851 research outputs found
Altered excitation-contraction coupling in human chronic atrial fibrillation
No full textThis review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory period, depressed intracellular Ca<sup>2+</sup> transient, and reduced myocyte contractility. Here we summarize the current knowledge of the ionic bases underlying these changes. Understanding the molecular mechanisms of excitation-contraction-coupling remodeling in the fibrillating human atria is important to identify new potential targets for AF therapy
Turbulent plane Couette flow with wall-transpiration
No full textIn the present abstract, DNS results obtained for turbulent plane Couette flow with wall-normal transpiration velocity are presented. Important equations valid in such a flow are derived, describing the total shear stress and the relation between the friction velocities at the lower and upper wall. These expressions are of importance, as there are neither experimental nor DNS data to compare with. Equally important, we derive a center region and a viscous sublayer velocity scaling for the suction wall, which were both validated using the DNS data
Correction to " Saint-Santin Radar Observations of Lower Thermospheric Storms"
No full textInternational audienceIn the paper "Saint-Santin Radar Observations of Lower Thermospheric Storms" by C. Mazaudier, R. Bernard and S.V. Venkateswaran (Journal of Geophysical Research 90 (A3), 2885-2895) the name of the third author was inadvertently omitted from the first page. A corrected first page follow
Pharmacotherapy for POAG. Individual approach
No full text
S.V. Balalin, V.P. Fokin
S. Fyodorov Eye Microsurgery Federal State Institution, Volgograd branch, Volgograd, Russian Federation
Glaucoma is still one of the leading causes of the blindness and low vision. According to the World Health Organization, an estimated number of glaucoma patients is 60.5 to 105 million and is growing steadily. In many highly developed countries, glaucoma accounts for 13–28% of blindness. High intraocular pressure (IOP) is the most important risk factor for glaucomatous optic neuropathy and low vision in primary open-angle glaucoma (POAG). It was demonstrated that IOP lowering to the individual tolerant level in POAG preserves vision for a long time.
The paper discusses potential adoption of of the software for the calculation of tolerant IOP in POAG. Tolerant IOP calculations will help to adjust treatment in time to achieve individual IOP normal ranges, to predict glaucoma stabilization or progression as well glaucoma progression rate. The algorithm of treatment strategy for POAG is described.
Key words: glaucoma, primary open-angle glaucoma, intraocular pressure, tolerant IOP, glaucomatous optic neuropathy, prostaglandin analogue, latanoprost, Trilactan.
For citation: Balalin S.V., Fokin V.P. Pharmacotherapy for POAG. Individual approach. Russian Journal of Clinical Ophthalmology. 2019;19(1):43–48.
About the authors:
Sergey V. Balalin — MD, PhD, Head of the Scientific Department of the Volgograd branch;
Viktor P. Fokin—MD, PhD, Professor, Director of the Volgograd branch.
S. Fyodorov Eye Microsurgery Federal State Institution, Volgograd branch. 80, Zemlyachki str., Volgograd, 400138, Russian Federation. Contact information: Sergey V. Balalin, e-mail: [email protected]. Financial Disclosure: no author has a financial or property interest in any material or method mentioned. There is no conflict of interests. Received 23.10.2018.<br
Analysis of Design Parameters of Highway Subgrade Soils in Southern Russia
No full textAbstractThe paper describes a methodology for analyzing the design humidity of subgrade soils under dry-land conditions in Southern Russia. The author has studied the strength characteristics of subgrade soils depending on their humidity and densit
Optimized Data Aggregation Method for Time, Privacy and Effort Reduction in Wireless Sensor Network
No full textWireless sensor networks (WSNs) have gained wide application in recent years, such as in intelligent transportation system, medical care, disaster rescue, structure health monitoring and so on. In these applications, since WSNs are multi-hop networks, and the sink nodes of WSNs require to gather every sensor node’s data, data aggregation is emerging as a critical function for WSNs. Reducing the latency of data aggregation attracts much research because many applications are event urgent. Data aggregation is ubiquitous in wireless sensor networks (WSNs). Much work investigates how to reduce the data aggregation latency. This paper considers the data aggregation method based on optimization of required time, maintain privacy while keeping lesser efforts by data aggregation in a wireless sensor network (WSN) and propose a method for the solution of the problem
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