16,256 research outputs found
Prognostic impact of pancreatic intraepithelial neoplasia (PanIN)-III accompanying chronic pancreatitis in patients who underwent R0 resection for pancreatic adenocarcinoma.
No full text 246 Background: The clinical significance of pancreatic intraepithelial neoplasia (PanIN)-III, known as carcinoma in situ of pancreatic ductal adenocarcinoma (PDAC), remains unclear yet. Recent research showed inflammation enhanced early cellular invasion of PanIN-III by facilitating epithelial to mesenchymal transition (EMT), even before frank malignancy in experimental model. Therefore we decided to investigate whether PanIN-III accompanying chronic pancreatitis (CP) might have an important prognostic impact in patient who underwent curative resection for PDAC. Methods: Medical records of 199 PDAC patients with R0 resection were reviewed. Presence and grade of PanIN and CP in resected specimen were determined based on College of American Pathologists protocol. Overall survival (OS) and disease free survival (DFS) were analyzed according to PanIN-III and CP. Results: CP was observed in 19.6% (39/199) of resected specimen and PanIN-III in 21.1% (42/199). In the group with CP, PanIN-III was associated with poor prognosis in univariate analysis (16.6 months vs. 32.0 months, P=0.001 for OS and 7.5 months vs. 15.1 months, p=0.012 for DFS), whereas PanIN-III was not a prognostic factor in the group without CP. When we divided into two groups [PanIN-III accompanying CP (n=12) vs. the others (n=187)], it showed that median DFS and OS were significantly shorter in PanIN-III and CP group than those of the others (7.5 months and 16.6 months vs. 12.4 months and 26.0 months, p=0.017 and p=0.003, respectively). In multivariate analysis, PanIN-III accompanying CP remained a statistically significant poor prognostic factor (HR: 2.06; 95% CI: 1.008 to 4.221; p=0.048 for OS, HR: 2.6; 95% CI: 1.267 to 5.462; P=0.009 for DFS using Cox proportional hazard ratio). Conclusions: PanIN-III accompanying CP might influence on poor long-term outcomes in patients who underwent R0 resection for PDAC. Therefore, it would support that chronic inflammation could enhance the dissemination of carcinoma in situ. </jats:p
Primary cilia (PC) in pancreatic intra-epithelial neoplasia (PanIN) and pancreatic cancer cells (PDAC).
No full text(A) Comparison between PanIN 1a (*) and PanIN 1B (#), the latter showing papillary epithelium and reduced number of cilia. (B) PanIN 3 lesion. Epithelial cells do not carry cilia while PC are present in stromal cells (*). (C) Loss of epithelial PC in PDAC (indicated by arrows), while in the stromal cells there is a noticeable increase of both the length of PC and the number of PC carrying cells (*). (D) Length of epithelial PC is decreased in PanIN lesions in comparison to normal pancreas (donor). (E) Gradual loss of epithelial PC in PanIN lesions. In PDAC, almost no epithelial PC were detected. (F) In stromal tissue around PanIN lesions and PDAC (G1/G2), an increased length of PC and (G) increased fraction of cilia carrying cells was evident compared to normal pancreas (donor). Kruskal-Wallis test: p p p p p p p p < 0. 05 vs PanIN 1B, acetylated α-tubuline: red, γ-tubuline: green, DAPI: blue. Mean ± SEM.</p
Expression of SNAIL in accompanying PanIN is a key prognostic indicator in pancreatic ductal adenocarcinomas
No full textAbstract Pancreatic ductal adenocarcinoma (PDAC) is the most lethal cancer, mainly because of its invasive and metastatic characteristics. Pancreatic intraepithelial neoplasia (PanIN) is one of the major precursor lesions of PDAC. Although epithelial‐to‐mesenchymal transition (EMT) is known to play an important role for these malignant behaviors, the association between PanIN and EMT has not been clearly understood. Therefore, we explored possible molecules for regulation of EMT immunohistochemically. Using surgically resected specimens from 71 PDAC patients, expressions of SNAIL, SLUG, TWIST1, and ZEB1 were investigated in high‐grade PanIN (HG‐PanIN) and PDAC. Results demonstrated that PDAC accompanied by SNAIL‐positive HG‐PanIN showed a significantly better relapse‐free survival (RFS) (median survival time (MST) of 11.3 months vs 4.4 months, P < 0.001) and overall survival overall survival (OS) (MST of 25.2 months vs 13.6 months, P < 0.001). In PDAC accompanied by SLUG‐positive HG‐PanIN, RFS and OS (P = 0.09 and P = 0.05) tended to have a better prognosis. In contrast, we could not find any significant prognostic benefits in the expression of TWIST1 or ZEB1 in PDAC accompanied by HG‐PanIN. Our present results suggest that (1) EMT may play an important role in the development of PDAC from HG‐PanIN, and (2) SNAIL may predict a distinct subgroup that shows a better prognosis
Outcomes in intraductal papillary mucinous neoplasm-derived pancreatic cancer differ from PanIN-derived pancreatic cancer
No full textBackground and Aim: Intraductal papillary mucinous neoplasm (IPMN)-derived pancreatic ductal adenocarcinoma (PDAC) management is generally extrapolated from pancreatic intraepithelial neoplasia (PanIN)-derived PDAC guidelines. However, these are biologically divergent, and heterogeneity further exists between tubular and colloid subtypes. Methods: Consecutive upfront surgery patients with PanIN-derived and IPMN-derived PDAC were retrospectively identified from international centers (2000–2019). One-to-one propensity score matching for clinicopathologic factors generated three cohorts: IPMN-derived versus PanIN-derived PDAC, tubular IPMN-derived versus PanIN-derived PDAC, and tubular versus colloid IPMN-derived PDAC. Overall survival (OS) was compared using Kaplan–Meier and log-rank tests. Multivariable Cox regression determined corresponding hazard ratios (HR) and 95% confidence intervals (95% CI). Results: The median OS (mOS) in 2350 PanIN-derived and 700 IPMN-derived PDAC patients was 23.0 and 43.1 months (P < 0.001), respectively. PanIN-derived PDAC had worse T-stage, CA19-9, grade, and nodal status. Tubular subtype had worse T-stage, CA19-9, grade, nodal status, and R1 margins, with a mOS of 33.7 versus 94.1 months (P < 0.001) in colloid. Matched (n = 495), PanIN-derived and IPMN-derived PDAC had mOSs of 30.6 and 42.8 months (P < 0.001), respectively. In matched (n = 341) PanIN-derived and tubular IPMN-derived PDAC, mOS remained poorer (27.7 vs 37.4, P < 0.001). Matched tubular and colloid cancers (n = 112) had similar OS (P = 0.55). On multivariable Cox regression, PanIN-derived PDAC was associated with worse OS than IPMN-derived (HR: 1.66, 95% CI: 1.44–1.90) and tubular IPMN-derived (HR: 1.53, 95% CI: 1.32–1.77) PDAC. Colloid and tubular subtype was not associated with OS (P = 0.16). Conclusions: PanIN-derived PDAC has worse survival than IPMN-derived PDAC supporting distinct outcomes. Although more indolent, colloid IPMN-derived PDAC has similar survival to tubular after risk adjustment
AFM study of the oxide film formed on dual phase Fe3Al-Fe3AlC intermetallies
No full textThe topography of the oxide film formed during initial stage of oxidation at 800 degreesC on the Fe3Al and Fe3AlC phases in an Fe- 16Al-0.5C alloy was analyzed using atomic force microscopy. The oxide film formed on the carbide phase was found to be thicker than that on the matrix, and the difference in thickness between two layers was around 0.5 mum. This was related to the presence of low Al content in the Fe3AlC phase compared with that in the Fe3Al phase. Due to different rate of oxidation in Fe3Al and Fe3AlC phases, the Fe- 16Al-0.5C alloy does not follow the parabolic rate behaviour. (C) 2004 Elsevier Ltd. All rights reserved.The author VSR thanks Prof. V.S. Raja of corrosion
science and engineering program, Indian Institute of
Technology, Bombay and Dr R.G. Baligidad of Defense
Metallurgical Research Laboratory, Hyderabad, India for
providing the material
Open access self-archiving: An author study
No full textThis, our second author international, cross-disciplinary study on open access had 1296 respondents. Its focus was on self-archiving. Almost half (49%) of the respondent population have self-archived at least one article during the last three years. Use of institutional repositories for this purpose has doubled and usage has increased by almost 60% for subject-based repositories. Self-archiving activity is greatest amongst those who publish the largest number of papers. There is still a substantial proportion of authors unaware of the possibility of providing open access to their work by self-archiving. Of the authors who have not yet self-archived any articles, 71% remain unaware of the option. With 49% of the author population having self-archived in some way, this means that 36% of the total author population (71% of the remaining 51%), has not yet been appraised of this way of providing open access. Authors have frequently expressed reluctance to self-archive because of the perceived time required and possible technical difficulties in carrying out this activity, yet findings here show that only 20% of authors found some degree of difficulty with the first act of depositing an article in a repository, and that this dropped to 9% for subsequent deposits. Another author worry is about infringing agreed copyright agreements with publishers, yet only 10% of authors currently know of the SHERPA/RoMEO list of publisher permissions policies with respect to self-archiving, where clear guidance as to what a publisher permits is provided. Where it is not known if permission is required, however, authors are not seeking it and are self-archiving without it. Communicating their results to peers remains the primary reason for scholars publishing their work; in other words,
researchers publish to have an impact on their field. The vast majority of authors (81%) would willingly comply with a mandate from their employer or research funder to deposit copies of their articles in an institutional or subject-based repository. A further 13% would comply reluctantly; 5% would not comply with such a mandate
The incidence of pancreas pathology of male and female mice.
No full textA) The incidence of pancreatic precursor lesions (PanIN-1, PanIN-2, PanIN-3) and PDAC in all the KC mice match what was previously reported in this model. B) There is no statistically significant differences in development of pancreatic pathology between male (n = 16) and female KC (n = 14) mice. Both males and females show a 100% incidence of PanIN-1 (p-value = 1). PanIN-1, PanIN-2, PanIN-3 and PDAC male vs female incidence with their p-vales are as follows: 100% vs 100% (p = 1), 6.25% vs 7.15% (P > 0.99), 0% vs 21.43% (P = 0.09) and 6.25% vs 28.57% (P = 0.16). (TIF)</p
Average per-author h-index vs Average REF Impact Score.
No full textAverage per-author h-index vs Average REF Impact Score.</p
Telomere length in normal duct epithelium from autopsy cases.
No full text<p>(a) NTCR in the normal duct epithelium in 150 autopsy cases was negatively correlated with age for the cases overall (n = 150, black), the control group (n = 77, blue) and the PanIN group (n = 73, green). (b) Comparison of NTCR in the normal duct epithelium between the control and PanIN groups. **<i>P<0</i>.<i>01</i> vs control. (c) NTCR in normal duct epithelium from individuals aged over 50 years (n = 113). Blue, control (n = 43); green, PanIN group (n = 70). (d) Comparison of NTCR in the normal duct epithelium between the control and PanIN groups. *<i>P<0</i>.<i>05</i> vs control.</p
Proportion of junior vs. senior authors positioned first in the author byline of POA publications.
No full textProportion of junior vs. senior authors positioned first in the author byline of POA publications.</p
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