13 research outputs found
Comparative Evaluation of Robinson’s Cytological Grading with Elston and Ellis’ Nottingham Modification of Bloom Richardson Histopathology Grading for Breast Carcinoma
No full textBackground: Cytological grading of mammary carcinoma provides useful information about prognosis. It also helps in selecting therapy. Aim: This study has been carried out to compare correlation of Robinson’s cytological grading with modified Bloom Richardson grading system of infiltrating ductal carcinoma in histology.
Material and method: 59 FNAC smears of, invasive breast carcinoma, were graded according to the Robinson’s grading system. Corresponding histology sections were graded according to Elston and Ellis’ Nottingham modification of Bloom Richardson method.
Result: On cytology, there were 24, 26 and 9 cases of grade I, II and III tumor respectively while on histology 25, 24 and 10 cases of grade I, II and III tumor respectively. The concordance rate between cytology and histology grades were 79.16%, 73.07% and 66.66% for grade I, II and III tumor respectively. Absolute concordance rate was 74.57%.
Conclusion: Apart from being simple and non-invasive, cytologic grading method is comparable with histologic grading system. It might provide information about aggressiveness of tumor and is useful parameter while selecting neo adjuvant chemotherapy in patients of breast carcinoma
A Case of Malignant Low Grade Endometrial Stromal Sarcoma and Review of The Literature
No full textLow grade endometrial stromal sarcoma is a rare pelvic malignancy that arises from the endometrium. This article describes the morphological features of one such tumour discovered as finding in a hysterectomy specimen of a 32-year lady with a clinical diagnosis of dysfunctional uterine bleeding with multiple fibroids. Morphological and immunohistochemical evaluations were performed and a final diagnosis of low grade endometrial stromal sarcoma was given. This report is aimed to present a case of endometrial stromal tumor because of its rare existence and difficulties in establishing histological diagnosis
A Case of Invasive Micro Papillary Carcinoma of The Breast with Literature Review
No full textInvasive micro papillary carcinoma has been recognized as rare but distinctive variant of carcinoma in various anatomic sites, including breast, urinary bladder, lung and major salivary glands. The tumor is characterized by nested pattern of eosinophilic tumor cells arranged in a solid, morular, tubular patterns. Most often this growth pattern is mixed with conventional carcinoma or other variants. Patients have typically high-stage disease at presentation and a poor clinical outcome compared with that of patients with conventional carcinoma arising in the same organ site.
We report a case of 65-year-old woman with painful lump in right breast, admitted to the surgical ward of our institute, diagnosed as invasive micro papillary carcinoma of the breast histopathologicaly and immunohistochemically
Cervical Pap Smear Study and Its Utility in Cancer Screening, To Specify the Strategy for Cervical Cancer Control
No full textThe study was conducted to explore various lesions of Uterine cervix [inflammatory and growth], to find out target age group in which screening efforts can be concentrated for early detection as well as reduction of the incidence of cervical cancer, in our set up. Patients in the age group 15-50 and 50-78 years with various complaints were screened during June 2006 to December 2007. Total 995 patients were studied. Slides were fixed in 95% ethyl alcohol and stained with Pap stain. Slides were reported according to the 2001 Bethesda System, by cytopathologists. Out of 995 patients studied, 940 showed inflammation and other benign lesions. 55 patients showed premalignant and malignant lesions. Premalignant lesions were present in 30-50 year of age group
Para-Bombay phenotype: A case report from a tertiary care hospital from South Gujarat
No full textThe blood specimen of a 30-year-old male donor showing a discrepancy in cell and serum grouping was targeted for detailed study at the blood bank at tertiary care hospital in South Gujarat. Forward grouping showed group as “O” RhD positive and reverse grouping as group “A.” Further testing confirmed that the individual's blood group was para-Bombay A (para-AH). Family members were screened, and younger brother was also identified as para-Bombay phenotype. The para-Bombay phenotype is very rare, and only a few cases have been reported from India. This blood group is characterized by the absence of ABH antigens on red blood cells (RBC's) with the presence of ABH substances in body secretions or by the weak expression of ABH antigens on RBC's with the absence or presence of substances in body secretions. This rare phenotype can be mislabeled as “O” if all detailed investigations are not performed
THE STUDY OF PLATELET VOLUME INDICES IN PLATELET APHAERESIS PROCEDURE: AN EXPERIENCE OF 271 PLATELET APHAERESIS PROCEDURES
No full textBackground: Platelet activity can be assessed by platelet volume indices like MPV, PDW & P-LCR.
Aim: To develop an approach in blood bank professional, a habit of looking at platelet indices in hematology analyzer report of aphaeresis donors & QC samples of platelet aphaeresis products.
Methods and materials: A retrospective data analysis was done for 271 platelet aphaeresis procedures conducted on CS3000 plus with AMS cell separator, Fenwal, USA& COM.TEC, Fresenius Kabi, Germany. Samples of the donors were collected before aphaeresis & 1 to 2 ml sample from each bag was collected in the satellite pouch attached to bag & analysis was done on day 0 & day 7. Platelet parameters were measured on automated hematology analyzers SYSMEX KX-21 & Horiba Micros 60.Statistical analysis: Statistical analysis was done by calculating ‘r value’ & a paired t test at 95 % confidence interval. A P value of <0.05 was taken as significant.
Results: The mean platelet yield was 3.39±0.88 x 1011/unit. The platelet yield correlated negatively with MPV, PDW and PLCR (r value -0.224, -0.045 & -0.159 respectively for correlation between MPV, PDW & PLCR with the yield, P <0.0001).The mean values of PVI of SDP were significantly smaller than that of donor pre-donation samples (paired t test P value < 0.05).The size of stored single donor platelet on day 7 were significantly larger than that of day 0 (P value < 0.05).
Conclusion: The platelet indices are useful to study - selectively smaller platelet separation by automated cell separators, storage lesions & yield prediction
Frequency and distribution of ABO and Rh blood groups among blood donors in tertiary care hospital of South Gujarat, India
No full textBackground: Since it was discovered by Karl Landsteiner, the ABO blood group system is the most important blood group system in Transfusion Medicine. The blood group systems are also very important in population genetic studies, researching population migration patterns as well as resolving certain medico-legal issues, particularly disputed parentage. This study was carried out with an objective to provide data regarding gene frequency and distribution of ABO and Rh blood groups among blood donors in South Gujarat, India.Methods: Data of 40732 blood donors were retrospectively collected and analyzed regarding ABO and Rh blood groups from May-2011 to April-2016 and reported in simple numbers and percentage. Blood group of the blood donors was determined by forward and reverse methods with the help of commercially available standard monoclonal antisera by test tube and column agglutination techniques in required cases.Results: The most common blood group among donors was B (34.43%) followed by O (32.26%), A (24.35%), while the least prevalent blood group was AB (8.94%). Rh positivity among donors was (95.12%). Rests were Rh Negative (4.87%). The estimated gene frequencies were 0.1844 for IA (p), 0.2477 for IB (q) and 0.5679 for IO (r).Conclusions: The most common blood group in donors was B positive and least common was AB negative
Transfusion effect of random donor platelet and single donor platelet in thrombocytopenic patients at tertiary care hospital of South Gujarat
No full textBackground: Platelet transfusion plays a key role in therapy for the patients with thrombocytopenia. Superiority of Single donor platelet (SDP) over Random donor platelet (RDP) transfusions is largely assumed, but unproven. Platelet Rich Plasma-Platelet concentrate (PRP-PC) and Apheresis-PC were prepared and their therapeutic efficacy were assessed in thrombocytopenic patients.Methods: This study included 60 transfusion episodes consisting of 30 SDP and 30 RDP (147units of RDP). The post transfusion efficacy of transfused platelets was assessed at 1 hour and 24 hours by corrected count increment (CCI) and percentage recovery (PR). Paired ‘t’-test was used for statistical analysis and a probability of p<0.05 was used to reject null hypothesis.Results: The mean platelet dose of SDP (n=30) and RDP (n=30) was 2.86±1.05 x 1011 and 2.36±0.54 x 1011 respectively. The mean platelet increments of SDP at 1 hour and 24 hours were 38±18.1 x 103/μl and 37.3±20.7x 103/μl. The mean platelet increments of RDP at 1 hour and 24 hours were 28.5±11.4 x 103/μl and 26 ±11.6 x 103/μl. The mean CCI of SDP at 1hour and 24 hours were 21.4 ±7.3 x 103/μl and 20.8±7.4 x 103/μl respectively. The mean CCI of RDP at 1hour and 24 hours were 18.5±6.3x 103/μl and 17.4±7.6 x 103/μl respectively.Conclusions: Post-transfusion increments were significantly higher in patients who received SDP as compared to RDP, but the CCI and PR were comparable in both groups of patients.</jats:p
