1,721,015 research outputs found
Differential ultrasonic indices of separation distress in the presence and absence of maternal cues in infant rats bred for high and low positive social affect
No full textObjective Preclinical models of human mood disorders commonly focus on the study of negative affectivity, without comparably stressing the role of positive affects and their ability to promote resilient coping styles. We evaluated the role of background constitutional affect of rats by studying the separation and reunion responses of infants from low and high positive affect genetic lines (i.e., differentially selected for High and Low 50 kHz ultrasonic vocalisations (USVs). Methods Infants from Low and High 50 kHz USV breeding lines were isolated from mothers and exposed to either social (familiar or unfamiliar bedding) or neutral (clean bedding) odour cues between two short isolation periods, and tested in homeothermic and hypothermic ambient temperatures. Negative affect was estimated by monitoring separation distress calls (35-45 kHz USVs). Results Low Line pups called at higher rates than High Line, and their rates were stable regardless of odour cue. In contrast, High Line pups increased vocalisations during the second compared with the first isolation periods and during exposure to both familiar and unfamiliar odour cues, but not to neutral odour. Furthermore, the greatest increase in USV emission was seen in the second isolation period following exposure to the unfamiliar odour. However, both lines showed comparable elevated distress USVs to the thermal stressor. Conclusion High Line animals, selected for a positive affective phenotype (50 kHz USVs), exhibited reduced separation anxiety responses in infancy, making this a promising animal model for the role of constitutional affective states in emotional responsivity and potential resilience against emotional disorders. © 2013 Scandinavian College of Neuropsychopharmacology
Neuromodulation of safety and surprise in the early stages of infant development: affective homeostatic regulation in bodily and mental functions
Full text linkDeveloping a sense of internal safety and security depends mainly on others: numerous neuromodulators play a significant role in the homeostatic process, regulating the importance of proximity to a caregiver and experiencing feelings that enable us to regulate our interdependence with our conspecifics since birth. This array of neurofunctional structures have been called the SEPARATION DISTRESS system (now more commonly known as the PANIC/ GRIEF system). This emotional system is mainly involved in the production of depressive symptoms. The disruption of this essential emotional balance leads to the onset of feelings of panic followed by depression. We will focus on the neuropeptides that play a crucial role in social approach behavior in mammals, which enhance prosocial behavior and facilitate the consolidation of social bonds. We propose that most prosocial behaviors are regulated through the specific neuromodulators acting on salient intersubjective stimuli, reflecting an increased sense of inner confidence (safety) in social relationships. This review considers the neurofunctional link between the feelings that may ultimately be at the base of a sense of inner safety and the central neuromodulatory systems. This link may shed light on the clinical implications for the development of early mother-infant bonding and the depressive clinical consequences when this bond is disrupted, such as in post-partum depression, depressive feelings connected to, addiction, neurofunctional disorders, and psychological trauma
Brief periods of positive peer interactions mitigate the effects of total social isolation in young Octodon degus
No full textWe investigated whether positive daily peer-interactions counteract the effects of isolation in Octodon degus. Twenty-five-day-old degus were either isolated (ISO), socially housed (SOCIAL), or isolated and allowed 1-hr daily peer interaction (PARTIAL-ISO). The animals were observed over 4 weeks. Just prior to isolation and after 2 weeks of individual housing, the subjects were assessed for response to pleasant stimuli via a sucrose preference test and to fearful situations in open field and startle tests. Two weeks after the previous tests, the subjects were retested as above and observed in novelty and sociability tests. Only the ISO group showed significant alterations in sensitivity to reward and increased risk-taking behavior in fearful situations. The ISO group consumed more sucrose, spent less time freezing in the startle test and exhibited increased exploration in open field and novelty tests compared to PARTIAL-ISO and SOCIAL groups. In the sociability test, the SOCIAL group vocalized more than the other two groups during encounters with an unfamiliar degus. Our findings suggest that (i) chronic isolation induces alteration of hedonic, emotional and social profiles, with a maturational delay in fear-related responses; (ii) friendly interaction attenuates most behavioral changes induced by total social isolation. However, the positive effects of daily social interactions did not fully counteract deficits in social vocalizations. Our study represents one of the few available studies focused not only on the consequences of negative life events in this species, but also the protective role of relatively short periods of positive social activity on subsequent emotional development. © 2010 Wiley Periodicals, Inc
Neuro-Evolutionary Foundations of Infant Minds: From Psychoanalytic Visions of How Primal Emotions Guide Constructions of Human Minds toward Affective Neuroscientific Understanding of Emotions and Their Disorders
No full textAs Louis Sander understood, human infants are evolutionarily endowed with emotional minds that allow them to experience themselves as affectively vibrant creatures, who seek to be recognized as important players in the world. If so recognized, they experience themselves as positive individuals; if merely neglected as predetermined beings whose affects and intentions do not matter in the long-term construction of their minds, paths toward adult disturbance are paved. The neuroscience of affective processes has been substantively advancing through the use of animal models where the needed detailed experimental work can be conducted. Critical neural networks and neuro-epigenetic brain changes are being documented that provide neuroscientific confirmations for the insights advanced by Sander and his many colleagues. Here we show how the deeply intersubjective, flexible nature of the mother-infant relationship is firmly expressed in the underlying biology of the basic limbic emotional systems. Rather than being deterministic, hard-wired affective switches, these emotional systems (e.g., CARE, PLAY, PANIC, SEEKING, RAGE, FEAR, and LUST) are modulated by (and, in turn, modify) the developing relationship between mother and infant. Thus, the nature-nurture debate can be meaningfully reconceptualized as a bio-psycho-social interactive model, in which biology shapes relationships, which, in turn, shape and sometimes radically modify the biology
Octodon degus. A useful animal model for social-affective neuroscience research: Basic description of separation distress, social attachments and play
No full textA challenge for social-affective neuroscience programs is to identify simple and yet valid animal models for studying the expression of basic social emotions and their role during different developmental windows, from infancy to adulthood. For example, although laboratory rats are useful for studying juvenile social interactions, they are not ideal for studying infant attachment bonds. Here, we evaluate current understanding of the social behavior of Octodon degus, a diurnal precocial rodent, to elucidate the value of this species as a model for social-affective neuroscience research. After a synopsis of species-specific characteristics and brain susceptibility to changes of social environment, our behavioral findings on degu social proclivities are summarized. We then discuss why this pre-clinical model provides a valuable addition to the commonly available animal models for the study of human psychopathology. © 2011 Elsevier Ltd
Exposure to cocaine dynamically regulates the intrinsic membrane excitability of nucleus accumbens neurons
No full textDrug-induced malfunction of nucleus accumbens (NAc) neurons underlies a key pathophysiology of drug addiction. Drug-induced changes in intrinsic membrane excitability of NAc neurons are thought to be critical for producing behavioral alterations. Previous studies demonstrate that, after short-term (2 d) or long-term (21 d) withdrawal from noncontingent cocaine injection, the intrinsic membrane excitability of NAc shell (NAcSh) neurons is decreased, and decreased membrane excitability of NAcSh neurons increases the acute locomotor response to cocaine. However, animals exhibit distinct cellular and behavioral alterations at different stages of cocaine exposure, suggesting that the decreased membrane excitability of NAc neurons may not be a persistent change. Here, we demonstrate that the membrane excitability of NAcSh neurons is differentially regulated depending on whether cocaine is administered contingently or noncontingently. Specifically, the membrane excitability of NAcSh medium spiny neurons (MSNs) was decreased at 2 d after withdrawal from either 5 d intraperitoneal injections (15 mg/kg) or cocaine self-administration (SA). At 21 d of withdrawal, the membrane excitability of NAcSh MSNs, which remained low in intraperitoneally pretreated rats, returned to a normal level in SA-pretreated rats. Furthermore, after a reexposure to cocaine after long-term withdrawal, the membrane excitability of NAcSh MSNs instantly returned to a normal level in intraperitoneally pretreated rats. Conversely, in SA-pretreated rats, the reexposure elevated the membrane excitability of NAcSh MSMs beyond the normal level. These results suggest that the dynamic alterations in membrane excitability of NAcSh MSNs, together with the dynamic changes in synaptic input, contribute differentially to the behavioral consequences of contingent and noncontingent cocaine administration
Evolutionary aspects of self- and world consciousness in vertebrates
Full text linkAlthough most aspects of world and self-consciousness are inherently subjective, neuroscience studies in humans and non-human animals provide correlational and causative indices of specific links between brain activity and representation of the self and the world. In this article we review neuroanatomic, neurophysiological and neuropsychological data supporting the hypothesis that different levels of self and world representation in vertebrates rely upon (i) a “basal” subcortical system that includes brainstem, hypothalamus and central thalamic nuclei and that may underpin the primary (or anoetic) consciousness likely present in all vertebrates; and (ii) a forebrain system that include the medial and lateral structures of the cerebral hemispheres and may sustain the most sophisticated forms of consciousness [e.g., noetic (knowledge based) and autonoetic, reflective knowledge]. We posit a mutual, bidirectional functional influence between these two major brain circuits. We conclude that basic aspects of consciousness like primary self and core self (based on anoetic and noetic consciousness) are present in many species of vertebrates and that, even self-consciousness (autonoetic consciousness) does not seem to be a prerogative of humans and of some non-human primates but may, to a certain extent, be present in some other mammals and bird
Exposure to Cocaine Alters Dynorphin-Mediated Regulation of Excitatory Synaptic Transmission in Nucleus Accumbens Neurons
No full textDysregulation of excitatory synaptic input to nucleus accumbens (NAc) medium spiny neurons (MSNs) underlies a key pathophysiology of drug addiction and addiction-associated emotional and motivational alterations. Dynorphin peptides, which exhibit higher affinity to κ type opioid receptors, are upregulated within the NAc upon exposure to cocaine administration, and the increased dynorphin-signaling in the NAc has been critically implicated in negative mood observed in cocaine- or stress-exposed animals. Despite such apparent behavioral significance of the NAc dynorphins, the understanding of how dynorphins regulate excitatory synaptic transmission in the NAc remains incomplete
An analysis of affective ultrasonic vocalizations of rats as a function of social play and tickling
Full text linkHonors College, Washington State UniversityFyrqvist, Kate An analysis of affective ultrasonic vocalizations of rats as a function of social play and tickling, Washington State University Honors College thesis, Spring 2013, 34 p
Empathy in children: theory and assessment
No full textEmpathy is the ability to perceive, share, and understand the emotional states of others, and it is crucial to succeeding in society. This social and emotional competence underlies some of the most significant human interactions from the first bonds between mother and child all the way to more complex forms of prosocial behavior (Batson, 2009), all of which may even be essential for survival. Empathy is critical to social bonds, especially mother and child (Plutchik, 1987). The field of child mental health is especially focused on emotional development (Shore, 2001). Therefore, the neuropsychological understanding of attachment and empathy may create a more accurate and comprehensive model of the normal development of the human body, brain, and mind in the early stages of development and, consequently, lead to more accurate definitions of the adaptive basis for mental health of children (Shore, 2001). Most models of empathy emphasize that helping behavior is motivated by emotional states activated by the emotional states of others, a capacity which develops in the context of parental care and other social bonds (Hrdy, 2009). The resulting sense of security that leads children to adopt a more empathic attitude not only in intimate relationships but also toward others with whom they do not have such close relationships. Despite the importance of empathy as a basic socioemotional development process, it has been difficult to develop a theory that integrates its emotional and cognitive aspects as well as to create adequate operational definitions in order to test theories more empirically. This challenge is especially evident when trying to assess empathy in children through self-reports that provide a multidimensional measurement.This chapter will discuss the different theoretical perspectives of empathy and its manifestation in children, and will introduce a multidimensional empathy questionnaire developed for children between 9 and 12 years of age, that is based on models proposed by social cognitive neuroscience. This questionnaire integrates four aspects of empathy: a) emotional contagion, which is an affective reaction to another person that typically involves sharing the emotional state of that person; b) self-consciousness, which protects the boundary between self and other despite a transient identification with that person; c) perspective taking, which implies the cognitive ability to put oneself in the place of the other; and d) emotional self-regulation, which occurs through self-regulatory and control mechanisms that regulate and modulate personal emotional states.Fil: Richaud, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental Dr. Horacio J. A. Rimoldi; ArgentinaFil: Lemos, Viviana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental "Dr. Horacio J. A. Rimoldi". Grupo Vinculado CIIPME - Entre Ríos - Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental "Dr. Horacio J. A. Rimoldi"; ArgentinaFil: Oros, Laura Beatriz. Universidad de la Cuenca del Plata. Secretaría de Políticas del Conocimiento. Instituto de Investigaciones Científicas (Sede Posadas); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental Dr. Horacio J. A. Rimoldi; Argentin
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