117,499 research outputs found
Among the Deep Sea Fishers, volume 16, issue 4 (January 1919)
No full textAn iceberg [illustration] -- "Report - report - report" / Wilfred T. Grenfell, M.D. -- Dr. Harry L. Paddon / By One Who Knows Him, William J. Barnes, M.D., Harold C. Stuart, M.D., Frank L. Babbott, Jr., M.D. -- North West River / Mina G. Paddon -- A winter afternoon in Labrador / Harry L. Paddon, M.D. -- Dr. Grenfell's morning lesson / Rev. Theodore A. Greene -- A New Year [poem] -- War orphans of Italy -- Log of the S.S. Strathcona (concluded from October magazine) / Wilfred T. Grenfell, M.D. -- Map of Newfoundland and Labrador -- Spotted Islands - summer, 1918 / Francis Brewer -- Report of St. Anthony library work, 1917 -- The world wide influence of Grenfell / Jerome Davis -- Dr. Clarence John Blake -- Theodore Roosevelt -- Mrs. George B. Cluett -- Major Harrison Briggs Webster, M.R.C. -- Association items -- Notes and comments -- "A job that's worth while."Includes map: Labrador and Newfoundland (p. [169]), showing Grenfell Missions, Moravian Missions, and co-operative stores.Among the Deep Sea Fishers: the Official Organ of the International Grenfell Association. This journal was published quarterly from 1903 to 1981 with the twofold purpose of providing "a record of Mission activities [and] also a strong and convincing appeal to every supporter and friend of Dr. Grenfell's work." The articles describe mission life, services and experiences. The Mission began under the auspices of the Royal National Mission to Deep Sea Fishermen but later a separate mission, the International Grenfell Association, was formed by Dr. Wilfred Grenfell
Among the Deep Sea Fishers, volume 27, issue 4 (January 1930)
No full textFishing through the ice, St. Anthony [illustration] -- “A happy new year to all” / Sir Wilfred Grenfell -- Some suggestions on the tuberculosis problem / Donald McI. Johnson, M.D. -- “Ye goode olde dayes” (concluded) / Harry L. Paddon, M.D. -- Retrospect of a year at Mutton Bay / Bessie J. Banfill -- Second Annual Report of the Occupational Therapy Department / Julia L. Crawford -- The new rector of St. Andrews -- The St. Anthony Orphanage / Anne W. Conrow -- Travel along the Canadian Labrador / Irene I. Biss -- Dr. Paddon reviews last summer's work -- Crossing the bar / Harry L. Paddon, M.D. -- From the doctor's mail bag -- Dr. Moret’s twine fund -- New term at Yale School / Elizabeth Criswell -- Shotguns needed for partridges / A.A.W. -- Tragedy at Quirpon / W.T.G. -- Sir Wilfred’s 1930 lecture tour -- The “Strathcona” needs help -- Association items -- Brief items.Among the Deep Sea Fishers: the Official Organ of the International Grenfell Association. This journal was published quarterly from 1903 to 1981 with the twofold purpose of providing "a record of Mission activities [and] also a strong and convincing appeal to every supporter and friend of Dr. Grenfell's work." The articles describe mission life, services and experiences. The Mission began under the auspices of the Royal National Mission to Deep Sea Fishermen but later a separate mission, the International Grenfell Association, was formed by Dr. Wilfred Grenfell
Among the Deep Sea Fishers, volume 17, issue 3 (October 1919)
No full textA cruise on the Strathcona / Fullerton L. Waldo -- The log of a vagabond / Wilfred T. Grenfell, M.D. -- The mission stations -- The Y.W.C.A. on the Labrador / A.E.G. -- The children's page -- The orphaned children of Labrador and their prospects / Harry L. Paddon, M.D. -- Association items -- A Labrador Doctor - the autobiography of Dr. Grenfell -- Notes and comments.Among the Deep Sea Fishers: the Official Organ of the International Grenfell Association. This journal was published quarterly from 1903 to 1981 with the twofold purpose of providing "a record of Mission activities [and] also a strong and convincing appeal to every supporter and friend of Dr. Grenfell's work." The articles describe mission life, services and experiences. The Mission began under the auspices of the Royal National Mission to Deep Sea Fishermen but later a separate mission, the International Grenfell Association, was formed by Dr. Wilfred Grenfell
Among the Deep Sea Fishers, volume 69, issue 2 (July 1971)
No full textWhy Sir Wilfred Grenfell? / Dr. Theodore L. Badger -- Emily Fowler : Grenfell's jack-of-all-trades / William Savage -- The Reverend Henry Gordon / W. Anthony Paddon, M.D. -- Betty Seabrook retires -- Whaling : new direction for an old industry -- On and off the coast -- Grenfell staff needs -- Association news -- Supporting and branch associations.Among the Deep Sea Fishers: the Official Organ of the International Grenfell Association. This journal was published quarterly from 1903 to 1981 with the twofold purpose of providing "a record of Mission activities [and] also a strong and convincing appeal to every supporter and friend of Dr. Grenfell's work." The articles describe mission life, services and experiences. The Mission began under the auspices of the Royal National Mission to Deep Sea Fishermen but later a separate mission, the International Grenfell Association, was formed by Dr. Wilfred Grenfell
Analysis of the localization of STE6/CFTR chimeras in a Saccharomyces cerevisiae model for the cystic fibrosis defect CFTRΔF508
No full textThe use of yeast as a model system to study mammalian proteins is attractive, because yeast genetic tools can be utilized if a suitable phenotype is created, STE6, the Saccharomyces cerevisiae a-factor mating pheromone transporter, and CFTR, the mammalian cystic fibrosis transmembrane conductance regulator, are both members of the ATP binding cassette (ABC) superfamily. Teem et al, (1993) described a yeast model for studying a mutant form of the cystic fibrosis protein, CFTRΔF508. The model involved expression of a chimeric molecule in which a portion of yeast STE6 was replaced with the corresponding region from mammalian CFTR. The STE6/CFTR chimera complemented a ste6 mutant strain for mating, indicating that it could export a-factor. However, mating efficiency was dramatically reduced upon introduction of ΔF508, providing a yeast phenotype for this mutation. In human cells, the ΔF508 mutation results in retention of CFTR in the endoplasmic reticulum (ER), and possibly in reduction of its chloride-channel activity. Here we examine the basis for the differences in STE6 activity promoted by the wild-type and mutant STE6/CFTR chimeras, By analysis of protein stability and subcellular localization, we find that the mutant chimera is not ER-retained in yeast. We conclude that the molecular basis for the reduced mating of the STE6/CFTRΔF508 chimera must reflect a reduction in its capacity to transport a-factor, rather than mistrafficking. Thus, STE6/CFTRΔF508 in yeast appears to be a good genetic model to probe certain aspects of protein function, but not to study protein localization
Among the Deep Sea Fishers, volume 26, issue 2 (July 1928)
No full textThe new Maraval, bound for North West River [illustration] -- New developments in many fields / Sir Wilfred Grenfell -- A new barometer for the Strathcona -- Two loving tributes to Dr. Joseph A. Andrews / Wilfred T. Grenfell, Charles S. Curtis, M.D. -- The landing of the Bremen / Greta Mae Ferris -- Honors for Sir Wilfred -- The mission as a practical religion / Sir Wilfred Grenfell -- The winter at Forteau -- News from North West River / Harry L. Paddon, M.D. -- An Easter letter from Labrador / Harry L. Paddon, M.D. -- Concerning Miss Olive Lesley / W.T.G. -- Permanent staff and volunteer workers -- Save your old silk stockings / W.T.G. -- Men who do things / Sir Wilfred Grenfell -- Random thoughts of a mission volunteer / Carl W. Eberbach, M.D. -- The summer's health program at Poverty Cove / Marita D. Lyon -- The saga of Twillie, the Ford / Charles E. Parsons, M.D. -- Radio schedules for dwellers in Arctic and Sub-Arctic regions -- Children's page -- The wreck of the Stella Maris / W.T.G. -- A sheep dog for the mission -- Association items -- Thanks from Miss Ferris -- Governor Allardyce retires -- The I.G.A. spring fair, North West River / Harry L. Paddon, M.D. -- A talking movie of the mission -- The Alumni Annual Dinner -- Clothing and other supplies needed -- A cup of milk / W.T.G. -- The last voyage of the Thistle / Harry L. Paddon, M.D. -- Gordon Cove School - Building Fund.Among the Deep Sea Fishers: the Official Organ of the International Grenfell Association. This journal was published quarterly from 1903 to 1981 with the twofold purpose of providing "a record of Mission activities [and] also a strong and convincing appeal to every supporter and friend of Dr. Grenfell's work." The articles describe mission life, services and experiences. The Mission began under the auspices of the Royal National Mission to Deep Sea Fishermen but later a separate mission, the International Grenfell Association, was formed by Dr. Wilfred Grenfell
Among the Deep Sea Fishers, volume 27, issue 3 (October 1929)
No full textA Labrador sunset [illustration] -- Food problems on the Labrador / Helen S. Mitchell, Ph.D. -- The Cartwright venture / Hanson W. Baldwin -- "Vale, Indian Harbor" / Harry L. Paddon, M.D. -- The new "George B. Cluett" / Wilfred T. Grenfell -- Sir Wilfred's log -- The industrial department and the people / Edith Tallant -- The haul-up slip and marine railway / Wilfred T. Grenfell -- Aftercare of sufferers from tuberculosis / Wilfred T. Grenfell and Harry L. Paddon, M.D. -- Today and yesterday at Flower's Cove / J.T. Richards -- Silk stockings needed in unlimited quantity -- The coming of the new "Maraval" / Harry L. Paddon, M.D. -- Notes on various topics / Sir Wilfred Grenfell -- Association items -- News from the Stations -- Brief items.Among the Deep Sea Fishers: the Official Organ of the International Grenfell Association. This journal was published quarterly from 1903 to 1981 with the twofold purpose of providing "a record of Mission activities [and] also a strong and convincing appeal to every supporter and friend of Dr. Grenfell's work." The articles describe mission life, services and experiences. The Mission began under the auspices of the Royal National Mission to Deep Sea Fishermen but later a separate mission, the International Grenfell Association, was formed by Dr. Wilfred Grenfell
Among the Deep Sea Fishers, volume 72, issue 1 (January 1975)
No full textMedicine in northern Labrador - the first years / W.A. Paddon, M.D. -- Labrador profile: the Montagnais / Theodore L. Badger, M.D. -- Book review -- On and off the coast -- Association news -- Supporting and branch associations.Includes map: [Newfoundland and Labrador] (inside back cover).Among the Deep Sea Fishers: the Official Organ of the International Grenfell Association. This journal was published quarterly from 1903 to 1981 with the twofold purpose of providing "a record of Mission activities [and] also a strong and convincing appeal to every supporter and friend of Dr. Grenfell's work." The articles describe mission life, services and experiences. The Mission began under the auspices of the Royal National Mission to Deep Sea Fishermen but later a separate mission, the International Grenfell Association, was formed by Dr. Wilfred Grenfell
Among the Deep Sea Fishers, volume 73, issue 2 (April 1976)
No full textThe old order changeth giving place to new / Theodore L. Badger, M.D. -- Summer with the Eskimos on the north Labrador coast / R. Ann Brister -- Jack Watts of North West River / W.A. Paddon, M.D. -- Book review -- The church in medical work - past, present and future / D. Black, M.D. -- On and off the coast -- Supporting and branch associations.Includes map: [Newfoundland and Labrador] (inside back cover).Among the Deep Sea Fishers: the Official Organ of the International Grenfell Association. This journal was published quarterly from 1903 to 1981 with the twofold purpose of providing "a record of Mission activities [and] also a strong and convincing appeal to every supporter and friend of Dr. Grenfell's work." The articles describe mission life, services and experiences. The Mission began under the auspices of the Royal National Mission to Deep Sea Fishermen but later a separate mission, the International Grenfell Association, was formed by Dr. Wilfred Grenfell
Among the Deep Sea Fishers, Volume 33, Issue 1 (April 1935)
No full textWard in the St. Anthony hospital [illustration] -- Activities at St. Anthony in 1934 / Charles S. Curtis, M.D. -- An Easter message / Sir Wilfred Grenfell -- Making a map of Northern Labrador / O.M. Miller -- Dr. Paddon's winter itinerary / Harry L. Paddon, M.D. -- Letters / Harry L. Paddon, K.M. Keddie, Wilfred T. Grenfell -- Needlework Guild column / Edith Sloan Griscom -- Industrial Department notices -- Extracts from "North Wind" -- Alumni news -- Association items / Shirley S. Smith, Betty Maclay, K. Spalding -- Brief items -- Map [Grenfell stations]Among the Deep Sea Fishers: the Official Organ of the International Grenfell Association. This journal was published quarterly from 1903 to 1981 with the twofold purpose of providing "a record of Mission activities [and] also a strong and convincing appeal to every supporter and friend of Dr. Grenfell's work." The articles describe mission life, services and experiences. The Mission began under the auspices of the Royal National Mission to Deep Sea Fishermen but later a separate mission, the International Grenfell Association, was formed by Dr. Wilfred Grenfell
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