105,752 research outputs found

    THE EDUCATION AND THE DEMANDS OF LABOUR MARKET

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    In the present study the author intend to discuss the role of education in economy and the relationship between education and the current state of Hungarian labor market. Education became one of the largest sub-systems of modern societies in the past century. One of the most important endeavors of employment policy, according to Galasi, is to establish stronger harmony between training and employment. The key for the reduction of unemployment is that training should better serve labor market demands. We are astoundingly under informed about how a degree is exploited on the labor market, what is the expected time of the return of a certain qualification, and which degrees do not prevail without the return of investment.role of education, Hungary, problems, Labor and Human Capital, Teaching/Communication/Extension/Profession,

    A revision of the Bracon Fabricius species in Wesmael’s collection deposited in Brussels (Hymenoptera: Braconidae: Braconinae)

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    An account of the taxonomic position of the genus Bracon Fabricius, 1804 is presented. In his monograph Wesmael (1838: 7-58) made a survey of 48 nominal species of Bracon occurring in Belgium. Out of the 48 species thirty-seven were described by Wesmael himself as new species, eleven more species had previously been described by Fabricius (three species), Nees (seven species) and Spinola (one species). The Bracon material studied by Wesmael is deposited in the Royal Belgian Institute of Natural Sciences, Brussels. Type (holo-, lecto-, paralectotype) designations are made for Wesmael’s species and neotype designations for Nees sensu Wesmael’s species. Redescriptions, comments on distributions and their taxonomic positions are presented. Palpibracon subgen. nov. is established (type species Bracon delibator Haliday, 1833) for fi ve Bracon species with long maxillary palpi in the Holarctic (four species) and Ethiopian Region (one species). The following fifteen Bracon species names proved to be junior synonyms (valid names in italics): B. dichromus Wesmael, 1838 = B. carpaticus Niezabitowski, 1910 syn. nov.; B. erraticus Wesmael, 1838 = B. bellicosus Papp, 1971 syn. nov., = B. exarator Marshall, 1885 syn. nov., = B. praetermissus Marshall, 1885 syn. nov., B. vectensis Marshall, 1885 syn. nov.; B. fuscicornis Wesmael, 1838 = B. levicarinatus Niezabitowski, 1910 syn. nov.; B. immutator Nees, 1834 = B. breviusculus Wesmael, 1838 syn. nov.; B. intercessor Nees, 1834 = B. laetus Wesmael, 1838 syn. nov.; B. larvicida Wesmael, 1838 = B. crassiusculus Szépligeti, 1901 syn. nov.; B. longicollis Wesmael, 1838 = B. subcylindricus Wesmael, 1838 syn. nov.; B. megapterus Wesmael, 1838 = B. biimpressus Telenga, 1936 syn. nov.; B. nigratus Wesmael, 1838 = B. orbicularis Niezabitowski, 1910 syn. nov.; B. osculator Nees, 1811 = B. coniferarum Fahringer, 1927 (Schmiedeknecht in litt.) syn. nov.; B. picticornis Wesmael, 1838 = B. vitripennis Ratzeburg, 1852 syn. nov.; B. titubatus Wesmael, 1838 = B. fuscipennis Wesmael, 1838 syn. nov. The species Bracon (Lucobracon) turolus Papp, 1984 is revalidated (suppressed under the name B. (Glabrobracon) nigriventris Wesmael, 1838 by Tobias & Belokobylskij 2000: 162). A historic discussion of the subgeneric division of the Bracon species is given

    Uncobracon Papp 1996

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    Genus <i>Uncobracon</i> Papp <p> <i>Uncobracon</i> Papp, 1996: 168 (type species: <i>Bracon apoderi</i> Watanabe). Tobias & Belokobylskij, 2000: 119 (in key, as a subgenus of <i>Bracon</i>). Tan <i>et al.</i>, 2012: 64 (as a valid genus).</p>Published as part of <i>Samartsev, Konstantin G., 2018, New species of the subfamily Braconinae (Hymenoptera: Braconidae) from the Russian Far East, pp. 238-254 in Zootaxa 4388 (2)</i> on page 249, DOI: 10.11646/zootaxa.4388.2.6, <a href="http://zenodo.org/record/1187334">http://zenodo.org/record/1187334</a&gt

    Potential bulged G-quadruplex forming sequences (pG4-BS) in the human genome

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    Dataset containing the genomic coordinates of potential bulged G-quadruplex forming sequences (pG4-BS) in the human genome (Assembly: GRCh38). G-quadruplexes (G4s) are non-canonical DNA structures that are commonly found in single-stranded DNA (e.g., during transcription and replication). "Canonical" G4 finding algorithms have existed for a number of years and these utilize a generalized sequence model (G3+N1-7G3+N1-7G3+N1-7G3+; where "G3+" denotes a cluster of at least 3 continuous guanines and "N1-7" denotes any combination of one to seven nucleotides) to capture potential G4 forming DNA regions. Bulged G4s represent a novel subset of G4-like structures that incorporate non-guanine nucleotide(s) into one or more of their guanine clusters. Due to the highly diverse nature of the DNA sequence underlying these structures, no genome wide maps of pG4-BS are available for any organisms. Here, we provide a computationally derived dataset containing the genomic coordinates of pG4-BS in the human genome

    Potential bulged G-quadruplex forming sequences (pG4-BS) in the human genome

    No full text
    Dataset containing the genomic coordinates of potential bulged G-quadruplex forming sequences (pG4-BS) in the human genome (Assembly: GRCh38). G-quadruplexes (G4s) are non-canonical DNA structures that are commonly found in single-stranded DNA (e.g., during transcription and replication). "Canonical" G4 finding algorithms have existed for a number of years and these utilize a generalized sequence model (G3+N1-7G3+N1-7G3+N1-7G3+; where "G3+" denotes a cluster of at least 3 continuous guanines and "N1-7" denotes any combination of one to seven nucleotides) to capture potential G4 forming DNA regions. Bulged G4s represent a novel subset of G4-like structures that incorporate non-guanine nucleotide(s) into one or more of their guanine clusters. Due to the highly diverse nature of the DNA sequence underlying these structures, no genome wide maps of pG4-BS are available for any organisms. Here, we provide a computationally derived dataset containing the genomic coordinates of pG4-BS in the human genome

    Potential bulged G-quadruplex forming sequences (pG4-BS) in the human genome

    No full text
    Dataset containing the genomic coordinates of potential bulged G-quadruplex forming sequences (pG4-BS) in the human genome (Assembly: GRCh38). G-quadruplexes (G4s) are non-canonical DNA structures that are commonly found in single-stranded DNA (e.g., during transcription and replication). "Canonical" G4 finding algorithms have existed for a number of years and these utilize a generalized sequence model (G3+N1-7G3+N1-7G3+N1-7G3+; where "G3+" denotes a cluster of at least 3 continuous guanines and "N1-7" denotes any combination of one to seven nucleotides) to capture potential G4 forming DNA regions. Bulged G4s represent a novel subset of G4-like structures that incorporate non-guanine nucleotide(s) into one or more of their guanine clusters. Due to the highly diverse nature of the DNA sequence underlying these structures, no genome wide maps of pG4-BS are available for any organisms. Here, we provide a computationally derived dataset containing the genomic coordinates of pG4-BS in the human genome

    Pergalumna (Bigalumna) Mahunka & Mahunka-Papp 2009, stat. nov.

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    Pergalumna (Bigalumna) Mahunka & Mahunka-Papp, 2009 stat. nov. (Figs 1–3) Pergalumna (Bigalumna) rimosa (Mahunka & Mahunka-Papp, 2009) comb. nov. The subgenus Galumna (Bigalumna) was proposed by Mahunka and Mahunka-Papp (2009) with Galumna (Bigalumna) rimosa (Mahunka & Mahunka-Papp, 2009 as type species from Kenya. These authors included this subgenus in the genus Galumna Heyden, 1826. However, all representatives of the latter genus have lamellar setae inserted between lamellar and sublamellar lines. We studied the morphology of paratypes of G. (B.) rimosa and clarified that lamellar setae are inserted between lamellar lines, and generally, this species has all typical characteristics of the genus Pergalumna Grandjean, 1936. Based on the above statement and generic diagnosis of Pergalumna (see Ermilov et al. 2013), we propose the following taxonomic alterations: a) Pergalumna (Bigalumna) Mahunka & Mahunka-Papp, 2009 stat. nov., b) Pergalumna (Bigalumna) rimosa (Mahunka & Mahunka-Papp, 2009) comb. nov.Published as part of Ermilov, Sergey G. & Bayartogtokh, Badamdorj, 2015, Systematic placement of some taxa in the family Galumnidae (Acari, Oribatida), pp. 489-493 in Zootaxa 3964 (4) on page 490, DOI: 10.11646/zootaxa.3964.4.8, http://zenodo.org/record/23768

    Micrepimera pandastica Ševčík & Papp, 2011, sp. n.

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    Micrepimera pandastica sp. n. (Figs. 10–20) Type material. Holotype male: VIETNAM, Bac Kan Prov., Ba Be NP, Na Mam, forest in the gorge behind the NP HQ, UV light trap, Apr 17 -19, 2010, 22.417137 o N 105.632505 o E, 200m, VN 2010 PL_ 17, leg. Papp, L., Peregovits, L., Soltész, Z. & Lengyel, G. (HNHM). Paratypes: 1 male: VIETNAM, Bac Kan Prov., Ba Be NP, NP headquarters, at light, 240 m, Apr 16 -19, 2010 - 20.4180798 o N 105.6336528 o E, VN 2010 PL_ 12, leg. Papp, L., Peregovits, L., Soltész, Z. & Lengyel, G. (HNHM). 2 males: VIETNAM, Bac Kan Prov., Ba Be NP, Na Mam, at light, 187 m, Apr 17 -18, 2010, VN 2010 PL_ 16, 22.411612 o N 105.626792 o E, leg. Papp, L., Peregovits, L., Soltész, Z. & Lengyel, G. (HNHM, SMOC). 1 male: VIETNAM, Bac Kan Prov., Ba Be NP, Na Mam, forest in the gorge behind the NP HQ, UV light trap, Apr 17 -19, 2010, 22.417137 o N 105.632505 o E, 200m, VN 2010 PL_ 17, leg. Papp, L., Peregovits, L., Soltész, Z. & Lengyel, G. (SMOC). Diagnosis. A remarkably bicoloured, black and white macrocerine fungus gnat (Fig. 10). Antennae mostly white, with dark distal bands on flagellomeres 1 to 10. Flagellomeres 11 to 14 remarkably thin, narrowing gradually. In this respect M. pandastica is similar to M. punctipennis (see fig. 414 of Matile, 1990). Head, thorax and coxae black, abdomen black with white lateral spot on tergite 3 and 4. Wing pattern similar to that of M. punctipennis but the markings are more distinct and dark. The subapical dark spot extended to the tips of M 1 and M 2. Additional dark areas (not present in punctipennis) are along the apical parts of veins A 1, CuP, CuA 1, CuA 2 and above base of CuA 1. Vein A 1 reaching wing margin. Fore femur with a comb of short seteae medioventrally. Apical spurs on mid and hind tibia absent. Gonocoxites fused only basally. Cerci and proctiger different from those of M. berentiana (cf. Fig. 5 and 16; figures by Matile 1990 of the terminalia of M. punctipennis are not detailed enough). Gonostylus relatively broad with a short dark apex and with numerous long setae. Contours of gonostylus rather similar to that of M. punctipennis (cf. figs 417–418 of Matile 1990). Description. Male. Measurements in mm (holotype): body length 6.2, wing length 3.80, wing width 1.27 (ratio of length to width 2.99). Head. Blackish brown. Compound eyes large, covering almost all the head from lateral view, shortly pubescent. Cerebral sclerite separated from the frons by a membraneous area reaching laterally above the eyes. Anterior edge of cerebral sclerite medially slightly excavated. Three ocelli in triangular position on anterior half of cerebral sclerite. Distinct sagittal furrow in its posterior half. Antenna with 14 flagellomeres, of which the basal 10 flagellomeres are bicoloured (Figs 12, 13), with apical halves dark. Scape and pedicel similar to those of M. berentiana. Flagellomeres 1 to 9 normal, long, cylindrical (i.e. not compressed laterally), flagellomere 10 narrowing apically, flagellomeres 11 to 14 remarkably thin, narrowing gradually. Flagellum with several setae distinctly longer than the width of the flagellum, particularly so for the apical ones. Palpus (Fig. 14) with first palpomere much longer than broad and third palpomere rather globular, i.e. about as long as broad. Thorax. All blackish brown. Scutum with two rows of dorsocentral setae and laterally with prealar and postalar setae. Scutellum dark brown, with a transverse row of fine subapical setae, without long apical bristles. Mediotergite and laterotergite bare. Anepisternum with a dense patch of setae along the anterodorsal margin. Preepisternum 2 bare, dark brown with the upper third pale. Anepimeron small, bare, not reaching between preepisternum 2 and laterotergite. Haltere mostly dark brown, its basal half yellowish. Wing. Hyaline, with distinct dark markings. Membrane covered with microtrichia, without macrotrichia. A dark transverse band in the apical part of wing, reaching from the tip of R 5 to M 1 and M 2 (Fig. 11). A large dark spot over R 4 and two smaller ones on proximal third of both M 1 and M 2. Further dark markings on the branches of Cu and around r-m fusion. C produced beyond R 5 to 3 / 5 of the distance of the tips of R 5 and M 1. Costa, R 1 and R 5 covered with macrotrichia. R 1 ending in C at about half of the length of wing. Radio-median fusion light but traceable. Basal portion of media developed. CuA 1 approaching CuA 2 bellow r-m fusion. CuP fold-like, distinct, long but not reaching wing margin, dark in its distal third. Vein A 1 strong, dark in distal half, reaching wing margin. Legs. Relatively long and narrow, bicoloured (Fig. 10). All coxae and trochanters blackish brown. C 1 covered with setae mainly on front side, C 2 with several setae apically and C 3 with several fine posterolateral setae. Hind coxa widens towards its base. Femora sparsely clothed with fine trichia, not longer than maximum width of femur. Fore femur whitish, darkened only apically, bearing a distinct comb of short seteae medioventrally. Mid and hind femur darkened at distal half. All tibiae light brown with blackish tips, covered with numerous short trichia arranged irregularly. The apex of fore tibia widened, without distinct anteroapical depressed area. Fore tibia with one apical spur, as long as maximum tibial diameter. Both mid and hind tibia apically without spurs, at most with several slightly longer trichia. The first tarsomere slightly longer than tibia in all legs. Abdomen. Almost all brownish black (Fig. 10). Tergites 3 and 4 laterally with a white spot near the anterior margin. Terminalia dark with light gonostyli. Terminalia (Figs 15–20) are rather specific. Tergite 9 (Fig. 15) much broader than long, anterior margin strongly concave. Anterolateral edges with medially curved processes (Figs 15–16). Tergite 9 with several long marginal and discal setae. Cerci and proctiger: apical part not divided, only the short setae may show its original paired structure. Two large basal setose plates present, where the setae are directed medially. Gonocoxites (Fig. 17) fused on a short basal section only, medially with a large opening (less apparent in some paratypes, but this may be due to unequal clearing in KOH) and a pair of large widely rounded well-sclerotised processes, which meet sagittally. Gonocoxal apodeme rather thin (Fig. 19), connecting sclerite without any posterior processes. Gonostylus (Fig. 18) rather broad with a short dark rather sharp apex and with numerous long setae. Inner genitalia (Figs 19- 20) peculiar with 3 sclerites with microscopic longitudinal lines (sagittal one may be the distiphallus). Female. Unknown. Biology. Unknown. The type specimens were captured at light in limestone forests of northern Vietnam. Etymology. The specific name (adjective) is a wordplay—a combination of “ panda “ and “ fantastica “, referring to the unusual coloration of the new species.Published as part of Ševčík, Jan & Papp, László, 2011, New Afrotropical and Oriental species of Micrepimera Matile (Diptera: Keroplatidae), pp. 58-66 in Zootaxa 3128 on pages 61-65, DOI: 10.5281/zenodo.20240

    p53 regulates PAPP-A levels.

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    <p>A) HBL-100 cells express wild type p53, while HS578T cells express mutant p53. The levels of PAPP-A mRNA in these cell lines were determined by qRT-PCR. B) Western blot of the levels of p53 in HBL-100 and HS578T cells. C) the expression of p53 was inhibited in HBL-100 cells using siRNA and the PAPP-A mRNA levels were determined by qRT-PCR. D) the efficiency of siRNA against p53 was determined by western blot. E) the expression of p53 was inhibited in HS578T cells using siRNA and the PAPP-A mRNA levels were determined by qRT-PCR. F) the inhibition of p53 by siRNA in HS578T cells was monitored by western blot. G) Duplicate human breast carcinoma tissue microarray slides (Zymed) were stained by IHC using the DO1 antibody against p53 and the rabbit polyclonal antibody against PAPP-A (Dako). H) The percentage of tumors positive for p53, PAPP-A or both was determined.</p
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