23 research outputs found
Repair of oxidative damage in DNA induced by photoactivated methylene blue in human lymphoblastoid whole cell extracts
No full textOxidative damage on DNA is an incessant, inevitable result of cellular metabolic activity as well as environmental carcinogens. Oxidative damage produces many different lesions. A highly specific substrate containing mainly 8-hydroxyguanine lesion was generated and an in vitro DNA repair synthesis assay was developed using human lymphoblastoid whole cell extracts. Photoactivated methylene blue introduced 1.58 Formamidopyrimidine glycosylase sensitive sites into the plasmid. The damage specific repair incorporation of deoxycytidine monophosphate by normal whole cell extracts was 10 times more efficient per 8-Hydroxyguanine than per (6-4) photoproduct. The rapid rate of nicking by normal whole cell extracts implies that the lesion is recognized efficiently and that damage specific nicking was not the rate limiting step in the repair of 8-Hydroxyguanine. Based on the difference in rate and amount of nucleotide specific incorporation, more than one pathway was indicated for repair of this oxidative lesion. A model, proposing single base replacement and small patch (6 nucleotides) size repair was designed. The fraction of nucleotides processed by normal cell extracts through single base replacement is 0.38 and the fraction of nucleotides processed through the small patch repair was 0.62. Repair of 8-Hydroxyguanine by normal whole cell extracts occurred predominantly through small patch repair.Source: Dissertation Abstracts International, Volume: 58-09, Section: B, page: 4616.Advisors: S. J. Mazur.Ph.D. American University 1997.Englis
Humour in Indian writing in English: three novels women writers : Namita Gokhale's Paro dreams of passion, Suniti Namjoshi's The conversations of cow, Arundhati Roy's The god of small things
No full textThe key words in the title of the thesis are problematic and need to be defined at the outset. Humour, which is ordinarily conflated with comedy, satire, irony and its various other forms, presents problems of terminology. The adjectives 'Indian' and 'women' used to qualify the writers, also present some difficulties. Before launching into a discussion of humour and the artistic modes and genres one associates with it, it is important to address the question of the credentials of 'Indianness' of the three writers. Gokhale (b. 1956) author of Paro Dreams of Passion, started out as a journalist who still lives and works in India. Roy (b. 1961) the Booker prize-winning author of The God of Small Things, is touted as a 'home-grown' who has neither studied nor lived abroad. Namjoshi (b. 1941) has lived abroad, and taught English literature in Canada and now works in the U.K. However, her themes and inspirations are as 'Indian' as those of Anita Desai, Ruth Prawer Jhabvala or Shashi Deshpande. She belongs within the category of diasporic Indian writers and attributes some of her textual tactics to India. Namjoshi wrote 'The Conversations of Cow' in Canada and is included in books of literary criticism (Naik & Narayan, 2001) as a diasporic writer of Indian origin
School of Music and Arts, Gwalior
No full text"If architecture is frozen music then music must be liquid architecture." - Quincy Jones
Music, Art and Culture have always been an integral part in growth of the Gwalior city, the Gwalior Gharana being the oldest Khyal Gharana. The favourite singer at the court of Mughal Emperor Akbar, Miyan Tansen was from the town. Gwalior has produced some extra-ordinary and famous artists like Ustad Amjad Ali Khan, Ustad Ghulam Hassan Shaggan, Meeta Pandit, Neela Bhagwat and many more. Ironically, Indian Classical music is gaining popularity world wide but gradually losing its base in the Indian subcontinent, from where it has originated.
So, School for Music and Arts, particularly responding to Indian Classical style of music has been proposed in the city to conserve this art form. The composition of a musical piece and the structure of a building follow the same design principles. Hence, the design challenge was to incorporate musical terms such as rhythm, texture, harmony, proportion, dynamics, and articulation which refer both to architecture and to music in the design.
I strongly believe that no design is original and is influenced from nature.I have taken such influences too from my surrounding
A comparative study to determine the effectiveness of oral mifepristone and vaginal isosorbide mononitrate as cervical ripening agents for induction of labor in pregnant women with gestational age 28 to 34 weeks
No full textBackground: The process of inducing labor is definitely one of the most commonly done obstetric procedures worldwide. An unfavourable cervix is a major reason for unsuccessful induction. Cervix must be softened. IOL should only be performed when there is an obvious medical need and advantages are greater than risks.
Methods: The present study was conducted at the Department of Obstetrics and Gynaecology, MGM Medical College, Indore from February 2023 to January 2024.One hundred pregnant women of gestational age 28 to 34 weeks, who had a valid indication for termination of pregnancy, were included in the study after valid consent and randomised into two groups. Oral Mifepristone was used in one group and vaginal isosorbide mononitrate IMN in the other. Modified Bishops Score was subsequently assessed and compared.
Results: In the study, indications for termination were hypertensive disorders of pregnancy, IUFD, anhydramnios, severe oligohydramnios and PPROM. Mean±SD of Bishop score before and after IMN were 1.84±1.23 and 4.40±1.34, whereas for Mifepristone 1.42±1.42 and 4.92±1.68, respectively. Mean cervical ripening to delivery time in IMN group was 30.04±3.37 hours; while in mifepristone group, it was 28.50±3.48 hours. Most patients delivered vaginally in both the groups (IMN group 88%; mifepristone group 94%). Both Mifepristone and IMN were generally well-tolerated by participants.
Conclusions: This study provides evidence supporting the effectiveness of both drugs as cervical ripening agents
A prospective cohort study to determine effectiveness of cystoinflation to prevent bladder injury in women with previous caesarean section
No full textBackground: The rising rate of caesarean sections (C-sections) has led to an increase in associated surgical complications, particularly urinary bladder injuries in patients with dense pelvic adhesions. Repeat C-sections elevate the risk of such injuries due to adhesions between the bladder and uterus. Cystoinflation, or retrograde bladder filling with saline, has been proposed to improve visualization and reduce injury risk, but its application in C-sections is underexplored. The present study aimed to evaluate the effectiveness of intraoperative cystoinflation in reducing urinary bladder injury during C-sections in women with previous caesarean deliveries and dense pelvic adhesions.
Methods: This prospective cohort study was conducted at MGM medical college and MTH hospital, Indore, over 12 months (October 2022-October 2023). A total of 240 women undergoing C-sections with dense adhesions were divided into two groups: group 1 (n=120) with cystoinflation, and group 2 (n=120) without. Primary outcome was bladder injury; secondary outcomes included blood loss; duration of surgery, complications, and hospital stay.
Results: Bladder injuries occurred in 3.3% of patients in group 2 and none in group 1 (p<0.001). Urinary tract infections and micturition issues were also significantly lower in the cystoinflation group. Mean hospital stay was shorter in group 1 (4.10±0.42 days) than in group 2 (4.88±1.86 days, p<0.001). Blood loss and operative time showed non-significant trends favouring cystoinflation.
Conclusions: Cystoinflation is a safe, simple, and effective technique that significantly reduces bladder injury and postoperative complications during C-sections in high-risk women. Its routine use in such cases is recommended
Identity and textual engagement: experiences of three international students writing a doctoral thesis in EAL
No full textThe integration of the voices of other researchers is central to displaying scholarship in a doctoral thesis. It entails complex negotiation of prior texts in the context of one's own study. While, there is an expectation that such work results in an 'objective' tone, self-representation or identity is rarely absent in theses in most disciplines. For international students, who use English as an Additional Language (EAL), being objective and yet projecting an identity and a voice can pose considerable challenges. The present study draws on findings from a qualitative inquiry that has involved interviews with three international students and analysis of excerpts from drafts of their doctoral writing to examine how identity is constructed in the act of textual engagement. The term 'textual engagement' embraces acts such as integration of quotations in texts using conventions of citations and the evaluation of the quoted text/s as evident in the drafts. In the present thesis 'identity' has been discussed using Ivanič's (1998) concept of self-representation. Ivanič‘s (1998) construct of a writer's identity in terms of the autobiographical self, possibilities of selfhood, the discoursal self and the self as author dimensions in academic writing has been applied as the overarching theoretical framework in the present study. The thesis explores issues faced by international EAL students as they negotiate other texts and simultaneously project an identity of their own. It particularly focuses on how EAL writers position themselves in relation to other texts to construct a discoursal self and how they negotiate with other texts, consciously or unconsciously, to project the self as author dimension in their doctoral writing. The literature on the incorporation of prior studies in academic writing is rich in studies on plagiarism. However, many of these studies do not take into account the complexities that quoting from source texts involve, particularly for students writing in EAL. Other strands of the literature point out that using the voices of others‘ to negotiate space for one‘s own research or engaging with other texts to construct one‘s argument requires an understanding of the discursive practices of a discipline. Scholarship becomes the basis on which an original contribution to a discipline can be made. Displaying this scholarship can be challenging for many EAL doctoral writers who may have had limited exposure to reading in English prior to undertaking doctoral studies. Consequently, in incorporating other texts, they may struggle to present an appropriate voice in their writing. Drawing on the larger theory of intertextuality and the tools afforded by genre theory to analyse the construction of arguments, the present study seeks to understand these difficulties. The exploration of evaluation to deconstruct the self as author in the student writers‘ texts has involved the use of the APPRAISAL theory (Martin and White, 2005). The findings of the study suggests that in the writing of a thesis, a common possibility of selfhood is envisioned by the writers – that of being bilingual scholars and original contributors to the field. The autobiographical selves that the writers bring to the act of writing shape every aspect of the writing. In the context of the present study, where textual engagement and identity projection are investigated, interviews and the examination of the participants‘ texts suggested that the doctoral writers were not naïve about the demands of engaging with other texts in their work. However, the imperative to be objective and to take up a stance in relation to other texts was confusing. This issue in conjunction with anxieties about their competence in English is responsible for the varying degrees of self-assurance evident in the texts analysed in the study. The textual analysis suggests that textual transformation is seen as a major difficulty. However, positioning oneself in relation to the collective voices in the discipline is less so. Nevertheless, despite these infelicities in their work, the discoursal self projected is that of emerging scholars attempting to make an original contribution in their field. In all three texts, a non-adversarial stance is adopted. However, the self as author is different in each text and is related to the reading positions adopted by the individual writers. Surface irregularities in terms of grammar, syntax, semantics, inappropriate citation practices and the lack of critical analysis may diminish the quality of doctoral writing produced by EAL users. Nevertheless, the struggle to be bilingual scholars and original contributors is evident in the texts analysed. Pedagogical responses to difficulties in the area of textual engagement need to be addressed in the larger context of critical inquiry, knowledge construction, disciplinary practices and self-representation/identity discussions in texts. A triple-layered doctoral writing pedagogy is suggested. Harnessing linguistic theory and providing opportunities for social interaction and meaning negotiation is crucial in helping students develop rhetorical knowledge that would enable them to project a confident identity and facilitate competent textual engagement
Representation of Indian History in Rudyard Kipling’s Kim
No full textThe paper analyses how the writings of Rudyard Kipling mark the tidemark of literary reflection of the Indian culture. His writings conjure images of contemporary Anglo Indian setup. Rudyard Kipling has given a pen picture of the city of Lahore and Simla which had by 1882 started wearing the look of a colonial city. His novel Kim portrays an imperialist view of the colonial India. He reproduced in his personal life both the painful cultural changes that had taken place in his society and the history of British colonialism in India. Kipling\u27s writings seem to center mostly around India. kim actually show a real love and understanding for India. Here the author displays a vast knowledge of India, its culture, its many religious, and the lives of common folks especially the native poor. He tells good stories. Rudyard Kipling spent his early childhood with a Hindu bearer Meeta and a Goan Catholic ayah. He had spoken Hindustani before he spoke English. Though his stay in the India was short, yet it provided impetus to Rudyard Kipling to crystallize and consolidate his ideology of culture. It is elaborated with the help of his work Kim
Analysis of the implementation of integrated marketing communication in it companies on a selected example from the Croatian market
No full textU ovom radu obrađena je i analizirana tema integrirane marketinške komunikacije u
informatičko-tehnološkim poduzećima na odabranom primjeru s hrvatskog tržišta i to
u kontekstu provođenja analize i poboljšanja provođenja integrirane marketinške
komunikacije. U radu se objašnjavaju razlike između tradicionalnih i modernih
marketinških oblika te njihova upotreba u integriranoj marketinškoj komunikaciji. Cilj je
rada teorijski objasniti integriranu marketinšku komunikaciju, utvrditi koje alate i
tehnike integriranoga marketinškog komuniciranja koriste mala IT poduzeća.
Objašnjen je postupak provedbi komunikacijskih strategija u IT poduzećima za
provedbu integriranoga marketinškog komuniciranja.
IT poduzeća provode integrirano marketinško komuniciranje zato što ono na raznim
kanalima omogućuje prezentaciju poslovanja poduzeća, prilagođava poruke za razne
ciljane skupine, omogućuje poduzeću da se diferencira od konkurencije te omogućuje
praćenje i analizu rezultata kampanja na različitim kanalima i medijima što potiče
poboljšanje poslovanja. U radu je provedeno kvalitativno istraživanje u ožujku i travnju
2024. godine koje je obuhvaćalo dubinski polustrukturirani intervju i fokus grupu, a
moderatorica obaju istraživanja bila je autorica ovog rada. Dubinski polustrukturirani
intervju proveden je s marketinškom stručnjakinjom malog IT poduzeća u Hrvatskoj, a
fokus grupa provedena je virtualno putem Google Meeta u kojoj je sudjelovalo šest
komunikacijskih stručnjaka malih IT poduzeća. Istraživanje je objasnilo kako mala IT
poduzeća provode integrirano marketinško komuniciranje i da ga smatraju iznimno
važnim u svojem poslovanju zato što svojim sinergijskim učinkom i prenošenjem iste
poruke na raznim kanalima prenosi strukturiranu poruku. Kao najveći nedostatak
provođenja integriranoga marketinškog komuniciranja mala IT poduzeća navela su
nedovoljan broj radne snage što se nadovezuje na nedovoljno kapaciteta zaposlenika
za provođenje. Da bi integrirano marketinško komuniciranje bilo uspješno, ispitanici
navode da je najbitnije poznavati ciljanu skupinu zato što se na temelju toga bira medij
provođenja. Kao najuspješnije digitalne alate provođenja integriranoga marketinškog
komuniciranja navode e-mail marketing i društvene mreže.The topic of integrated marketing communications in IT companies is examined and
analyzed on a selected sample from the Croatian market, for the purpose of
conducting an analysis and improving the implementation of integrated marketing
communications. The research explains the differences between traditional and
modern marketing forms and their use in integrated marketing communication. The
aim of this paper is to theoretically explain integrated marketing communication, to
determine which tools and techniques of integrated marketing communication are
being used by small IT companies. Additionally, the procedure of implementing the
communication strategies in IT companies for the execution of integrated marketing
communication will be elaborated on the.
Furthermore, the reason why IT companies implement integrated marketing
communication is because it enables the presentation of the company's business
through various channels. Accordingly, it adjusts messages for various target groups,
enables the company to differentiate itself from the competition, and enables the
monitoring and analysis of campaign results on various channels and media which
propels business improvement. In this research, as a part of examination, a qualitative
research was done in March and April 2024, comprising an in-depth semi-structured
interview and a focus group, and the moderator of both researches was the author of
this paper. The in-depth semi-structured interview was conducted with a marketing
expert from a small IT company in Croatia, and six communication experts from small
IT companies in Croatia participated in the focus group virtually via Google Meet. The
qualitative research methods were use in order to obtain the in-depth insights into the
respondent’s opinion with the aim of providing for the best replies from the practice.
The research explained how small IT companies carry out the integrated marketing
communication and demonstrated that it is considered to be of great importance
because its synergistic effect and transmission of the same message through various
channels transmits a structured message. The small IT companies indicated labor
shortage as the most significant shortcoming in the implementation of integrated
marketing communication, which is the consequence of the lack of implementation
capacities of the employees. The respondents stated that, in order to make integrated
marketing communication a success, it is of great importance to be familiar with the
target group since this is the basis for the selection of the implementation media. They
indicated e-mail marketing and social networks as the most successful digital tools for
the implementation of integrated marketing communication
