEK cells transfected with synphilin-1-GFP. In silico studies showed the interaction between JM-20 and the aSyn-binding site. Additionally, we showed that JM-20 protects SH-SY5Y cells against aminochrome cytotoxicity. These results reinforce the potential of JM-20 as a neuroprotective compound for PD and suggest aSyn as a molecular target for JM-20
Uterine transplantation: a promising surrogate to surrogacy?
No full textUterine transplantation: a promising surrogate to surrogacy?
Grynberg M1, Ayoubi JM, Bulletti C, Frydman R, Fanchin R.
Author information
Abstract
Infertility due to the inability of the uterus to carry a pregnancy ranks among the most unresolved issues in reproductive medicine. It affects millions of women worldwide who have congenital or acquired uterine affections, often requiring hysterectomy, and potentially represents a considerable fraction of the general infertile population. Patients suffering from severe uterine infertility are currently compelled to go through gestational surrogacy or adoption; both approaches, unfortunately, deprive them of the maternal experience of pregnancy and birth. Uterine transplantation represents an outstanding, yet complex, perspective to alleviating definitive uterine infertility. In the past decades, a number of scientific experiments conducted both in animals and women, focusing on uterine transplantation, have led to promising results. Collectively, these findings undoubtedly constitute a sound basis to clinically apply uterine transplantation in the near future. This paper is, however, an overview not only of the extent and limitations of accumulated scientific knowledge on uterine transplantation, but also its ethical implications, in an effort to define the actual place of such an approach among the therapeutic arsenal for alleviating infertility.
© 2011 New York Academy of Sciences
Translation and interpretation: Translation redundancy reconsidered
No full textInterpretation is an integral part of the process of translating. This article raises the question of whether interpretation fo a literary work by a translator should be guided by extratextual factors or not. The discussion is illustrated with examples taken from David Hawkes' translation of a Chinese classic, A Dream of Red Mansions. As the work of a scholar-translator, Hawkes' version is richly supplemented with disclosures concerning the characters and explanations of the cultural environment embodied in the novel. In many cases, however, this translation procedure is redundant and explanatory, enlightening the readers but at the same time robbing them of the pleasure of literary interpretation and cultural exploration. By means of this illustration of translation redundancy, the author points out that there is difference between a scholar who helps the interpretation fo a work and a translator who presents a work close to its original version. It is particularly important to pay attention tot his difference in literary translations in a cross-cultural situation involving two enormously different cultures.Language & LinguisticsA&HCI0ARTICLE1,SI115-12
Desarrollo de un sistema de aseguramiento de la calidad en una empresa dedicada a la contrucción de viviendas según la norma UNE-EN-ISO 9001:2000
No full textConsulta en la Biblioteca ETSI Industriales (5678)[ES] En la actualidad, y cada vez de forma más acentuada, la calidad es un objetivo
de primera línea en cualquier actividad económica. Se está convirtiendo en una
estrategia de competitividad superando la aceptación inicial de estrategia de marketing o
de ventas.
Para conseguir la calidad es necesario conocer lo que la palabra calidad significa
en su sentido más amplio, y no solamente referida al producto o servicio al que se le
aplica. También es imprescindible una adecuada planificación de todas las acciones y
actividades de la organización, así como una correcta gestión de todos los recursos
materiales y humanos, encaminadas ambas a la consecución de la calidad.Sánchez Paredes, JM. (2006). Desarrollo de un sistema de aseguramiento de la calidad en una empresa dedicada a la contrucción de viviendas según la norma UNE-EN-ISO 9001:2000. https://riunet.upv.es/handle/10251/37221.Archivo delegad
INTERNATIONAL FINANCIAL REPORTING STANDARDS (IFRS), BAIK BAGI USAHA MIKRO KECIL MENENGAH? (Studi Kasus: UMKM JM KERIPIK)
No full textABSTRAKUndang-undang nomor 20 tahun 2008 tentang Usaha Makro Kecil Menengah (UMKM), usaha kecil adalah usaha ekonomi produktif yang berdiri sendiri, yang dilakukan oleh orang perseorangan atau badan usaha yang bukan merupakan anak perusahaan atau bukan cabang perusahaan yang memiliki, dikuasai atau menjadi bagian baik langsung maupun tidak langsung dari usaha menengah atau usaha besar yang memenuhi kriteria. JM Keripik merupakan salah salah UMKM yang bergelut dibidang produksi dan penjualan. IFRS merupakan seperangkat standard yang dikeluarkan oleh Dewan Standard Akuntansi Internasional (IASB). IFRS berguna untuk menyusun laporan keuangan yang dapat diterima di dunia Global.Penulistertarik untukmengetahuipencatatankeuanganJM Keripik dan apakah perlu merekomendasikan IFRS pada UMKM JM Keripik. Metode penelitian yang digunakaan penulis adalah kualitatif yaitu observasi dan wawancara. Dari hasil penelitian banyak terdapat pencatatan-pencatatan yang kurang terperinci, UMKM JM Keripik hanya memilki empat macam pencatatan yaitu pencatatan mengenai: 1.Stock barang, 2.Supliyer, 3.Costumer dan 4.Stock toko, pencatatan ini hanya dapat dimengerti oleh pemilik JM Keripik. Sebaiknya pemilik UMKM JM Keripik mengganti laporan keuangan yang sederhana ke laporan keuangan yang semestinya dan yang berbasis IFRS karena IFRS membawa dampak positif bagi UMKM dan merupakan standar akuntansi keuangan yang digunakan dunia global. Kata Kunci : UMKM, IFRS, JM Keripik ABSTRACT Act number 20 of 2008 concerning the Macro Small and Medium Enterprises, small businesses are productive economic activities that stand alone, carried out by an individual or business entity that is not a subsidiary or not a branch of the company that owns, controlled or become part either directly or indirectly from medium or large businesses that meet the criteria. JM Keripik which deals in the field of production and sales. IFRS is a set of standards issued by the International Accounting Standards Board (IASB). IFRS is useful for preparing financial statements that is acceptable in the global world. Authors interested in knowing the financial records of JM Keripik and whether to recommend IFRS on JM Keripik. The research method is qualitative author of observation and interviews. From the research there are many registries are less detailed, JM Keripik has only four kinds of recording is recording about: 1.Stock goods, 2.Supliyer, 3.Costumer and 4.Stock shop, registration can only be understood by the owner of JM Keripik. JM Keripik owners should replace the simple financial reports to the appropriate financial statements and IFRS-based IFRS for Macro Small and Medium Enterprises had a positive impact and a financial accounting standards global world. Keywords : UMKM, IFRS, JM Keripi
- …
