1,723,021 research outputs found
Pardis Mahdavi Interview - Open Access to Undergraduate Scholarship
No full textPardis Mahdavi is the Chair and Associate Professor of Anthropology; Dean of Women; Director, the Pacific Basin Institute; Coordinator of Gender and Women\u27s Studies at Pomona College. Professor Mahdavi was interviewed about the importance and benefits in sharing undergraduate research online.
This video is one in a series asking participants to talk about their experience with supporting online undergraduate research so that faculty and students at the colleges understand the opportunities and benefits of open access to these works
Recall this Book 59: Pardis Dabashi on "My Uncle Napoleon"
No full textIraj Pezeshkzad's My Uncle Napoleon is a slapstick and at times goofy love story, but it is also in the best tradition of sly anti-imperial satire. Scholar Pardis Dabashi came to it late, but she has all the convert's zeal as she links it to a literary tradition that's highly theoretical, but also delightfully far-flung
Retrospective from departing UM Provost Pardis Mahdavi
Full text linkThis week\u27s guest is Dr. Pardis Mahdavi, an Iranian-American professor, administrator, outgoing provost at the University of Montana, and the newly named president of the University of La Verne. Pardis is the author of multiple books and served in leadership roles in several prominent universities.
In this episode Justin asks Pardis about her path into academia, what changes to the University of Montana and higher ed more broadly she would like to see and her goals for the new role as president of the University of La Verne.https://scholarworks.umt.edu/anewangle_podcasts/1307/thumbnail.jp
Regulatory aspects of artificial intelligence on blockchain Advances in computational intelligence and robotics (ACIR) book series./ Pardis Moslemzadeh Tehrani, editor.
No full textIncludes bibliographical references and index."This book provides relevant legal and security frameworks and the latest empirical research findings in the area of blockchain and AI striving to identify and overcome the legal consequences of the application of Artificial Intelligence into the blockchain system"--Vulnerability of blockchain network from consensus perspective / Mohamed Ikbal Nacer, Simant Prakoonwit -- A Pragmatic Regulatory Framework for Artificial Intelligence : Regulating Artificial Intelligence / Karisma Karisma -- A Contextual Study of Regulatory Framework for Blockchain / Mohmmad Abdullah Fazi, Multimedia -- Legal and Regulatory Landscape of Blockchain Technology in Countries : Legislations Addressing Blockchain Technology / Karisma Karisma, Pardis Moslemzadeh Tehrani -- Comparative Review of the Regulatory Framework of Cryptocurrency in Selected Jurisdictions : Insights on Cryptocurrency Regulations / Karisma Karisma -- The Legality of Smart Contract in Decentralized Autonomous Organization / Andasmara Rizky Pranata, Pardis Moslemzadeh Tehrani -- Blockchain Technology in China's Digital Economy : Balancing Regulation and Innovation / Poshan Yu, Ruixin Gong, Michael Sampat -- Blockchain Applications in the Energy Industry / Soheil Saraji, Christelle Khalaf -- Cryptocurrency and Blockchain: The Future of a Global Banking System / Namrata Dhanda -- Clickwrap Agreement : An Analysis of the Terms of the Cloud Agreement and Studying the Benefits of Adopting Such Methods / Dhiviya A/P Ramanathan -- Bitcoin prediction using multi-layer perceptron regressor, PCA and support vector regression (SVR) / Atif Jamshid, Asmita Dixit.1 online resource (xxix, 273 pages)
Urban expansion Tehran-Pardis
Full text linkEin neues Wohnkonzept für Pardis Teheran ist mit einer Fläche von 1.500 Quadratkilometern eine der größten und bevölkerungsreichsten Städte Westasiens. Teheran ist dermaßen überlastet, dass sich durchschnittlich 1,6 Personen ein Zimmer teilen müssen. Teheran ist somit überfüllt und benötigt eine Stadterweiterung. Im Rahmen der vorliegenden Diplomarbeit wird versucht, eine Alternative zur derzeitigen Stadterweiterung in Teheran-Pardis zu entwickeln und es werden neue Möglichkeiten aufgezeigt. Eines der erfolgreichsten Beispiele für klimagerechte Architektur sind traditionelle Innenhöfe im heißen Iran, die unter Berücksichtigung der klimatischen Anforderungen und der soziokulturellen Kontexte entworfen wurden . Das Projekt ist insbesondere von traditionellen persischen Hofhäusern inspiriert, und deren organische form erzeugt eine eigene Art der Siedlung. Die Privatsphäre, die in der islamischen Kultur des Irans sehr wichtig ist, wurde in dem Projekt stark berücksichtigt.A New Living Concept for Pardis With an area of 1,500 square kilometers, Tehran is one of the largest and most populous cities in Western Asia. Tehran is so overloaded that on average 1.6 people have to share a room. Tehran is thus overcrowded and needs a city extension. This diploma thesis tries to develop an alternative to the current urban expansion in Tehran-Pardis and shows new possibilities. One of the most successful examples of climate-friendly architecture are traditional courtyards in hot Iran, designed with the climatic requirements and socio-cultural contexts in mind. The project is particularly inspired by traditional Persian court houses, and their organic form creates their own kind of settlement. The privacy, which is very important in the Islamic culture of Iran, has been strongly considered in the project
My body is a soft clay temple - selected poems
No full textPardis Aliakbarkhani\u27s selected poems, My body is a soft clay temple is an exploration in fat personal history, fat love, and connection to the body
Characterization of human monoclonal antibodies against Neisseria gonorrhoeae and cognate antigen discovery
No full textGonorrhea, caused by the Gram negative bacterium Neisseria gonorrhoeae, affects millions of people globally. The lack of a vaccine and the increasing rates of antibiotic resistance make infection control difficult and underline the need for novel therapeutics. In this framework, monoclonal antibodies (mAbs) endowed with bactericidal activity have potential for treating bacterial infections resistant to currently available medications. This research project sought to isolate human mAbs and their cognate antigens as possible new tools for prevention and treatment of gonorrhea.
The technology exploited here is named Reverse Vaccinology 2.0 and consisted in isolating plasma cells (PCs) and memory B cells (MBCs) from volunteers vaccinated with the anti-meningococcal vaccine Bexsero. The rationale for this approach relies on a retrospective study that demonstrated 31% cross-protection against gonorrhoea in people who had received Bexsero. Antibodies produced by PCs and MBCs were analysed to determine their binding profile to N. gonorrhoeae and functionality in vitro. The targets of the mAbs were then searched by combining genetic and biochemical studies.
Although mAbs produced by PCs bound to a wide variety of N. gonorrhoeae strains, they were unable to kill the pathogen in complement-dependent assays. On the other hand, mAbs derived from MBCs displayed more interesting features. For instance, mAb_1 was bactericidal against the FA1090 strain. The anti-lipooligosaccharide (LOS) mAb_3 recognized distinct strains of N. gonorrhoeae (FA1090, BG27, F62, MS11) with different LOS structures thereby suggesting the existence of a common epitope. Monoclonal antibody 4 (mAb_4) bound specifically to an antigen named BamG (NGO_1985) involved in outer membrane biogenesis and stability. We chose to concentrate on characterizing this monoclonal and its target because this antigen is included in the approved meningococcal vaccination and provides protection in the animal model. Investigations of the interaction between mAb_4 and BamG were carried out in silico and predicted the epitope contacted by mAb_4. Crystallography trials were initiated with the purpose of determining the crystal structure of the complex. Of note, an effective immunoprecipitation/mass spectrometry (IP/MS) protocol for pinpointing mAb targets was established by including BamG/mAb_4 interactors as positive controls.
Overall, this study generated a significant contribution to understanding the molecular bases of the cross-protection afforded by Bexsero and may provide guidance for future developments of antibody cocktail therapeutics, protein-based vaccines, and in vivo research
Neighborhood Redefined: Creating Culture in the Interstitial Spaces in New Town of Pardis, Iran
Full text linkLow-cost housing developments forming “the new towns” adjacent to the metropolitan cities in Iran were aimed to accommodate low-income households. However, after a decade of occupancy, the inhabitants of these towns are struggling with inadequate public facilities to provide human interaction within their neighborhoods. This thesis aims to repurpose the interstitial spaces between the residential towers in the new town of Pardis. The current urban development has created isolated residential point towers which lead to emerging a desolate landscape in the spaces between them, however, the thesis proposes multipurpose social activities and means of connection that encourages social interaction. This research tackles the current issue by examining cultural elements of Iranian neighborhoods and adapting them in the context of the Pardis new town. Precedents of successful existing neighborhoods with similar climate are studied. Subsequently, after analysing the Pardis site in general, a portion of it is chosen as a prototype to investigate the issue in human scale by producing 3D models of the suggested design intervention. This prototypical study could eventually be applied to other neighborhoods in Pardis as well as new towns with similar climate and topographic features to enhance the quality of residents’ social life
Outbreak culture: the Ebola crisis and the next epidemic, with a new preface and epilogue/ Pardis Sabeti and Lara Salahi
No full textIn English.Includes bibliographical references and indexA Choice Outstanding Academic Title of the Year "A critical, poignant postmortem of the epidemic." --Washington Post "Forceful and instructive...Sabeti and Salahi uncover competition, sabotage, fear, blame, and disorganization bordering on chaos, features that are seen in just about any lethal epidemic." --Paul Farmer, cofounder of Partners in Health "The central theme of the book...is that common threads of dysfunction run through responses to epidemics...The power of Outbreak Culture is its universality." --Nature "Sabeti and Salahi present a wealth of evidence supporting the imperative that outbreak response must operate in a coordinated, real-time manner." --Science As we saw with the Ebola outbreak--and the disastrous early handling of the COVID-19 coronavirus pandemic--a lack of preparedness, delays, and system-wide problems with the distribution of critical medical supplies can have deadly consequences. Yet after every outbreak, the systems put in place to coordinate emergency responses are generally dismantled. One of America's top biomedical researchers, Dr. Pardis Sabeti, and her Pulitzer Prize-winning collaborator, Lara Salahi, argue that these problems are built into the ecosystem of our emergency responses. With an understanding of the path of disease and insight into political psychology, they show how secrecy, competition, and poor coordination plague nearly every major public health crisis and reveal how much more could be done to safeguard the well-being of caregivers, patients, and vulnerable communities. A work of fearless integrity and unassailable authority, Outbreak Culture seeks to ensure that we make some urgently needed changes before the next pandemic.Cover -- Title Page -- Copyright -- Dedication -- Contents -- Acronyms and Abbreviations -- Preface to the Paperback Edition -- Map of West Africa -- Prologue: The People's Fighter -- 1. Setting for Disaster -- 2. The Crucible of Outbreak Response -- 3. The Case for Collaboration -- 4. The Wavering Response -- 5. Distrust in a Culture of Compassion -- 6. Epidemic of Fear -- 7. Investment and Accountability -- 8. Ebola's Fallout -- 9. Navigating the Next Epidemic -- Epilogue to the Paperback Edition -- Notes -- Acknowledgments -- Index1 online resourc
Role of stem-like cells in breast cancer
No full textBreast cancer is a leading cause of mortality in women worldwide, with a high incidence of tumour recurrence and metastasis, predominantly due to chemoresistance, key obstacles in the treatment of any cancer. Studies are emerging in support of the “cancer stem cells theory”, which postulates that a small subset of cancer cells is exclusively responsible for the initiation and malignant behaviour of a cancer that are highly tumorigenic, resistant to therapeutic regimes, and responsible for treatment failure and disease relapse. The emergence of cancer is also accompanied by specific metabolic alterations; in particular, enhanced aerobic glycolytic activity which leads to rapid tumour progression. Our current conventional therapies are based on eliminating differentiated tumours, whereas identification of the factors that lead to cancer stem-like cells (CSLCs) maintenance in the tumour population, could lead to the development of more effective therapeutics. Therefore, this thesis aimed to investigate the effect of modulating tumour cell metabolism, using a variety of metabolic inhibitors, on the maintenance of the stem cell population of breast cancer cells, to stop or slow down CSLCs growth. Additionally, this thesis aimed to study the expression levels of the main stem cell markers SOX2, OCT4, and its most homologous pseudogene (OCT4 PG1), in breast cancer following metabolic treatments and to investigate the effect of reducing the expression of these markers on the mammosphere forming ability of MCF-7 cells. We developed a cell line model of glycolytic vs. glycolysis restricted cells by adapting cells to fructose in the absence of glucose so that cells could grow at normal rates without being glycolytic. We then proceeded to characterise the stem cell population of breast cancer cells using the mammosphere assay. Strikingly, this study demonstrated that MCF-7 cells are able to adapt to fructose conditions, proliferate in a programmed manner as glucose adapted cells, and significantly form more mammospheres than more glycolytic cells. This indicates that the CSLCs do not require a high rate of glycolysis to survive as long as they have sufficient substrate to grow. Moreover, it was found that SOX2 is more highly expressed in glycolysis restricted conditions and OCT4A is not present in breast cancer cell lines. OCT4 PG1 was expressed in some breast cancer cell lines (MCF-7), implying a possible role in carcinogenesis. Additionally, targeting different metabolic pathways found that the use of oxamate to inhibit glycolysis showed that glycolysis is not a critical metabolic pathway for CSLC activity in fructose adapted cells. In conclusion this work shows important links between glycolytic metabolism and pluripotency, and pluripotency related genes in breast cancer.<br/
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