1,721,375 research outputs found
A new pleiotropic effect of statins in elderly: Modulation of telomerase activity
No full textRecent evidence suggests a link between statins and telomere biology. Whether statin treatment may modulate telomerase activity and affect telomere erosion rate is unknown. We aimed at investigating the potential impact of statin therapy on peripheral blood mononuclear cells telomerase activity, its implication on LTL variability, and its association with telomere shortening rates along with aging. The cross-sectional study was conducted in 230 subjects (age range: 30-86 y) stratified according to statins treatment. LTL was measured by quantitative polymerase chain reaction and telomerase activity by a PCRELISA protocol. Subjects on statin treatment showed higher telomerase activity (P<0.0001) and longer LTL (P=0.028) levels compared to the nonstatin group. Statin therapy was associated with higher telomerase activity independently of multiple covariates, including age, gender, smoking habits, lipid, systemic inflammation, glucose, and blood pressure levels (P=0.019). Indeed, subjects on statin treatment showed significant lower telomere erosion along with aging. Every 1 y increment in age, LTL decreases by 0.058 Kb in no statin and 0.033 Kb in statin groups, respectively, as well as the major difference in telomere attrition between groups was found after the age of 65 yr (P<0.0001). In summary, statins, modulating telomerase activity, affect telomere erosion along with aging.-Boccardi, V., Barbieri, M., Rizzo, M. R., Marfella, R., Esposito, A., Marano, L., Paolisso, G. A new pleiotropic effect of statins in elderly: modulation of telomerase activit
Telomerase activation: A potential key modulator for human healthspan and longevity
No full textThe elderly population is increasing progressively. Along with this increase the number of age related diseases, such as cardiovascular, neurodegenerative diseases, metabolic impairment and cancer, is also on the rise thereby negatively impacting the burden on health care systems. Telomere shortening and dysfunction results in cellular senescence, an irreversible proliferative arrest that has been suggested to promote organismal aging and disabling age-related diseases. Given that telomerase, the enzyme responsible for maintaining telomere lengths, is not expressed at levels sufficient to prevent telomere shortening in most of our cells, telomeres progressively erode with advancing age. Telomerase activation, therefore, might serve as a viable therapeutic strategy to delay the onset of cellular senescence, tissue dysfunction and organismal decline. Here we analyze the more recent findings in telomerase activation as a potential key modulator for human healthspan and longevity
Population aging: Results of ARNO study
No full textPopulation aging occurs when the median age of a country or region rises due to the elongation of life expectancy and birth rate reduction. The aging process and its effects on the structure of the Italian population is currently in the spotlight. The Italian National Institute of Statistics, ISTAT, has predicted a high rise in the life expectancy of Italian residents, increasing from 77.4 years of age to 83.6 years in 2050 for men and from 83.3 years of age to 88.6 years for women. Thus, Italy will have to face with many aging consequences such as increasing in money spending on healthcare. Here we report the results of the ARNO study which represents a very effective tool for the elderly population evaluation and health needs assessment
Impact of Sex Differences in Incident and Recurrent Coronary Events and All-Cause Mortality
No full textPerspective: Dietary Protein Needs of Elderly People: Protein Supplementation as an Effective Strategy to Counteract Sarcopenia
No full textIL CONTROLLO GLICEMICO NELL’ANZIANO DIABETICO: COSA CI INSEGNANO I RISULTATI DEI TRIALS?
No full textHealthy ageing: what role does metabolism play?
No full textThe process of ageing is associated with progressive metabolic remodelling, which mainly affects anthropometric, endocrine and metabolic parameters. Although it occurs successfully in some individuals, in others it fails.
Centenarians in good health are a very select group of subjects representing an exceptional condition. How centenarians achieve an extended human lifespan is not known. In order to assess the relationship between healthy ageing and metabolism, age-related metabolic changes in elderly subjects have been studied using different techniques in both animals and humans. Several studies in humans have shown that longevity is associated with significantly improved glucose handling — primarily a rise in insulin sensitivity and a decline in plasma insulin-like growth factor-I. Calorie restriction seems to be the best positive modulator of metabolism favouring longevity. In addition, specific metabolic adaptations — possibly genetic — may occur in those reaching healthy, extreme old age
Impact of diabetes mellitus on clinical outcomes in patients affected by Covid-19
No full textA possible association could exist between type 2 diabetes mellitus (T2DM) and Coronavirus-19 (Covid-19) infection. Indeed, patients with T2DM show high prevalence, severity of disease and mortality during Covid-19 infection. However, the rates of severe disease are significantly higher in patients with diabetes compared with non-diabetes (34.6% vs. 14.2%; p < 0.001). Similarly, T2DM patients have higher rates of need for Intensive Care Unit (ICU, 37.0% vs. 26.7%; p = 0.028). Thus, about the pneumonia of Covid-19, we might speculate that the complicated alveolar-capillary network of lungs could be targeted by T2DM micro-vascular damage. Therefore, T2DM patients frequently report respiratory symptoms and are at increased risk of several pulmonary diseases. In addition, pro-inflammatory pathways as that involving interleukin 6 (IL-6), could be a severity predictor of lung diseases. Therefore, it looks intuitive to speculate that this condition could explain the growing trend of cases, hospitalization and mortality for patients with T2DM during Covid-19 infection. To date, an ongoing experimental therapy with monoclonal antibody against the IL-6 receptor in Italy seems to have beneficial effects on severe lung disease and prognosis in patients with Covid-19 infection. Therefore, should patients with T2DM be treated with more attention to glycemic control and monoclonal antibody against the IL-6 receptor during the Covid-19 infection
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