867 research outputs found
Interpretasi aksi teo-ecology dan transendentalisme terhadap pelestarian lingkungan
No full textThis research presents a reading of the aspects of religious transidentalism in presenting the narrative of environmental preservation. Certainly in that context, the author tries to illustrate with teo-ecology construction based on quranic insights. Therefore, man as a subject, occupies a wide space in realizing the idea of godliness and humanistics in managing the nature and environment that God has given. Result of this study provides a major argument against the meaning of the Quran as the basis of environmental Teo-Ecology which contributes the deepest contribution, so that environmental preservation is always encouraged. In addition, in environmental preservation is necessary also the construction of ecological ethics humanizes the environment itself, so that a balance arises there. Lastly, it is no less important to elicit an attitude of transcendentalism in man that as god's representative on Earth must have mentally managed the environment well
Massimo Cacciari y la onto-teo-logía
No full textEs tracta de presentar a un autor com Massimo Cacciari en el marc del que Heidegger va anomenar onto-teo-logia com aquella manera d’interpretar el pensament filosòfic (ontològic) i teològic des de els inicis de la filosofia fins a Nietzsche. Heidegger insisteix al llarg de la seva obra en allò que ha quedat per pensar: l’Ésser. Subratlla aquesta carència com quelcom que afecta al destí de l’ésser i a la pròpia finitud humana. La tradició ha deixat ‘impensada’ la diferència de l’ésser de l’existent i l’existent. Aquesta carència demana, per tant, un ‘pas enrere’ en el que situar de bell nou a la ‘metafísica’. Cacciari es situa en el mateix punt de partida que Heidegger, però el filòsof italià explora una via que va ser pràcticament oblidada per Heidegger: el neoplatonisme. Al llarg d’aquesta investigació veurem, per tant, com els màxims representants del que Heidegger va anomenar onto-teo-logia son tornats a pensar des de una òptica ‘nova’ per Massimo Cacciari. El nihilisme detectat per Heidegger com l’encadenament d’una ‘metafísica general’ i una ‘metafísica especial’ pot ser revisat des dels comentaris al Parmènides de Plató de la gran tradició neoplatònica. Cacciari comença des de Kant per, en una mena de regressió en el temps, tornar a aquell lloc que la filosofia reclama com ‘amor al Bé’ i que la Crítica kantiana hauria menyspreat com una ‘volada cap a un lloc ignot’. Es tracta de reivindicar, al parer de Cacciari, el lloc de la intuïció filosòfica sense oblidar el que el mateix Heidegger ja va detectar com a paradigma onto-teo-lògic. La teologia, des d’aquesta perspectiva neoplatònica, pot ser revisada per convertir-se en una digne dialogant de la filosofia. Els desenvolupaments teològics no poden ser entesos sense el que el neoplatonisme va plantejar en el seu insistent desenvolupament de les apories del Parmènides. L’idealisme post-kantià (Hegel, Fichte) es ‘criticat’ i rebutjat des de la filosofia positiva de Schelling.
També presentem en aquest treball la crítica d’Emmanuel Levinas a un pensament sobre Déu en els termes en els que Heidegger el va presentar, és a dir, un Déu pensat només en els termes de la onto-teo-logia. La present investigació es divideix, per tant, en dos parts fonamentals: Heidegger i el paradigma onto-teo-lògic com el desenvolupament especulatiu del nihilisme i la alternativa que E. Levinas proposa a aquest plantejament per considerar una possibilitat no ontològica sobre un pensament sobre Déu (l’Altre): una possibilitat ètica (el rostre de l’altre des del que ‘veure’ l’Altre) i una segona part on presentem la trilogia fonamental de Cacciari (Dell’Inizio, Della Cosa Ultima i Labirinto Filosofico) com a interrogació ‘especulativa’ de tall neoplatònic del paradigma detectat per Heidegger.
He afegit tres apèndixs que intenten posar de relleu altres maneres d’enfocar el tema plantejat. Un apèndix dedicat al pensament del teòleg Zizioulas, un segon apèndix dedicat a les objeccions que va suscitar l’obra (Dell’Inizio) de Cacciari a Itàlia i un altre dedicat al plantejament tomista sobre el tema des de l’òptica de E. Gilson.Se trata de presentar a un autor como Massimo Cacciari enmarcándolo en lo que Heidegger llamó la onto-teo-logía como aquella manera de interpretar el pensamiento filósófico (ontológico) y teológico desde los albores de la filosofía hasta Nietzsche. Heidegger insiste a lo largo de su obra en aquello que ha quedado ‘impensado’: el Ser. Subraya esta carencia como algo que afecta al destino del ‘ser’ y a la propia finitud humana. La tradición ha dejado ‘impensada’ la diferencia del ser del ente y el ente. Esta carencia requiere, por tanto, un ‘paso atrás’ en el que situar de nuevo a la ‘metafísica’. Cacciari se situa en el mismo punto de partida del que Heidegger partió, pero el filósofo italiano explora una vía que fue prácticamente olvidada por Heidegger: el neoplatonismo. A lo largo de esta investigación veremos, por tanto, como los máximos representantes de lo que Heidegger llamó onto-teo-logía son repensados desde una óptica ‘nueva’ por Massimo Cacciari. El nihilismo detectado por Heidegger como el encadenamiento de una ‘metafísica general’ y una ‘metafísica especial’ puede ser revisado desde los comentarios al Parménides de Platón de la gran tradición neoplatónica. Cacciari parte de Kant para, en una especie de regresión en el tiempo, volver a aquel lugar que en filosofía se reclama como ‘amor al Bien’ y que la Crítica kantiana habría despreciado como un ‘vuelo hacia un lugar ignoto’. Se trata de reivindicar, al parecer de Cacciari, el lugar de la intuición filosófica sin olvidar lo que el mismo Heidegger ya detectó como pardigma onto-teo-lógico. La teología, vista desde esta vertiente neoplatónica, puede ser revisitada para ser una ‘digna’ dialogante de la filosofía. Los desarrollos teológicos no pueden ser entendidos sin lo que el neoplatonismo planteó en su insistente desarrollo de las aporías del Parménides. El idealismo post-kantiano (Hegel, Fichte) es ‘criticado’ y ‘rechazado’ desde la filosofía positiva de Schelling.
Presentamos además la crítica de Emmanuel Levinas a un pensamiento sobre Dios en los términos en los que Heidegger lo presentó, es decir, un Dios sólo pensado en los términos de la onto-teo-logía. La presente investigación se divide, por tanto, en dos partes fundamentales: Heidegger y el paradigma onto-teo-lógico como el desarrollo especulativo del nihilismo y la alternativa que E. Levinas propone a tal planteamiento por considerar una posibilidad no ontológica sobre un pensamiento sobre Dios (el Otro): una posibilidad ética (el rostro del otro desde el que ‘ver’ al Otro) y una segunda parte donde presentamos la trilogía fundamental de Cacciari (Dell’Inizio, Della Cosa Ultima y Labirinto Filosofico) como un cuestionamiento ‘especulativo’ de corte neoplatónico del paradigma detectado por Heidegger.
He añadido tres apéndices que intentan poner de relieve otros modos de enfocar el tema planteado. Un apéndice dedicado al pensamiento del teólogo Zizioulas, un segundo apéndice dedicado a las objeciones que suscitó la obra (Dell’Inizio) de Cacciari en Italia y otro dedicado al planteamiento tomista sobre el tema desde la óptica de E. Gilson.It is my intention to present author Massimo Cacciari in relation to what Heidegger called onto-theo-logy, as one way of interpreting the philosophical (ontological) and theological thinking, from the dawn of philosophy to Nietzsche. Heidegger insists throughout his work on what has been “unthinkable”, that is to say, the Being. The philosopher emphasises this lack as something that affects the fate of the “being” and our human finitude. The tradition has left behind a gap, in terms of the difference between the being entity and the entity itself. This deficiency requires, therefore, a 'step back' in order to place 'metaphysics' again. Cacciari is positioned at the same starting point from which Heidegger departed, but the Italian philosopher explores a way that was almost forgotten by Heidegger: Neoplatonism. Throughout this investigation we will see, therefore, how the main referents of what Heidegger called onto-theo-logy are studied from a 'new' perspective by Massimo Cacciari. The nihilism detected by Heidegger as the continuum of 'general metaphysics' and 'special metaphysics' can be revised from the comments on Plato's Parmenides in the great neoplatonic tradition. Cacciari departs from Kant, in a sort of regression in time, back to the common place that in philosophy is defined as 'love of the Good' and Kant's Critique would have despised as a «flight to nowhere». We intend to claim, pointing at Cacciari's particular perception, the place for philosophical intuition, while taking into account what Heidegger himself conceived as the onto-theo-logical paradigm. Theology, viewed from this neoplatonic perspective, may be revisited to become a dialogical counterpart of philosophy. These theological developments cannot be understood without the insistent advances raised by Neoplatonism in the paradoxes of Parmenides. The post-Kantian Idealism (Hegel, Fichte) is 'criticized' and 'rejected' from the positive philosophy of Schelling.
We present here, furthermore, Emmanuel Levinas's criticism of the thinking about God in the way Heidegger had submitted it, that is to say, a God thought only in onto-theo-logical terms. This research will, therefore, consist of two major parts: Heidegger and the onto-theo-logical paradigm, as the speculative proposal of nihilism and the alternative proposed by E. Levinas, where he suggests a non-ontological approach to the idea of God (the Other one), i.e., an ethical approach (the face of someone else from which we can see the Other one); and a second part, where we will introduce the basic trilogy of Cacciari (Dell'Inizio, Della Cosa Ultima and Labirinto Filosofico), as a speculative neoplatonic questioning of the paradigm posited by Heidegger.
Finally, we have added three appendices with the attempt to emphasize other possible approaches to the issue proposed. An appendix is devoted to the thought of theologian Zizioulas; a second appendix deals with the objections raised to Cacciari's work, Dell'Inizio, in Italy; and the final appendix is devoted to the Thomist approach to our issue from E. Gilson's perspective
Overcoming the biological barriers to intravenous delivery of stem cells and drugs for the treatment of vascular-related diseases
No full textDefective vasculature is one of the hallmarks of many diseases ranging from restricted blood flow in ischemia to abnormal blood vessel growth in cancer. Intravenous administration is particularly beneficial to patients with vascular-related diseases which are not easily accessible by the conventional methods. Therapeutics delivered via this route, however, must overcome the barriers along the way from the entry into the bloodstream to the target destination. To maximize the therapeutic efficacy, this dissertation investigates the use of polymeric nanoparticles to improve the transport of intravenously administered therapeutics and their accumulation in the diseased sites.
The first part of this dissertation focuses on the delivery of mesenchymal stem cells to ischemic tissue. Chapter 2 presents the use of nanoparticles capable of enhancing the ability of stem cells to migrate across defective vascular walls. The surface of stem cells was tethered with particles that sustainably released stromal cell-derived factor-1α. Intravenously injected stem cells consequently exhibited a higher migration ability to ischemic muscle. The strategy of surface tethering was then applied towards protecting stem cells in the oxidative diseased sites, as presented in Chapter 3. The nanoparticles are devised to rapidly discharge antioxidant epigallocatechin gallate in response to elevated levels of hydrogen peroxide. The stem cells survived in sub-lethal concentrations of hydrogen peroxide and maintained their angiogenic potential in vivo.
The second part of this dissertation looks at the delivery of doxorubicin to cancer cells. Chapter 4 presents the design strategies of nanoparticles for an enhanced release of entrapped doxorubicin within cancer cells. By incorporating moieties sensitive to the intracellular signals of cancer cells, drug release from the particles was significantly accelerated, giving rise to superior in vivo antitumor efficacy. Ultimately, the results of this dissertation will greatly contribute to improving the therapeutic outcome of numerous vascular-related diseases.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2020-08-01The student, Jyeyng Teo, accepted the attached license on 2018-07-02 at 15:47.The student, Jyeyng Teo, submitted this Dissertation for approval on 2018-07-02 at 16:05.This Dissertation was approved for publication on 2018-07-06 at 08:58.DSpace SAF Submission Ingestion Package generated from Vireo submission #12703 on 2018-09-27 at 11:34:02Made available in DSpace on 2018-09-27T16:47:16Z (GMT). No. of bitstreams: 2
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The parametric nature of two students’ covariational reasoning
No full textResearchers have argued that covariational reasoning is foundational for learning a variety of mathematics topics. We extend prior research by examining two students’ covariational reasoning with attention to the extent they became consciously aware of the parametric nature of their reasoning. We first describe our theoretical background including different conceptions of covariation researchers have found useful when characterizing student reasoning. We then present two students’ activities during a teaching experiment in which they constructed and reasoned about covarying quantities. We highlight aspects of the students’ reasoning that we conjectured created an intellectual need that resulted in their constructing a parameter quantity or attribute, a need we explored in closing teaching episodes. We discuss implications of these results for perspectives on covariational reasoning, students’ understandings of graphs and parametric functions, and areas of future research
Transcranial magnetic stimulation: From neurophysiology to pharmacology, molecular biology and genomics
No full textNoninvasive plasticity paradigms, both physiologically induced and artificially induced, have come into their own in the
study of the effects of genetic variation on human cortical plasticity. These techniques have the singular advantage that
they enable one to study the effects of genetic variation in its natural and most relevant context, that of the awake
intact human cortex, in both health and disease. This review aims to introduce the currently available artificially induced
plasticity paradigms, their putative mechanisms—both in the traditional language of the systems neurophysiologist and
in the evolving (and perhaps more relevant for the purposes of stimulation genomics) reinterpretation in terms of
molecular neurochemistry, and highlights recent studies employing these techniques by way of examples of applications.Noninvasive plasticity paradigms, both physiologically induced and artificially induced, have come into their own in the study of the effects of genetic variation on human cortical plasticity. These techniques have the singular advantage that they enable one to study the effects of genetic variation in its natural and most relevant context, that of the awake intact human cortex, in both health and disease. This review aims to introduce the currently available artificially induced plasticity paradigms, their putative mechanismsĝ€"both in the traditional language of the systems neurophysiologist and in the evolving (and perhaps more relevant for the purposes of stimulation genomics) reinterpretation in terms of molecular neurochemistry, and highlights recent studies employing these techniques by way of examples of applications. © The Author(s) 2010
Modeling Penicillium Expansum Growth Response to Thyme Essential oil at Selected Water Activities and pH Values Using Surface Response Methodology
No full textAbstractOur objective was to evaluate, using a full factorial design, the effects of selected water activities (0.990, 0.945, or 0.900), pHs (5, 4, or 3), and thyme essential concentration (TEO, 0, 25, 50, or 100ppm) oil on Penicillium expansum lag time (λ) and radial growth rate (μm) obtained by modeling mold response using Gompertz equation, and corresponding polynomial quadratic models. Potato-dextrose agar formulated with every studied factor combination was inoculated with 103 spores/ml, and incubated at 25°C up to 30 days. Mold colony diameter was periodically measured during incubation and adjusted with Gompertz equation to determine λ and μm. Decreasing aw and pH, and increasing TEO concentration decreased μm and increased λ. At low aw and pH, the increase in TEO concentration had a dramatic effect on P. expansum response since 25ppm of TEO inhibited its growth for 30 days at 25°C. Gompertz parameters exhibited that P. expansum was sensitive to the evaluated combined factors, allowing us to construct a secondary predictive growth model. TEO in combination with aw and pH reduction effectively inhibited P. expansum growth
One-Dimensional Helical Metal Coordination Polymer: Synthesis and Structure of Infinite Chain of [Ag-7(S2CNEt2)(6)](n)(+) (as [SbF6](-) salt) Composed of Ag-6(S2CNEt2)(6) Cluster Units Linked by Ag(I) Ions via Peculiar Chelating S-S Bites
No full textA new polymeric silver cluster, formulated as [Ag-7(S2CNEt2)(6)][SbF6] (1) was synthesized and characterized by single-crystal X-ray crystallography. The structure can be described as an infinite cationic polymeric helical chain consisting of two [Ag-6(S2CNEt2)(6)] clusters linked by a silver ion tetrahedrally coordinated with four sulfur atoms, two from each of the constituent clusters. The stereochemistry of 1 is classified as a new zeta-modification of silver dithiocarbamate cluster. It is suggested that the constituent [Ag-6(S2CNEt2)(6)] clusters in 1 can be used as building blocks in the construction of 1-D cluster-based metal coordination polymers as well as 2-D or 3-D cluster-based metal-organic frameworks.NNSFC [21071117, 21471125]; iChEM, Xiamen UniversitySCI(E)ARTICLE31163-11782
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