1,721,012 research outputs found
Integrating Absolute Sustainability and Social Sustainability in the Digital Product Passport to Promote Industry 5.0
Full text linkThe establishment of the digital product passport is regarded to be a prominent tool to promote environmental and social sustainability, thus enabling the transition towards Industry 5.0. In this way, it represents a holistic tool for the decision-making process of several actors of a product’s value chain. However, its development is still ongoing and the absolute perspective of environmental sustainability and the social sustainability have been overlooked. The present work aims to fill these gaps and complement the literature currently available on the digital product passport with a threefold purpose. Firstly, by referring to social life cycle assessment methodologies, useful social indicators to include in the digital product passport are discussed and proposed. Secondly, the need for an absolute perspective of environmental sustainability that respects the natural limits of our planet is presented; based on the LCA methodology and the Planetary Boundaries framework, environmental attributes and environmental impact indicators with the corresponding threshold are proposed to be included in the passport and enable the so-called absolute environmental sustainability assessment of products. Finally, a framework based on a cyber-physical system for filling in the digital product passport throughout a product lifecycle is conceived. This work represents an example of how the hallmark technologies of Industry 4.0 can be used towards Industry 5.0
Pulmonary gas exchange and ventilatory efficiency during exercise in health and diseases.
No full textCardiopulmonary exercise testing (CPET) is nowadays used to study the exercise response in healthy subjects and in disease. Ventilatory efficiency is one of the main determinants in exercise tolerance, and its main variables are a useful tool to guide pathophysiologists toward specific diagnostic pathways, providing prognostic information and improving disease management, treatment, and outcome
Exploring glycosyl sulphates as donors for chemical glycosylation
No full textThe preparation of anomeric tetrabutylammonium sulphates of glucose and galactose derivatives is reported and their role as donors in glycosylation reactions is studied. Metal triflates showed good performance in activating sulphate as a leaving group. Among them, ytterbium triflate in stoichiometric amounts gave the best results. Basic conditions using barium oxide in combination with trimethylsilyl trifluoromethanesulfonate (TMSOTf) were also shown to give good results. Benzylated sulphates were much more reactive than benzoylated donors when activated either by ytterbium triflate or by BaO and TMSOTf. Different acceptors were tested, such as isopropanol, cholesterol, and other common sugar derivatives. High reaction rates and excellent glycosylation yields were obtained under mild reaction conditions. The α/β anomeric ratio suggests a predominant SN2-like reaction mechanism
Sweet Boron: Boron-Containing Sugar Derivatives as Potential Agents for Boron Neutron Capture Therapy
Full text linkBoron neutron capture therapy (BNCT) is a binary type of radiotherapy for the treatment of cancer. Due to recent developments of neutron accelerators and their installation in some hospitals, BNCT is on the rise worldwide and is expected to have a significant impact on patient treatments. Therefore, there is an increasing need for improved boron delivery agents. Among the many small molecules and delivery systems developed, a significant amount of recent research focused on the synthesis of boron-containing sugar and amino acid derivatives to exploit specific transport proteins, as d-glucose transporter 1 (GLUT1) and large neutral amino acid transporter (LAT1), overexpressed by tumor cells. This review will discuss the last year’s achievements in the synthesis and some biological evaluation of boronated sugars derivatives. The compounds described in this review are intrinsically asymmetric due to the presence of chiral sugar moieties, often joined to boron clusters, which are structural elements with high symmetry
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Equipment for noninvasive mechanical ventilation.
No full textNoninvasive ventilation consists of the application of a ventilator to the patient’s airways without recourse to orotracheal intubation or tracheostomy and therefore requires a range of devices that guarantee mechanical ventilatory support to the spontaneous pulmonary breathing. Two different types of systems are defined, namely closed and opened, depending on the type of circuit and mask used. Mechanical noninvasive ventilator delivers gas flow through pressured or volumed algorithms as well as in the intensive care unit but often are easier to manage. The importance of a good ventilation is often driven by specialized teamwork by clinicians, nursery, and trained personnel. Communicating and receiving feedback from the patient who needs to undergo a NIV session, if possible, increases compliance and improves the outcome of care significantly. Technical aspects of devices with detailed references to interfaces, management, and prevention of ventilation side effects are reported
Open product development to support circular economy through a material lifecycle management framework
No full textEnvironmental concerns are increasingly demanding for sustainable consumption of Earth's resources. The adoption of the circular economy model can potentially address the environmental sustainability challenge, but there is a need to revolutionise the way products are developed. This work aims to explore the current scientific literature related to the open product development process in support of sustainability, with a major focus on circular economy, and propose a framework to address the main obstacle emerged from it. More than 130 research articles have been scanned, and more than 50 have been deeply analysed. One of the main gaps discovered in the studied literature is the lack of shared information about materials. For this reason, we propose a framework for the establishment of a digital identity of materials by means of cyber-physical systems employed along the material lifecycle. In this way, material-related information in all the lifecycle phases can be collected and stored in a material passport to increase value chain transparency and allow resources traceability. Sharing material passports in a digital platform would form an internet of materials that would support designers and engineers in developing more sustainable products
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