324 research outputs found
Efficient Neural Network Architecture Search
No full textOne-Shot Neural Architecture Search (NAS) is a promising method to significantly reduce search time without any separate training. It can be treated as a Network Compression problem on the architecture parameters from an overparameterized network. However, there are two issues associated with most one-shot NAS methods. First, dependencies between a node and its predecessors and successors are often disregarded which result in improper treatment over zero operations. Second, architecture parameters pruning based on their magnitude is questionable. In this thesis, classic Bayesian learning approach is applied to alleviate these two issues. Unlike other NAS methods, we train the over-parameterized network for only one epoch before update network architecture. Impressively, this enabled us to find the optimal architecture in both proxy and proxyless tasks on CIFAR-10 within only 0.2 GPU days using a single GPU. As a byproduct, our approach can be transferred directly to convolutional neural networks compression by enforcing structural sparsity that is able to achieve extremely sparse networks without accuracy deterioration.Mechanical Engineering | Vehicle Engineerin
Super pan-genome reveals extensive genomic variations associated with phenotypic divergence in Actinidia
No full textAbstract Kiwifruit is an economically and nutritionally important horticultural fruit crop worldwide. The genomic data of several kiwifruit species have been released, providing an unprecedented opportunity for pan-genome analysis to comprehensively investigate the inter- and intra-species genetic diversity and facilitate utilization for kiwifruit breeding. Here, we generated a kiwifruit super pan-genome using 15 high-quality assemblies of eight Actinidia species. For gene-based pan-genome, a total of 61,465 gene families were identified, and the softcore and dispensable genes were enriched in biological processes like response to endogenous stimulus, response to hormone and cell wall organization or biogenesis. Then, structural variations (SVs) against A. chinensis ‘Donghong’ were identified and then used to construct a graph-based genome. Further population-scale SVs based on resequencing data from 112 individuals of 20 species revealed extensive SVs which probably contributed to the phenotypic diversity among the Actinidia species. SV hotspot regions were found contributed to environmental adaptation. Furthermore, we systematically identified resistance gene analogs (RGAs) in the 15 assemblies and generated a pan-RGA dataset to reveal the diversity of genes potentially involved in disease resistance in Actinidia. The pan-genomic data obtained here is useful for evolutionary and functional genomic studies in Actinidia, and facilitates breeding design
Anemia in relation to body mass index and waist circumference among Chinese women
No full textExtent: 3 p.BACKGROUND: This study aimed to investigate the relationship of anemia and body mass index among adult women in Jiangsu Province, China. Data were collected in a sub-national cross-sectional survey, and 1,537 women aged 20 years and above were included in the analyses. Subjects were classified by body mass index (BMI) categories as underweight, normal weight, overweight and obese according to the Chinese standard. Central obesity was defined as a waist circumference ≥ 80 cm. Anemia was defined as hemoglobin concentration < 12 g/dl. Prevalence ratios (PRs) of the relationship between anemia and BMI or waist circumference were calculated using Poisson regression. FINDINGS: Overall, 31.1% of the Chinese women were anemic. The prevalence of overweight, obesity and central obesity was 34.2%, 5.8% and 36.2%, respectively. The obese group had the highest concentrations of haemoglobin compared with other BMI groups. After adjustment for confounders, overweight and obese women had a lower PR for anemia (PR: 0.72, 95% CI: 0.62-0.89; PR: 0.59, 95% CI: 0.43-0.79). Central obesity was inversely associated with anemia. CONCLUSION: In this Chinese population, women with overweight/obesity or central obesity were less likely to be anemic as compared to normal weight women. No measures are required currently to target anemia specifically for overweight and obese people in China.Yu Qin, Alida Melse-Boonstra, Xiaoqun Pan, Baojun Yuan, Yue Dai, Jinkou Zhao, Michael B. Zimmermann, Frans J. Kok, Minghao Zhou and Zumin Sh
A Dense Encoder–Decoder Network with Feedback Connections for Pan-Sharpening
No full textTo meet the need for multispectral images having high spatial resolution in practical applications, we propose a dense encoder–decoder network with feedback connections for pan-sharpening. Our network consists of four parts. The first part consists of two identical subnetworks, one each to extract features from PAN and MS images, respectively. The second part is an efficient feature-extraction block. We hope that the network can focus on features at different scales, so we propose innovative multiscale feature-extraction blocks that fully extract effective features from networks of various depths and widths by using three multiscale feature-extraction blocks and two long-jump connections. The third part is the feature fusion and recovery network. We are inspired by the work on U-Net network improvements to propose a brand new encoder network structure with dense connections that improves network performance through effective connections to encoders and decoders at different scales. The fourth part is a continuous feedback connection operation with overfeedback to refine shallow features, which enables the network to obtain better reconstruction capabilities earlier. To demonstrate the effectiveness of our method, we performed several experiments. Experiments on various satellite datasets show that the proposed method outperforms existing methods. Our results show significant improvements over those from other models in terms of the multiple-target index values used to measure the spectral quality and spatial details of the generated images
Determination of aerodynamic damping at high reduced frequencies
No full textForced response which is blade vibration due to an external excitation can lead to blade failure. The estimation of the level of vibration is dependent on the determination of aerodynamic damping. This thesisinvestigates the determination of aerodynamic damping at high reduced frequencies in turbomachines. The aerodynamic damping was calculated by a linearized Navier-Stokes flow solver with exact 3D non-reflecting boundary conditions. The method was validated using the two-dimensional test cases (Standard Configuration 5 and 8). Thereafter, two 3D profiles were also investigated: an aeroelastic turbine rig (AETR) which is a subsonic turbine case, and a virtual integrated compressor (VINK) which is a transonic compressor case. In AETR case, the first bending mode with reduced frequency 2.0 was studied. The 3D acoustic modes were calculated and the rate of decay was plotted as a function of nodal diameter and radial order. This plot identified six acoustic resonant points which included two points corresponding to the first radial order. The six resonance points correspond to six peaks in the damping curve. In VINK case, the fifth mode (1854 Hz, reduced frequency 3.1) was investigated. Acoustic resonance was predicted to occur for the first and second radial orders at the inlet. It was concluded that the higher order resonance points are influencing the damping curve. There were some inconsistencies in the results and grid convergence was not achieved. These inconsistencies were due to the difficulty in calculating the acoustic modes at the transonic inlet with an impinging shock.Aerodynamiskt påtvingade vibrationer, som är bladvibrationer på grund av en extern excitation kan leda till haveri. Prediktering av vibrationen är beroende av bestämning av aerodynamisk dämpning. I detta arbete undersöks bestämningen av aerodynamisk dämpning vid höga reducerade frekvenser i turbomaskiner. Den aerodynamiska dämpningen beräknades genom en linjäriserad Navier-Stokeslösare med exakta 3D icke-reflekterande gränsvillkor. Metoden validerades med hjälp av de tvådimensionella testfallen (Standardkonfiguration 5 och 8). Därefter undersöktes två 3D-profiler: en aeroelastisk turbinrigg (AETR), som är en subsonisk turbinenhet och en virtuell integrerad kompressor (VINK) som är ett transoniskt kompressorfall. I AETRfallet undersöktes det första böjningsformen med reducerad frekvens 2.0. 3D akustiska lägen beräknades och graden av förfall visades som en funktion av noddiameter och radiell grad. Denna metod identifierade sex akustiska resonanspunkter som innehöll två punkter som motsvarade den första radiella graden. De sex resonanspunkterna motsvarar sex toppar i dämpningskurvan. I VINK-fallet undersöktes den femte svängningsformen (1854 Hz, reducerad frekvens 3.1). Akustisk resonans förutspåddes inträffa för första och andra radiella graden vid inloppet. Slutsatsen drogs att de högre ordningens resonanspunkter påverkar dämpningskurvan. Det fanns vissa inkonsekvenser i resultaten och gridkonvergens uppnåddes inte. Dessa inkonsekvenser berodde på svårigheten att beräkna de akustiska svängningsformerna vid det transoniska inloppet med en stötvåg
Zinc biofortification of rice in China: a simulation of zinc intake with different dietary patterns
No full textA cross-sectional survey of 2819 adults aged 20 years and above was undertaken in 2002 in Jiangsu Province. Zinc intake was assessed using a consecutive 3-day 24-h dietary recall method. Insufficient and excess intake was determined according to the Chinese Dietary Recommended Intakes. Four distinct dietary patterns were identified namely “traditional”, “macho”, “sweet tooth”, and “healthy”. Intake of zinc from biofortified rice was simulated at an intermediate zinc concentration (2.7 mg/100 g) and a high zinc concentration (3.8 mg/100 g) in rice. Average total zinc intake was 12.0 ± 3.7 mg/day, and insufficiency of zinc intake was present in 15.4%. Simulated zinc intake from biofortified rice with intermediate and high zinc concentration decreased the prevalence of low zinc intake to 6.5% and 4.4%, respectively. The effect was most pronounced in the “traditional” pattern, with only 0.7% of insufficiency of zinc intake remaining in the highest quartile of the pattern. Zinc intake was inversely associated with the “sweet tooth” pattern. Zinc biofortifed rice improves dietary zinc intake and lowers risk for insufficient zinc intake, especially for subjects with a more “traditional” food pattern, but less for subjects with a “sweet tooth” food pattern.Yu Qin, Alida Melse-Boonstra, Baojun Yuan, Xiaoqun Pan, Yue Dai, Minghao Zhou, Rita Wegmueller, Jinkou Zhao, Frans J. Kok and Zumin Shihttp://arxiv.org/abs/arXiv:1205.001
Distribution and Drug Resistance of Pathogenic Bacteria and Prognosis in Patients with Septicemia Bloodstream Infection with Renal Insufficiency
No full textDeng Pan,1,* Pin Peng,2,* Yu Fang,3 Jun Lu,3 Minghao Fang3 1Department of Infectious Disease, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, Hubei, People’s Republic of China; 2Intensive Care Unit, Wuhan Asia General Hospital, Wuhan, Hubei, People’s Republic of China; 3Intensive Care Unit, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Minghao Fang, Intensive Care Unit, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, Hubei, 430030, People’s Republic of China, Tel +86-15071157405, Email [email protected]: The aim of this study was to investigate the distribution and drug resistance of pathogenic bacteria and the prognosis of patients with sepsis bloodstream infection with renal insufficiency.Methods: One hundred and twelve patients with septicemic bloodstream infection with renal insufficiency and 112 patients with septic bloodstream infection without renal insufficiency were selected as study group and control group, respectively. We compare the distribution of pathogenic bacteria, analyze the drug resistance of major bacteria, and compare the efficacy, the incidence of septic shock, duration of mechanical ventilation, hospitalization time, and duration of antimicrobial drug administration between the two groups.Results: A total of 140 pathogenic strains were isolated from blood cultures in the study group, and 136 strains were isolated from blood cultures in the control group. The sepsis bloodstream infection was mainly caused by Gram-negative bacteria, accounting for 59.42% (164/276). Among the gram-negative bacteria, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii had higher resistance rates to levofloxacin, ceftazidime, piperacillin sodium tazobactam, and amikacin. Among the gram-positive bacteria, Streptococcus pneumoniae, Enterococcus, and Staphylococcus aureus had high resistance rates to clindamycin, cefazolin, penicillin G, gentamicin, azithromycin, and levofloxacin. The rate of extended spectrum β-lactamase (ESBLs)-producing enterobacteria and multi-drug resistant Pseudomonas aeruginosa (MDR-PA) infection was significantly higher in the study group than in the control group; there was no difference in multi-drug resistant Acinetobacter baumannii (MDR-AB), vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA) between the two groups. The duration of hospitalization and the duration of antimicrobial drug administration were longer in the study group than in the control group.Conclusion: The pathogenic bacteria in patients with sepsis bloodstream infection with renal insufficiency are mainly Gram-negative bacteria, are more difficult to be cured, have a longer course of treatment, and need to use antibacterial drugs for a long time.Keywords: sepsis bloodstream infection with renal insufficiency, pathogenic bacteria, drug resistance, prognosi
Pan-Genome-Wide Association Study of Serotype 19A Pneumococci Identifies Disease-Associated Genes
No full textABSTRACT Despite the widespread implementation of pneumococcal vaccines, hypervirulent Streptococcus pneumoniae serotype 19A is endemic worldwide. It is still unclear whether specific genetic elements contribute to complex pathogenicity of serotype 19A isolates. We performed a large-scale pan-genome-wide association study (pan-GWAS) of 1,292 serotype 19A isolates sampled from patients with invasive disease and asymptomatic carriers. To address the underlying disease-associated genotypes, a comprehensive analysis using three methods (Scoary, a linear mixed model, and random forest) was performed to compare disease and carriage isolates to identify genes consistently associated with disease phenotype. By using three pan-GWAS methods, we found consensus on statistically significant associations between genotypes and disease phenotypes (disease or carriage), with a subset of 30 consistently significant disease-associated genes. The results of functional annotation revealed that these disease-associated genes had diverse predicted functions, including those that participated in mobile genetic elements, antibiotic resistance, virulence, and cellular metabolism. Our findings suggest the multifactorial pathogenicity nature of this hypervirulent serotype and provide important evidence for the design of novel protein-based vaccines to prevent and control pneumococcal disease. IMPORTANCE It is important to understand the genetic and pathogenic characteristics of S. pneumoniae serotype 19A, which may provide important information for the prevention and treatment of pneumococcal disease. This global large-sample pan-GWAS study has identified a subset of 30 consistently significant disease-associated genes that are involved in mobile genetic elements, antibiotic resistance, virulence, and cellular metabolism. These findings suggest the multifactorial pathogenicity nature of hypervirulent S. pneumoniae serotype 19A isolates and provide implications for the design of novel protein-based vaccines
Percolation at the uniqueness threshold via subgroup relativization
No full textWe study percolation on nonamenable groups at the uniqueness threshold , the critical value that separates the phase in which there are infinitely many infinite clusters from the phase in which there is a unique infinite cluster. The number of infinite clusters at itself is a subtle question, depending on the choice of group, with only a relatively small number of examples understood. In this paper, we do the following:
1. Prove non-uniqueness at in a new class of examples, namely those groups that contain an amenable, -normal subgroup of exponential growth. Concrete new examples to which this result applies include lamplighters over nonamenable base groups.
2. Prove a co-heredity property of a certain strong form of non-uniqueness at , stating that this property is inherited from a -normal subgroup to the entire group. Remarkably, this co-heredity property is the same as that proven for the vanishing of the first Betti number by Peterson and Thom (Invent. Math. 2011), supporting the conjecture that the two properties are equivalent.
Our proof is based on the method of subgroup relativization, and relies in particular on relativized versions of uniqueness monotonicity, the equivalence of non-uniqueness and connectivity decay, the sharpness of the phase transition, and the Burton-Keane theorem. As a further application of the relative Burton-Keane theorem, we resolve a question of Lyons and Schramm (Ann. Probab. 1999) concerning intersections of random walks with percolation clusters.30 page
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