1,721,461 research outputs found
Long-term effectiveness of laparoscopic presacral neurectomy for the treatment of severe chronic pelvic pain due to endometriosis
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Hypertension and cardiovascular and lipoprotein abnormalities in the Polycystic Ovary Syndrome
No full textPolycystic ovary syndrome (PCOS) should be considered not only a reproductive problem but a complex, endocrine, multifaceted disease with important health implications. Several lines of evidence suggest an increased cardiovascular risk and cardiovascular disease characterized by impairment of cardiac structure and function, endothelial dysfunction, lipid abnormalities, and chronic low-grade inflammation. All these features are probably linked to the insulin resistance often present in women with PCOS. Cardiovascular abnormalities represent important long-term sequelae of PCOS that warrant further critical investigation
Metformina. impieghi clinici e sperimentali
No full textQuesto volume racchiude le conoscenze più aggiornate sulla metformina, farmaco insulino-sensibilizzante ampiamente diffuso in campo diabetologico che, negli ultimi tempi, è stato sperimentato per indicazioni cliniche nel campo della terapia della sindrome dell’ovaio policistico (PCOS).
Da qui l’esigenza di diffondere e stilare un testo completo e aggiornato, che potesse essere consultato non solo da ultra-specialisti in materia, ma anche da diabetologi, endocrinologi, ginecologi, medici internisti, medici di medicina generale e specializzandi che abbiano la voglia e l’esigenza di aggiornarsi sulle conoscenze ormai consolidate e su quelle di recente acquisizione circa l’impiego diffuso della metformina nella pratica clinica.
L’approccio all’argomento e il taglio dato al testo seguono una metodologia rigorosamente scientifica, senza tralasciare di illustrare l’applicazione nella pratica clinica quotidiana dei risultati delle ricerche.
Nella prima parte gli autori hanno illustrato le caratteristiche generali del farmaco con la descrizione del meccanismo d’azione e del razionale del suo impiego nella terapia del diabete e della PCOS.
Segue l’illustrazione di farmacocinetica, effetti collaterali farmaco-correlati, regimi terapeutici nei diversi impieghi clinici e potenziali fattori predittivi di risposta.
Nella seconda parte sono stati analizzati i risultati dell’impiego per la sua indicazione classica, quale consolidata terapia per pazienti affetti da diabete mellito di tipo 2.
In secondo luogo, sono stati descritti i risultati degli studi clinici e sperimentali che hanno analizzato l’impiego innovativo della metformina in pazienti affette o ad alto rischio per PCOS
Could the Mediterranean diet be effective in women with polycystic ovary syndrome? A proof of concept.
No full textNo abstract availabl
Presurgical assessment of intra abdominal visceral fat in obese patients
No full textTo date, obesity is simply defined as body mass index (BMI) higher or equal to 30 kg/m2 (National Heart, Lung, and Blood Institute/National Institutes of Diabetes and Digestive and Kidney diseases 1998). Although BMI is widely accepted as a marker of adiposity in population-based studies, and is recognized as an instrument to diagnose obesity for all age groups, it should be more properly seen as an index of weight excess, rather than body fatness
Safety of laparoscopy vs laparotomy in the surgical staging of endometrial cancer. a systematic review and metaanalysis of randomized controlled trials
No full textThe aim of the current study was to compare the safety of the laparoscopic vs abdominal approach to staging endometrial cancer. A search was conducted for randomized controlled trials that reported data from women with histologically confirmed endometrial cancer who underwent laparoscopic or abdominal surgery. An additional metaanalysis was performed. The primary endpoints were the rates of intraoperative and postoperative complications. A total of 8 original randomized controlled trials were included in the final analysis. No significant difference was observed in the relative risk (RR) for intraoperative complications between laparoscopy and laparotomy (RR, 1.25; 95% confidence interval, 0.99-1.56; P = .062). In contrast, a significant advantage of laparoscopy over laparotomy was obtained in terms of postoperative complications (RR, 0.71; 95% confidence interval, 0.63-0.79; P = .016). In comparison with abdominal surgery, the safety of the laparoscopic approach for surgical staging of endometrial cancer is similar in terms of intraoperative complications but results in fewer postoperative complications
Presurgical visceral fat assessment in obese patients with early stage endometrial cancer treated with laparoscopic approach: relationships with early laparotomic conversions
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