175,319 research outputs found
Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7
No full textAdapter proteins containing Src homology 2 (SH2) domains link transmembrane receptor protein-tyrosine kinases to downstream signal transducing molecules. A family of SH2 containing adapter proteins including Grb7 and Grb10 has been recently identified. We had previously shown that Grb10 associates with Ret via its SH2 domain in an activation-dependent manner (Pandey, A., Duan, H., Di Fiore, P.P., and Dixit, V.M. (1995) J. Biol, Chem. 270, 21461-21463). We now demonstrate that the related adapter molecule Grb7 also associates with Ret in vitro and in vivo, and that the binding of the SH2 domain of Grb7 to Ret is direct. This binding is dependent upon Ret autophosphorylation since Grb7 is incapable of binding a kinase-defective mutant of Ret. Thus two members of the Grb family, Grb7 and Grb10, likely relay signals emanating from Ret to other, as yet, unidentified targets within the cell
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Theoretical study of nonpolar surfaces of aluminum nitride: Zinc blend (110) and wurtzite (10(1)over-bar-0)
No full textAll-electron density-functional calculations are performed to study atomic structure and electronic properties of the nonpolar surfaces, namely zinc blende (110) and wurtzite (10 (1) over bar 0) of AlN. Both surfaces are modeled using a two-dimensional periodic slab allowing the relaxation of the first two surface layers in the calculations. The results predict a small layer rotation angle accompanied by a contraction of Al-N bond length for both surfaces. These results do not follow the well-accepted rotation-relaxation model that predicts large layer rotation angles (similar to 28 degrees) with no change in the bond length for most of the III-V semiconductor surfaces. Analysis of the relaxed configurations of the AlN surfaces in terms of atomic geometry, density of states, and charge density plots shows a presence of partial double-bond character in the surface Al-N bond. A similarity of these results with an earlier study on GaN nonpolar surfaces [J. E. Jaffe, R. Pandey, and P. Zapol, Phys. Rev. B 53, R4209 (1996)] led us to suggest the contraction-relaxation model where the relaxation proceeds via strengthening of the surface bond. The primary driving force of such a type of relaxation appears to be the ability of nitrogen to form a double bond that facilitates redistribution of the charge density associated with anion dangling bond to the surface bond
Murder on the mountain: author talk with Peter J. Wosh
No full textAuthor talk by Peter J. Wosh on May 5th, 2022, on his book, "Murder on the Mountain: crime, passion, and punishment in gilded age New Jersey.
Mr. Melvin J. Collier, RWWL AUC, June 2011
No full textThis video is a conversation with Mr. Melvin J. Collier. Mr. Collier talks about his book, "From Mississippi to Africa: A Journey of Discovery". Daniel Le, AUC Woodruff Library, is the interviewer
Mechanistic insights into conformational changes that accompany the binding of negative allosteric modulators to the cannabinoid receptor 1
No full textGraduate students: AyoOluwa Aderibigbe, Department of BioMolecular Sciences, Division of Medicinal Chemistry; Pankaj Pandey, National Center for Natural Products ResearchMajor/Minor: Pharmaceutical SciencesFaculty advisor: Robert J. Doerksen, Department of BioMolecular Sciences, Division of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, School of Pharmacyhttps://egrove.olemiss.edu/neuro_showcase/1000/thumbnail.jp
Prosodic issues in synthesising thadou, a tibeto-burman tone language
No full textGibbon D, Pandey P, Haokip DMK, Bachan J. Prosodic issues in synthesising Thadou, a Tibeto-Burman tone language. In: Interspeech 2009. ISCA: ISCA; 2009: 500-503
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